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Md. Emran Hossain*,
- Professor, Department of Animal Science and Nutrition, Chattogram Veterinary and Animal Sciences University, Khulshi, Chattogram, Bangladesh, , Bangladesh
Abstract
Nutrient sensing is a fundamental cellular process that enables animals to adapt to fluctuating dietary inputs while maintaining metabolic homeostasis and health. Recent advances reveal that the gut microbiota functions as an active metabolic partner, producing bioactive metabolites that directly influence host nutrient-sensing pathways and downstream cellular responses. This review synthesizes current knowledge on the integration of key signalling networks, including adenosine monophosphate activated protein kinase (AMPK), mechanistic target of rapamycin, and insulin signalling, with microbiota-derived cues such as short-chain fatty acids, bile acid derivatives, and amino acid metabolites. These interactions regulate critical cellular processes, including energy metabolism, immune function, oxidative stress responses, and epithelial integrity. Emerging evidence highlights a dynamic nutrient–microbiota–cell signalling axis that shapes physiological outcomes across multiple tissues. In livestock systems, this integrated framework has profound implications for growth efficiency, reproductive performance, disease resistance, and resilience to environmental stressors. Species- specific differences in microbiome composition and digestive physiology further modulate these responses, emphasizing the need for tailored nutritional strategies. Advances in omics technologies and molecular biotechnology are enabling deeper insights into host–microbiota interactions, facilitating the development of precision nutrition approaches that target specific signalling pathways. Despite significant progress, key mechanistic gaps remain in understanding the spatiotemporal coordination of nutrient sensing and microbial signalling under variable environmental conditions. Future research should prioritize multi-omics integration, longitudinal studies, and translational validation in production settings. Overall, integrating nutrient-sensing biology with microbiome science offers a transformative pathway for optimizing animal health and productivity in a rapidly changing climate.
Keywords: Animal health, cellular signalling, gut microbiota, metabolic homeostasis, nutrient sensing pathways
References
1. Guo Z, Yang J, Zang R, Yang Y, Wang Q, Xu C. The brain-gut-skin axis in inflammatory and disfiguring skin diseases: Mechanistic insights, clinical correlations, and therapeutic strategies. Front Immunol. 2026;17. doi: 10.3389/fimmu.2026.1737303.
2. Hasnah R, et al. A sensory map of the gastrointestinal tract. bioRxiv. 2025. Available from: http://biorxiv.org/lookup/doi/10.1101/2025.03.07.641228
3. Lazăr DC, et al. Gastric cancer and microbiota: Exploring the microbiome’role in carcinogenesis and treatment strategies. Life (Basel). 2025;15(7):999. doi: 10.3390/life15070999.
4. Kurhaluk N, Kołodziejska R, Kamiński P, Tkaczenko H. Integrative neuroimmune role of the parasympathetic nervous system, vagus nerve and gut microbiota in stress modulation: Anarrative review. Int J Mol Sci. 2025;26(23). doi: 10.3390/ijms262311706.
5. Chan M. Dissecting macrophage metabolism in metabolic liver disease [dissertation]. 2025. Available from: https://search.proquest.com/openview/b2724f37aa9e3acacd8100f4b88ba18f/1?pq origsite=gscholar&cbl=18750&diss=y
6. Ghobadinezhad F, et al. The emerging role of regulatory cell-based therapy in autoimmune disease. Front Immunol. 2022;13. doi: 10.3389/fimmu.2022.1075813.
7. Buffington S, Forsythe P, Hommel J, Laezza F, Oberhauser A. Diet- and probiotic-mediated modulation of the maternal gut microbiome impacts early-life programming of neurodevelopment and behavioral outcomes in offspring. 2022. Available from: https://utmb-ir.tdl.org/items/081077c7- d83d-4992-af65-4a6208bae3fe
8. Abu Y, Roy S. Intestinal dysbiosis during pregnancy and microbiota-associated impairments in offspring. Front Microbiomes. 2025;4. doi: 10.3389/frmbi.2025.1548650.
9. Hamamah S, Hajnal A, Covasa M. Influence of bariatric surgery on gut microbiota composition and its implication on brain and peripheral targets. Nutrients. 2024;16(7). doi: 10.3390/nu16071071.
10. Xia J, et al. Resynchronized rhythmic oscillations of gut microbiota drive time-restricted feeding- induced nonalcoholic steatohepatitis alleviation. Gut Microbes. 2023;15(1). doi: 10.1080/ 19490976.2023.2221450.
