Chalcones: Beyond Bioactive Properties – Exploring Their Potential as Polymeric Materials

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Year : 2024 | Volume : | : | Page : –
By
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Vishal Raj,

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Abhishek Chandola,

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Ujjwal Nautiyal,

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Amit Semwal,

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Rahul Pandey,

  1. Student, B. Pharm, Department of Pharmaceutics, College of Pharmacy, Shivalik Campus, Dehradun, Uttarakhand, India
  2. Assistant Professor, Department of Pharmaceutics, Himalayan School of Pharmaceutical Sciences, Swami Rama Himalayan University, Joly Grant, Dehradun, Uttarakhand, India
  3. Associate Professor, Department of Pharmaceutics, Himalayan School of Pharmaceutical Sciences, Swami Rama Himalayan University, Joly Grant, Dehradun, Uttarakhand,
  4. Professor, Department of Pharmaceutics, College of Pharmacy, Shivalik Campus, Dehradun, Uttarakhand, India
  5. Assistant Professor, Department of Pharmaceutics, Himalayan School of Pharmaceutical Sciences, Swami Rama Himalayan University, Joly Grant, Dehradun, Uttarakhand, India

Abstract document.addEventListener(‘DOMContentLoaded’,function(){frmFrontForm.scrollToID(‘frm_container_abs_122880’);});Edit Abstract & Keyword

Chalcones, a class of natural compounds characterized by their unique chemical structure, have garnered significant attention in recent years for their diverse pharmacological and biological activities. This review aims to comprehensively assess and summarize the latest research spanning the last five years. By synthesizing findings from a plethora of studies, this retrospective analysis elucidates the evolving landscape of chalcone research, shedding light on their therapeutic potential and biological effects. The primary objective of this review is to identify and analyse the gaps in current knowledge regarding the toxicological, pharmacological and biological activities of chalcones. By critically evaluating the existing literature, we aim to pinpoint areas where further investigation is needed, thereby guiding future research endeavours. Central topics addressed in this review encompass the wide-ranging chemical benefits and biological activities exhibited by chalcones, including their anti-inflammatory, antioxidant, anticancer, and biochemical repairing attributes. By identifying gaps in our understanding and emphasizing potential avenues for exploration, this retrospective analysis aims to inspire and guide researchers in harnessing the full pharmacological and polymeric potential of chalcones in the years to come.

Keywords: Chalcones, anti-inflammatory, pharmacological, Biochemical, Synthetic compounds, Polymer.

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How to cite this article:
Vishal Raj, Abhishek Chandola, Ujjwal Nautiyal, Amit Semwal, Rahul Pandey. Chalcones: Beyond Bioactive Properties – Exploring Their Potential as Polymeric Materials. Journal of Polymer and Composites. 2024; ():-.
How to cite this URL:
Vishal Raj, Abhishek Chandola, Ujjwal Nautiyal, Amit Semwal, Rahul Pandey. Chalcones: Beyond Bioactive Properties – Exploring Their Potential as Polymeric Materials. Journal of Polymer and Composites. 2024; ():-. Available from: https://journals.stmjournals.com/jopc/article=2024/view=0


