UNRAVELLING THE ENVIRONMENT, AROMA AND MOLECULAR EFFECTS ON MOOD FLUCTUATIONS: A REVIEW

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Year : 2024 | Volume : | : | Page : –
By
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Sharique Ahmad,

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Pushpendra D. Pratap,

  1. Professor, Department of Pathology, Era’s Lucknow Medical College and Hospital, Era University,, Lucknow Uttar Pradesh, India
  2. Research Analyst, Department of Biochemistry, Era’s Lucknow Medical College and Hospital, Era University, Lucknow Uttar Pradesh, India

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The ebb and flow of human emotions encompass a complex interplay of molecular processes governing mood fluctuations. This comprehensive review navigates the intricate realm of neurotransmitters, neuroplasticity, hormonal influences, genetics, and inflammation to unravel the molecular tapestry that shapes our emotional states. Foundational to mood regulation are neurotransmitters—serotonin, dopamine, and norepinephrine—orchestrating delicate balances within neural circuits. Recent molecular neuroscience elucidates their receptor pathways and signaling cascades, offering insights into how genetic predispositions and environmental factors impact mood disorders. This review dissects synaptic signaling mechanisms and neurotransmitter modulation, illuminating the intricate molecular basis of mood. Neuroplasticity, the brain’s adaptive prowess, emerges as a pivotal player in mood regulation. Molecular intricacies underlying synaptic plasticity and neural adaptation reveal the shaping of emotional landscapes over time. This exploration underscores the dynamic molecular foundation of resilience and vulnerability to mood fluctuations. The hormonal symphony orchestrated by the endocrine system, especially the hypothalamic-pituitary- adrenal (HPA) axis, significantly influences mood. Molecular insights into the crosstalk between hormonal and neurotransmitter systems unveil genomic and epigenetic mechanisms modulating mood-related brain circuits. Chronic stress-induced HPA axis dysregulation stands as a molecular contributor to mood disorders, spotlighting potential therapeutic avenues. Genetic landscapes intricately woven into mood disorders reflect a tapestry of multiple genes with varying impacts. Molecular genetics, encompassing genome-wide studies and epigenetic investigations, decode the complex interplay between genetic variations, gene expressions, and mood regulation. This understanding holds promise for personalized interventions. Inflammation emerges as a novel molecular player influencing mood regulation through immune-neural interactions. Molecular pathways linking immune activation to neurotransmitter alterations offer new perspectives on mood disorder aetiology, opening avenues for therapeutic interventions.

Keywords: Neurotransmitters, Environmental, Genetics, Molecular. Mood Disorders, Inflammation and Mood Regulation, Chronic Stress.

How to cite this article:
Sharique Ahmad, Pushpendra D. Pratap. UNRAVELLING THE ENVIRONMENT, AROMA AND MOLECULAR EFFECTS ON MOOD FLUCTUATIONS: A REVIEW. Research & Reviews: A Journal of Neuroscience. 2024; ():-.
How to cite this URL:
Sharique Ahmad, Pushpendra D. Pratap. UNRAVELLING THE ENVIRONMENT, AROMA AND MOLECULAR EFFECTS ON MOOD FLUCTUATIONS: A REVIEW. Research & Reviews: A Journal of Neuroscience. 2024; ():-. Available from: https://journals.stmjournals.com/rrjons/article=2024/view=0

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Ahead of Print Subscription Review Article
Volume
Received 23/08/2024
Accepted 02/09/2024
Published 08/11/2024
120

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