11. Drosophila melanogaster Head, et al. Identification of microbiota-induced gene expression changes in the Drosophila melanogaster head. bioRxiv. 2019:561043. doi: 10.1101/561043.
12. Ros MÁL. The immunomodulatory effect of the diet: Implications for health and disease [dissertation]. 2019. Available from: https://repositorio.unican.es/xmlui/handle/10902/16616
13. Wang J, et al. Tannic acid ameliorates systemic glucose and lipid metabolic impairment induced by low-dose T-2 toxin exposure. J Agric Food Chem. 2023;71(33):12574–12586. doi: 10.1021/ acs.jafc.3c02934.
14. Qiao K, et al. The complex interplay of insulin resistance and metabolic inflammation in transition dairy cows. Animals (Basel). 2024;14(6):832. doi: 10.3390/ani14060832.
15. Jacobo-Velázquez DA. Ferulic acid: Mechanistic insights and multifaceted applications in metabolic syndrome, food preservation, and cosmetics. 2025. Available from: https://www.mdpi.com/1420- 3049/30/18/3716
16. Charles-Messance H, Mitchelson KAJ, et al. Regulating metabolic inflammation by nutritional modulation. 2020. Available from: https://www.sciencedirect.com/science/article/pii/S0091674920311696
17. Wang B, Zhang B, Zhou L, Li S, Li Z, Luo H. Multi-omics reveals diet-induced metabolic disorders and liver inflammation via microbiota-gut-liver axis. J Nutr Biochem. 2023;111. doi: 10.1016/j.jnutbio.2022.109183.
18. Thakur K, Zhu YY, Feng JY, Zhang JG, Hu F, et al. Morin as an imminent functional food ingredient: An update on its enhanced efficacy in the treatment and prevention of metabolic syndromes. Food Funct. 2020. Available from: https://pubs.rsc.org/en/content/articlehtml/2020/fo/d0fo01444c
19. Kwon H, Pessin JE. Insulin-mediated PI3K and AKT signalling. In: Liver Biology and Pathobiology. 2020. p. 485–495. doi: 10.1002/9781119436812.ch39.
20. Bayliak MM, Abrat OB. Role of Nrf2 in oxidative and inflammatory processes in obesity and metabolic diseases. Prog Inflamm Res. 2020;85:153–187. doi: 10.1007/978-3-030-44599-7_7.
21. Wang J, et al. Involvement of the VEGF signalling pathway in immunosuppression and hypoxia stress: Analysis of mRNA expression in lymphocytes mediating panting in Jersey cattle under heat stress. BMC Vet Res. 2021;17(1):209. doi: 10.1186/s12917-021-02912-y.
22. Yoo JY, Kim SS. Probiotics and prebiotics: Present status and future perspectives on metabolic disorders. Nutrients. 2016;8(3):173.
23. Leroy JLMR, et al. Negative energy balance and metabolic stress in relation to oocyte and embryo quality: An update on possible pathways reducing fertility in dairy cows. Anim Reprod. 2017;14(3):497–506. doi: 10.21451/1984-3143-AR992.
24. Piantoni P, Wang P, Drackley JK, Hurley WL, Loor JJ. Expression of metabolic, tissue remodeling, oxidative stress, and inflammatory pathways in mammary tissue during involution in lactating dairy cows. Bioinform Biol Insights. 2010;4:85–97. doi: 10.4137/BBI.S5850.
25. Guo S. Insulin signalling, resistance, and the metabolic syndrome: Insights from mouse models to disease mechanisms. 2014. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC4087161/
26. Marei WFA, De Bie J, Xhonneux I, Andries S, Britt JH, Leroy JLMR. Metabolic and antioxidant status during transition is associated with changes in the granulosa cell transcriptome in the preovulatory follicle in high-producing dairy cows at the time of breeding. 2022. doi: 10.3168/jds.2022-21928.
27. Wu CW, Storey K. mTOR signalling in metabolic stress adaptation. Biomolecules. 2021;11. doi: 10.3390/biom11050681.
28. Wu L, Ye S, Deng X, Fu Z, Li J, Yang C. Conjugated linoleic acid ameliorates high fat-induced insulin resistance via regulating gut microbiota-host metabolic and immunomodulatory interactions. Nutrients. 2024;16(8). doi: 10.3390/nu16081133.
29. Sun X, et al. Oxidative stress, NF-κB signalling, NLRP3 inflammasome, and caspase apoptotic pathways are activated in mammary gland of ketotic Holstein cows. J Dairy Sci. 2021;104(1):849– 861. doi: 10.3168/jds.2020-18788.
