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Shalini Mani,
- Research sholor, Centre for Emerging Diseases, Department of Biotechnology, Jaypee Institute of Information Technology, Noida, Uttar pradesh, India
Abstract document.addEventListener(‘DOMContentLoaded’,function(){frmFrontForm.scrollToID(‘frm_container_abs_122093’);});Edit Abstract & Keyword
Metformin is widely used to manage Type 2 Diabetes, but its effectiveness is limited by low intestinal absorption, high dose requirements, and a short half-life. To tackle these challenges, several nano-drug delivery systems have been designed to optimize the delivery of metformin and enhance its therapeutic efficacy. Nanoparticles (NPs) have emerged as key players in medicine, biology, and pharmacology, gaini considerable attention for their potential applications. Polymeric NPs are among the most commonly utilized nanomaterials in nanomedicine due to their diverse applications. Chitosan (CS)-based polymeric NPs offer several key benefits, includingm biodegradability, biocompatibility, non-toxicity, bioactivity, ease of synthesis, and targeted delivery, making them highly suitable as drug carriers. CS NPs formed through ionic gelation are amongst the most studied nanosystems for drug delivery. Chitosan is also widely recognized as an effective nmucoadhesive polymer, capable of enhancing the bioavailability of drugs and improving cellular permeability. In this study, metformin-loaded chitosan TPP nanoparticles, stabilized by PF-127, were formulated, and characterized. We have incorporated the Ionic Gelation method for the formulation of nanoparticles. Physiochemical analyses such as FTIR and DLS were conducted. From the FTIR results, the successful synthesis of nanoparticles was confirmed. Also, the formulated nanoparticles showed mean hydrodynamic size of 188.8 nm, a zeta potential of -18.3 mV, and a drug entrapment efficiency of up to 41%.
Keywords: Polymeric, Metformin, Ionic Gelation Method, Chitosan
Shalini Mani. Synthesis and Characterization of PF-127 Stabilized Metformin Encapsulated Chitosan-TPP Nanoparticles. Nano Trends – A Journal of Nano Technology & Its Applications. 2024; ():-.
Shalini Mani. Synthesis and Characterization of PF-127 Stabilized Metformin Encapsulated Chitosan-TPP Nanoparticles. Nano Trends – A Journal of Nano Technology & Its Applications. 2024; ():-. Available from: https://journals.stmjournals.com/nts/article=2024/view=0
References
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1. Lin X, Xu Y, Pan X, Xu J, Ding Y, Sun X, Song X, Ren Y, Shan PF. Global, regional, and national burden and trend of diabetes in 195 countries and territories: an analysis from 1990 to 2025. Scientific reports. 2020 Sep 8;10(1):1-1. https://doi.org/10.1038/s41598-020-71908-9 2. Arafa K, Shamma RN, El-Gazayerly ON, El-Sherbiny IM. Facile development, characterization, and optimization of new metformin-loaded nanocarrier system for efficient colon cancer adjunct therapy. Drug Development and Industrial Pharmacy. 2018 Jul 3;44(7):1158- 70.https://doi.org/10.1080/03639045.2018.14384634 3. Liang X, Giacomini KM. Transporters involved in metformin pharmacokinetics and treatment response. Journal of pharmaceutical sciences. 2017 Sep 1;106(9):2245-50..https://doi.org/10.1016/j.xphs.2017.04.078 4. Chen Y, Shan X, Luo C, He Z. Emerging nanoparticulate drug delivery systems of metformin. Journal of Pharmaceutical Investigation. 