Shad Ahmad,
Mohd. Danish,
- Student, Department: Warner College of Dairy Technology, Sam Higginbottom University of Agriculture, Technology and Sciences, Allahabad, Uttar Pradesh, India
- Student, Department: Warner College of Dairy Technology, Sam Higginbottom University of Agriculture, Technology and Sciences, Allahabad, Uttar Pradesh, India
Abstract document.addEventListener(‘DOMContentLoaded’,function(){frmFrontForm.scrollToID(‘frm_container_abs_110445’);});Edit Abstract & Keyword
MicroRNAs (miRNAs) are small, non-coding RNA molecules that play a crucial role in post-transcriptional regulation of gene expression. In recent years, their significance has extended beyond cellular development and disease regulation, as emerging evidence suggests they are critical mediators in complex behavioral processes, including learning, memory, and decision-making. This article explores the role of miRNAs in regulating neural plasticity and cognitive functions in mammals, emphasizing their involvement in memory formation and cognitive decision-making. The biogenesis of miRNAs and their mechanisms of action specifically, the regulation of synaptic plasticity and long-term potentiation (LTP) are key to understanding their impact on behavioral outcomes. Several miRNAs, such as miR-132, miR-134, and miR-124, have been identified as essential modulators of memory processes, influencing synaptic strength and neural circuit reorganization. Through the regulation of key molecular pathways, including brain-derived neurotrophic factor (BDNF) and cAMP response element-binding protein (CREB), miRNAs shape the structural and functional plasticity necessary for memory storage and retrieval. miRNAs are implicated in cognitive flexibility and decision-making, particularly within the prefrontal cortex. This region, vital for executive functions, is regulated by miRNAs that influence risk assessment, reward processing, and choice behavior. The intricate feedback loops between miRNAs, transcription factors, and other molecular regulators highlight their broad influence on cognition and behavior. Given their central role in cognitive processes, miRNAs have also emerged as potential therapeutic targets for neurodegenerative diseases and cognitive disorders. Targeting specific miRNAs holds promise for restoring cognitive function in conditions such as Alzheimer’s and Parkinson’s diseases. However, challenges remain in the development of miRNA-based therapies, particularly in ensuring precise delivery and minimizing off-target effects. This review underscores the importance of miRNAs in behavioral regulation and calls for further research into their therapeutic potential in mammals.
Keywords: MicroRNAs, epigenetic regulation, Animal Behavior, Memory Formation.
Shad Ahmad, Mohd. Danish. MicroRNAs in Animal Behavior: Regulation of Memory and Decision-Making in Mammals. Research & Reviews : Journal of Veterinary Science and Technology. 2024; ():-.
Shad Ahmad, Mohd. Danish. MicroRNAs in Animal Behavior: Regulation of Memory and Decision-Making in Mammals. Research & Reviews : Journal of Veterinary Science and Technology. 2024; ():-. Available from: https://journals.stmjournals.com/rrjovst/article=2024/view=0
References
document.addEventListener(‘DOMContentLoaded’,function(){frmFrontForm.scrollToID(‘frm_container_ref_110445’);});Edit
- Codocedo JF, Inestrosa NC. Environmental control of microRNAs in the nervous system: Implications in plasticity and behavior. Neuroscience & Biobehavioral Reviews. 2016 Jan 1;60:121-38.
- Mallick A. MicroRNA. InEncyclopedia of Animal Cognition and Behavior 2022 May 20 (pp. 4293-4296). Cham: Springer International Publishing.
- Cardoso SD, Teles MC, Oliveira RF. Neurogenomic mechanisms of social plasticity. Journal of Experimental Biology. 2015 Jan 1;218(1):140-9.
- Bahlakeh G, Gorji A, Soltani H, Ghadiri T. MicroRNA alterations in neuropathologic cognitive disorders with an emphasis on dementia: Lessons from animal models. Journal of cellular physiology. 2021 Feb;236(2):806-23.
- Rajasethupathy P. Novel Small-RNA Mediated Gene-Regulatory Mechanisms for Long-term Memory. Columbia University; 2012.
- Kołosowska KA, Schratt G, Winterer J. microRNA-dependent regulation of gene expression in GABAergic interneurons. Frontiers in Cellular Neuroscience. 2023 May 5;17:1188574.
- Quinn RK, Brown AL, Goldie BJ, Levi EM, Dickson PW, Smith DW, Cairns MJ, Dayas CV. Distinct miRNA expression in dorsal striatal subregions is associated with risk for addiction in rats. Translational psychiatry. 2015 Feb;5(2):e503-.
- Saab BJ, Mansuy IM. Neuroepigenetics of memory formation and impairment: the role of microRNAs. Neuropharmacology. 2014 May 1;80:61-9.
- Wang W, Kwon EJ, Tsai LH. MicroRNAs in learning, memory, and neurological diseases. Learning & Memory. 2012 Sep 1;19(9):359-68.
- Bredy TW, Lin Q, Wei W, Baker-Andresen D, Mattick JS. MicroRNA regulation of neural plasticity and memory. Neurobiology of learning and memory. 2011 Jul 1;96(1):89-94.
- Busto GU, Guven-Ozkan T, Davis RL. MicroRNA function in Drosophila memory formation. Current opinion in neurobiology. 2017 Apr 1;43:15-24.
- Bitetti A, Mallory AC, Golini E, Carrieri C, Carreño Gutiérrez H, Perlas E, Perez-Rico YA, Tocchini-Valentini GP, Enright AJ, Norton WH, Mandillo S. MicroRNA degradation by a conserved target RNA regulates animal behavior. Nature structural & molecular biology. 2018 Mar;25(3):244-51.
- Mansur F, Ivshina M, Gu W, Schaevitz L, Stackpole E, Gujja S, Edwards YJ, Richter JD. Gld2-catalyzed 3′ monoadenylation of miRNAs in the hippocampus has no detectable effect on their stability or on animal behavior. Rna. 2016 Oct 1;22(10):1492-9.
- Issler O, Chen A. Determining the role of microRNAs in psychiatric disorders. Nature Reviews Neuroscience. 2015 Apr;16(4):201-12.
| Volume | |
| Received | 18/09/2024 |
| Accepted | 17/10/2024 |
| Published | 30/10/2024 |
function myFunction2() {
var x = document.getElementById(“browsefigure”);
if (x.style.display === “block”) {
x.style.display = “none”;
}
else { x.style.display = “Block”; }
}
document.querySelector(“.prevBtn”).addEventListener(“click”, () => {
changeSlides(-1);
});
document.querySelector(“.nextBtn”).addEventListener(“click”, () => {
changeSlides(1);
});
var slideIndex = 1;
showSlides(slideIndex);
function changeSlides(n) {
showSlides((slideIndex += n));
}
function currentSlide(n) {
showSlides((slideIndex = n));
}
function showSlides(n) {
var i;
var slides = document.getElementsByClassName(“Slide”);
var dots = document.getElementsByClassName(“Navdot”);
if (n > slides.length) { slideIndex = 1; }
if (n (item.style.display = “none”));
Array.from(dots).forEach(
item => (item.className = item.className.replace(” selected”, “”))
);
slides[slideIndex – 1].style.display = “block”;
dots[slideIndex – 1].className += ” selected”;
}