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References
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  • Raut NA, Dhore PW, Saoji SD, Kokare DM. Selected bioactive natural products for diabetes mellitus. Studies in Natural Products Chemistry. 2016 Jan 1;48:287-322.
  • Zhuang C, Zhang W, Sheng C, Zhang W, Xing C, Miao Z. Chalcone: a privileged structure in medicinal chemistry. Chemical reviews. 2017 Jun 28;117(12):7762-810.
  • Ouyang Y, Li J, Chen X, Fu X, Sun S, Wu Q. Chalcone Derivatives: Role in Anticancer Therapy. Biomolecules 2021, 11, 894.
  • Kontogiorgis C, Mantzanidou M, Hadjipavlou-Litina D. Chalcones and their potential role in inflammation. Mini reviews in medicinal chemistry. 2008 Oct 1;8(12):1224-42.
  • Kudličková Z, Michalková R, Salayová A, Ksiažek M, Vilková M, Bekešová S, Mojžiš J. Design, synthesis, and evaluation of novel indole hybrid chalcones and their antiproliferative and antioxidant activity. Molecules. 2023 Sep 12;28(18):6583.
  • Birsa ML, Sarbu LG. Hydroxy chalcones and analogs with chemopreventive properties. International Journal of Molecular Sciences. 2023 Jun 26;24(13):10667.
  • Constantinescu T, Lungu CN. Anticancer activity of natural and synthetic chalcones. International journal of molecular sciences. 2021 Oct 20;22(21):11306.
  • Ouyang W, Chen J, Shi Z, Fang X. Self-powered UV photodetectors based on ZnO nanomaterials. Applied physics reviews. 2021 Sep 1;8(3).
  • Nematollahi MH, Mehrabani M, Hozhabri Y, Mirtajaddini M, Iravani S. Antiviral and antimicrobial applications of chalcones and their derivatives: From nature to greener synthesis. Heliyon. 2023 Oct 1;9(10).
  • Pereira R, Silva AM, Ribeiro D, Silva VL, Fernandes E. Bis-chalcones: A review of synthetic methodologies and anti-inflammatory effects. European Journal of Medicinal Chemistry. 2023 Apr 5;252:115280.
  • Mittal R, Sharma S, Kushwah AS, Yaqoob O, Kumari D. A Comprehensive Review on the Anti-inflammatory Activity of Chalconesderived Moieties. Current Traditional Medicine. 2024 Feb 1;10(1):131-43.
  • Wang S, Li C, Zhang L, Sun B, Cui Y, Sang F. Isolation and biological activity of natural chalcones based on antibacterial mechanism classification. Bioorganic & Medicinal Chemistry. 2023 Aug 23:117454.
  • Pereira R, Silva AM, Ribeiro D, Silva VL, Fernandes E. Bis-chalcones: A review of synthetic methodologies and anti-inflammatory effects. European Journal of Medicinal Chemistry. 2023 Apr 5;252:115280.
  • Michalkova R, Mirossay L, Kello M, Mojzisova G, Baloghova J, Podracka A, Mojzis J. Anticancer potential of natural chalcones: in vitro and in vivo evidence. International Journal of Molecular Sciences. 2023 Jun 19;24(12):10354.
  • Olender D, Sowa-Kasprzak K, Pawełczyk A, Skóra B, Zaprutko L, Szychowski KA. Curcuminoid Chalcones: Synthesis and Biological Activity against the Human Colon Carcinoma (Caco-2) Cell Line. Current Medicinal Chemistry. 2024.
  • Sharma P, Singh M, Singh V, Singh TG, Singh T, Ahmad SF. Recent Development of Novel Aminoethyl-Substituted Chalcones as Potential Drug Candidates for the Treatment of Alzheimer’s Disease. Molecules. 2023 Sep 12;28(18):6579.
  • Sabarathinam S, Ganamurali N. Chalcones reloaded: an integration of network pharmacology and molecular docking for type 2 diabetes therapy. Journal of Biomolecular Structure and Dynamics. 2023 Aug 24:1-3.
  • Kumar S, Oh JM, Abdelgawad MA, Abourehab MA, Tengli AK, Singh AK, Ahmad I, Patel H, Mathew B, Kim H. Development of isopropyl-tailed chalcones as a new class of selective MAO-B inhibitors for the treatment of Parkinson’s disorder. ACS omega. 2023 Feb 7;8(7):6908-17.
  • Birsa ML, Sarbu LG. Hydroxy chalcones and analogs with chemopreventive properties. International Journal of Molecular Sciences. 2023 Jun 26;24(13):10667.
  • Pojtanadithee P, Hengphasatporn K, Suroengrit A, Boonyasuppayakorn S, Wilasluck P, Deetanya P, Wangkanont K, Sukanadi IP, Chavasiri W, Wolschann P, Langer T. Identification of Promising Sulfonamide Chalcones as Inhibitors of SARS-CoV-2 3CLpro Through Structure-Based Virtual Screening and Experimental Approaches. Journal of Chemical Information and Modeling. 2023 Aug 15;63(16):5244-58.
  • Nematollahi MH, Mehrabani M, Hozhabri Y, Mirtajaddini M, Iravani S. Antiviral and antimicrobial applications of chalcones and their derivatives: From nature to greener synthesis. Heliyon. 2023 Oct 1;9(10).
  • Mallia A, Sloop J. Advances in the Synthesis of Heteroaromatic Hybrid Chalcones. Molecules. 2023 Apr 4;28(7):3201.
Ahead of Print Open Access Review Article
Volume
Received 20/04/2024
Accepted 08/08/2024
Published 03/12/2024
198