2020 May;50:219 30..https://doi.org/10.1007/s40005-020-00480-1 5. Zahin N, Anwar R, Tewari D, Kabir MT, Sajid A, Mathew B, Uddin MS, Aleya L, Abdel-Daim MM. Nanoparticles and its biomedical applications in health and diseases: special focus on drug delivery. Environmental Science and Pollution Research. 2020 Jun;27(16):19151-68.https://doi.org/10.1007/s11356- 019-05211-0 6. Miladi K, Sfar S, Fessi H, Elaissari A. Nanoprecipitation process: from particle preparation to in vivo applications. Polymer Nanoparticles for Nanomedicines: A Guide for their Design, Preparation and Development. 2016:17-53.https://doi.org/10.1007/978-3-319-41421-8_2 7. Ekladious I, Colson YL, Grinstaff MW. Polymer–drug conjugate therapeutics: advances, insights and prospects. Nature reviews Drug discovery. 2019 Apr;18(4):273-94.https://doi.org/10.1038/s41573-018-0005-0 8. Schmitt V, Kesch C, Jackson JK, Bidnur S, Beraldi E, Yago V, Bowden M, Gleave ME. Design and characterization of injectable poly (lactic-co-glycolic acid) pastes for sustained and local drug release. Pharmaceutical research. 2020 Mar;37:1-3. https://doi.org/10.1007/s11095-019-2730-4 9. Sangnim T, Dheer D, Jangra N, Huanbutta K, Puri V, Sharma A. Chitosan in oral drug delivery formulations: A review. Pharmaceutics. 2023 Sep 21;15(9):2361.https://doi.org/10.3390/pharmaceutics15092361 10. Jafernik K, Ładniak A, Blicharska E, Czarnek K, Ekiert H, Wiącek AE, Szopa A. Chitosan-based nanoparticles as effective drug delivery systems—a review. Molecules. 2023 Feb 18;28(4):1963.https: //doi.org/10.3390/molecules28041963 11. Jiménez-Gómez CP, Cecilia JA. Chitosan: a natural biopolymer with a wide and varied range of applications. Molecules. 2020 Sep 1;25(17):3981. https://doi.org/10.3390/molecules25173981 12. Hisham F, Akmal MM, Ahmad F, Ahmad K, Samat N. Biopolymer chitosan: Potential sources, extraction methods, and emerging applications. Ain Shams Engineering Journal. 2024 Feb 1;15(2):102424.https://doi.org/10.1016/j.asej.2023.102424 13. Khan I, Saeed K, Khan I. Nanoparticles: Properties, applications, and toxicities. Arab J Chem. 2019;12(7):908-31. https://doi.org/10.1016/j.arabjc.2017.05.011 14. Joudeh N, Linke D. Nanoparticle classification, physicochemical properties, characterization, and applications: a comprehensive review for biologists. J Nanobiotechnology. 2022;20(1):262. https://doi.org/10.1186/s12951-022-01477-8 15. Hoang NH, Le Thanh T, Sangpueak R, Treekoon J, Saengchan C, Thepbandit W, Papathoti NK, Kamkaew A, Buensanteai N. Chitosan nanoparticles-based ionic gelation method: a promising candidate for plant disease management. Polymers. 2022 Feb 9;14(4):662.https://doi.org/10.3390/polym14040662 16. El-Naggar NE, Shiha AM, Mahrous H, Mohammed AA. Green synthesis of chitosan nanoparticles, optimization, characterization and antibacterial efficacy against multi drug resistant biofilm-forming Acinetobacter baumannii. Scientific Reports. 2022 Nov 18;12(1):19869.https://doi.org/10.1038/s41598-022- 24303-5 17. Tiernan H, Byrne B, Kazarian SG. ATR-FTIR spectroscopy and spectroscopic imaging for the analysis of biopharmaceuticals. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2020 Nov 5;241:118636.https://doi.org/10.1016/j.sampre.2024.100122 18. Alvarez-Ordóñez A, Halisch J, Prieto M. Changes in Fourier transform infrared spectra of Salmonella enterica serovars Typhimurium and Enteritidis after adaptation to stressful growth conditions. International journal of food microbiology. 2010 Aug 15;142(1-2):97- 105.https://doi.org/10.1016/j.ijfoodmicro.2010.06.008
Nano Trends – A Journal of Nano Technology & Its Applications
| Volume | |
| Received | 15/10/2024 |
| Accepted | 26/11/2024 |
| Published | 28/11/2024 |