30. do Amaral BC, Connor EE, Tao S, Hayen MJ, Bubolz JW, Dahl GE. Heat stress abatement during the dry period influences metabolic gene expression and improves immune status in the transition period of dairy cows. 2011. doi: 10.3168/jds.2009-3004.
31. Srikanth K, et al. Transcriptome analysis and identification of significantly differentially expressed genes in Holstein calves subjected to severe thermal stress. Int J Biometeorol. 2017;61(11):1993–2008. doi: 10.1007/s00484-017-1392-3.
32. Naser AN, Lu Q, Chen YH. Trans-compartmental regulation of tight junction barrier function. Tissue Barriers. 2023;11(4). doi: 10.1080/21688370.2022.2133880.
33. Shehata AA, et al. Probiotics, prebiotics, and phytogenic substances for optimizing gut health in poultry. Microorganisms. 2022;10(2):395. doi: 10.3390/microorganisms10020395.
34. Gao J, et al. Impact of the gut microbiota on intestinal immunity mediated by tryptophan metabolism. Front Cell Infect Microbiol. 2018. doi: 10.3389/fcimb.2018.00013.
35. Suyama R, Cetraro N, Yew JY, Kai T. Microbes control Drosophila germline stem cell increase and egg maturation through hormonal pathways. Commun Biol. 2023. doi: 10.1038/s42003- 023-05660-x.
36. do Amaral BC, Connor EE, Tao S, Hayen J, Bubolz J, Dahl GE. Heat-stress abatement during the dry period: Does cooling improve transition into lactation? J Dairy Sci. 2009;92(12):5988–5999. doi: 10.3168/jds.2009-2343.
37. Hamamah S, Amin A, Al-Kassir AL, Chuang J, et al. Dietary fat modulation of gut microbiota and impact on regulatory pathways controlling food intake. Nutrients. 2023. Available from: https://www.mdpi.com/2072–6643/15/15/3365
38. Saadat YR, Barzegari A, Saadatian Z, et al. Gut microbiota and kidney aging: Insights into current research. 2025. doi: 10.1186/s12986-025-01032-w.
39. Cai H, et al. Gut microbiota supports male reproduction via nutrition, immunity, and signalling. Front Microbiol. 2022. doi: 10.3389/fmicb.2022.977574.
40. Tao P, Ji J, Wang Q, Cui M, Cao M, Xu Y. The role and mechanism of gut microbiota-derived short-chain fatty acids in the prevention and treatment of diabetic kidney disease. Front Immunol. 2022. doi: 10.3389/fimmu.2022.1080456.
41. Fan Y, Qin M, Zhu J, Chen X, Luo J, et al. MicroRNA sensing and regulating microbiota-host crosstalk via diet motivation. Crit Rev Food Sci Nutr. 2024. doi: 10.1080/10408398.2022.2139220.
42. Ma N, et al. Disturbances of ruminal microbiota and liver inflammation, mediated by LPS and histamine, in dairy cows fed a high-concentrate diet. Animals (Basel). 2024;14(10):1495. doi: 10.3390/ani14101495.
43. Moeller AH, Sanders JG. Roles of the gut microbiota in the adaptive evolution of mammalian species. Philos Trans R Soc Lond B Biol Sci. 2020;375(1808). doi: 10.1098/rstb.2019.0597.
44. Yu M, Yu B, Chen D. The effects of gut microbiota on appetite regulation and the underlying mechanisms. Gut Microbes. 2024;16(1):2414796. doi: 10.1080/19490976.2024.2414796.
45. Basangwangdui QZ, Dang S, et al. Yak rumen microbiota structure. In: Animal Social Behavior and Welfare. 2023. Available from: https://books.google.com/books?hl=en&lr=&id=nnHVEAAA QBAJ&oi=fnd&pg=PA111&dq=%22diet+gene%22+interactions+in+farm+animals+molecular+dyna mics+of+nutrient+utilization+gene+expression+and+signalling+pathways&ots=CiQJXs3NYc&sig=q 35AtAVtqzKbe8L4R2LDCaYE1u4
46. Ma S, et al. Roughage quality determines the production performance of post-weaned Hu sheep via altering ruminal fermentation, morphology, microbiota, and the global methylome landscape of the rumen wall. Front Microbiomes. 2024. doi: 10.3389/frmbi.2023.1272625.
47. Li C, Wang F, Mao Y, Ma Y, Guo Y. Multi-omics reveals the mechanism of trimethylamine N- oxide derived from gut microbiota inducing liver fatty of dairy cows. BMC Genomics. 2025;26(1):10. doi: 10.1186/s12864-024-11067-7.
48. Cao C, Chowdhury VS, Cline MA, Gilbert ER. The microbiota-gut-brain axis during heat stress in chickens: A review. Front Physiol. 2021;12. doi: 10.3389/fphys.2021.752265.
49. Lin L, et al. Genome-centric investigation of bile acid metabolizing microbiota of dairy cows and associated diet-induced functional implications. ISME J. 2023;17(1):172–184. doi: 10.1038/ s41396-022-01333-5.
50. Lu Z, Shen H, Shen Z. Effects of dietary SCFA on microbial protein synthesis and urinary urea- N excretion are related to microbiota diversity in rumen. Front Physiol. 2019. doi: 10.3389/fphys.2019.01079.
51. Chi L, Tu P, Ru H, Lu K. Studies of xenobiotic-induced gut microbiota dysbiosis: From correlation to mechanisms. Gut Microbes. 2021;13(1). doi: 10.1080/19490976.2021.1921912.
52. Tong Y, Lou X. Interplay between bile acids, gut microbiota, and the tumor immune microenvironment: Mechanistic insights and therapeutic strategies. Front Immunol. 2025. doi: 10.3389/fimmu.2025.1638352.
53. Edo GI, Mafe AN, Ali ABM, Akpoghelie PO, Yousif E, et al. Mechanistic insights into β-glucans and gut microbiota interactions for enhancing human health. 2025. doi: 10.1007/s44187-025- 00503-6.
54. Rio P, Gasbarrini A, Gambassi G, Cianci R. Pollutants, microbiota and immune system: Frenemies within the gut. Front Public Health. 2024;12:1285186. doi: 10.3389/fpubh.2024.1285186.
55. Haider K, Abbas D, Galian J, Ghafar MA, et al. The multifaceted roles of gut microbiota in insect physiology, metabolism, and environmental adaptation: Implications for pest management strategies. World J Microbiol Biotechnol. 2025. doi: 10.1007/s11274-025-04288-9.
56. Guney C, Bal NB, Akar F. The impact of dietary fructose on gut permeability, microbiota, abdominal adiposity, insulin signalling and reproductive function. Heliyon. 2023. doi: 10.1016/j.heliyon.2023.e18896.
57. Mora PE, Valbuena D, Diez-Juan A. The role of the gut microbiota in female reproductive and gynecological health: Insights into endometrial signalling pathways. Life (Basel). 2025;15(5):762. Available from: https://www.mdpi.com/2075–1729/15/5/762
58. Tao Y, Wang Z, Wang Q, Zhong S. Multifactorial mechanisms and therapeutic role of the gut microbiota in sarcopenic obesity: Role of lifestyle and gut microbiota-derived metabolites. Nutr Rev. 2026. doi: 10.1093/nutrit/nuaf274/8424279.
59. Zhao X, Shi W, Li Z, Zhang W. Linking reproductive tract microbiota to premature ovarian insufficiency: Pathophysiological mechanisms and therapies. J Reprod Immunol. 2024;166. doi: 10.1016/j.jri.2024.104325.
60. Wu D, et al. Reproductive hormones mediate intestinal microbiota shifts during estrus synchronization in grazing Simmental cows. Animals (Basel). 2022. doi: 10.3390/ani12141751.
61. Liu JB, Chen K, Li ZF, Wang ZY, Wang L. Glyphosate-induced gut microbiota dysbiosis facilitates male reproductive toxicity in rats. Sci Total Environ. 2022;805. doi: 10.1016/j.scitotenv.2021.150368.
62. Wen S, Zhao Y, Liu S, Yuan H, You T, Xu H. Microplastics-perturbed gut microbiota triggered the testicular disorder in male mice: Via fecal microbiota transplantation. Environ Pollut. 2022;309. doi: 10.1016/j.envpol.2022.119789.
63. Wang K, et al. Diet with a high proportion of rice alters profiles and potential function of digesta-associated microbiota in the ileum of goats. Animals (Basel). 2020;10(8):1261. doi: 10.3390/ani10081261.
64. Tao W, Zhu W, Nabi F, Li Z, Liu J. Penthorum chinense Pursh compound flavonoids supplementation alleviates aflatoxin B1-induced liver injury via modulation of intestinal barrier and gut microbiota in broiler. Ecotoxicol Environ Saf. 2023;255:114805. doi: 10.1016/j.ecoenv.2023.114805.
65. Muñoz E, Fuentes F, Felmer R, Arias ME, Yeste M. Effects of reactive oxygen and nitrogen species on male fertility. Antioxid Redox Signal. 2024;40(13–15):802–836. doi: 10.1089/ars.2022.0163.
66. Abdulqadir R, Engers J, Al-Sadi R. Role of Bifidobacterium in modulating the intestinal epithelial tight junction barrier: Current knowledge and perspectives. Curr Dev Nutr. 2023. doi: 10.1016/j.cdnut.2023.102026.
67. Liu WC, et al. Effects of heat stress on production performance, redox status, intestinal morphology and barrier-related gene expression, cecal microbiome, and metabolome in indigenous broiler chickens. Front Physiol. 2022. doi: 10.3389/fphys.2022.890520.
68. Bustani G, Alghetaa H, Mohammed A, Nagarkatti M, Nagarkatti P. The aryl hydrocarbon receptor: A new frontier in male reproductive system. 2025. doi: 10.1186/s12958-025-01401-3.
69. Xu H, et al. Integrative multi-omics and bioinformatics analysis of the effects of BaiRui YuPingFeng Powder on intestinal health in broilers. Front Vet Sci. 2025;12:1606531. doi: 10.3389/fvets.2025.1606531.
70. Rani K, Kaur G, Ali SA. Probiotic-prebiotic therapeutic potential: A new horizon of microbial biotherapy to reduce female reproductive complications. PharmaNutrition. 2023;24. doi: 10.1016/ j.phanu.2023.100342.
71. Tretiak S, et al. Proteomic profiling of dysbiosis-challenged broilers reveals potential blood biomarkers for intestinal health. Vet Res. 2025;56(1):143. doi: 10.1186/s13567-025-01570-4.
72. Matsuyama S, DeFalco T. Steroid hormone signalling: Multifaceted support of testicular function. Front Cell Dev Biol. 2023;11:1339385. doi: 10.3389/fcell.2023.1339385.
73. Singh PS, et al. Volatile compounds-mediated hormonal signalling and crosstalk with plant growth- promoting microbes. In: Hormonal Cross-Talk in Plant Defense and Development: Plant Biology for Sustainable Climate Change. 2023. p. 295–304. doi: 10.1016/B978-0-323-95375-7.00013-6.
74. Sigdel A, Bisinotto RS, Peñagaricano F. Genes and pathways associated with pregnancy loss in dairy cattle. Sci Rep. 2021;11(1):13329. doi: 10.1038/s41598-021-92525-0.
75. McClure R, Massari P. TLR-dependent human mucosal epithelial cell responses to microbial pathogens. Front Immunol. 2014. doi: 10.3389/fimmu.2014.00386.
76. Oladejo AO, et al. Modulation of bovine endometrial cell receptors and signalling pathways as a nanotherapeutic exploration against dairy cow postpartum endometritis. Animals (Basel). 2021;11(6):1516. doi: 10.3390/ani11061516.
77. Jauregi-Miguel A. The tight junction and the epithelial barrier in coeliac disease. Int Rev Cell Mol Biol. 2021;358:105–132. doi: 10.1016/bs.ircmb.2020.09.010.
78. Onyango AN. Cellular stresses and stress responses in the pathogenesis of insulin resistance. Oxid Med Cell Longev. 2018;2018:4321714. doi: 10.1155/2018/4321714.
79. Benedetti M, Giuliani ME, Regoli F. Oxidative metabolism of chemical pollutants in marine organisms: Molecular and biochemical biomarkers in environmental toxicology. Ann N Y Acad Sci. 2015;1340(1):8–19. doi: 10.1111/nyas.12698.
80. Limón-Pacheco J, Gonsebatt ME. The role of antioxidants and antioxidant-related enzymes in protective responses to environmentally induced oxidative stress. Mutat Res Genet Toxicol Environ Mutagen. 2009;674(1–2):137–147. doi: 10.1016/j.mrgentox.2008.09.015.
81. Arora R, et al. Transcriptomics reveals key genes responsible for functional diversity in pectoralis major muscles of native black Kadaknath and broiler chicken. 3 Biotech. 2023;13(7):253. doi: 10.1007/s13205-023-03682-0.
82. Obianwuna UE, et al. Phytobiotics in poultry: Revolutionizing broiler chicken nutrition with plant-derived gut health enhancers. J Anim Sci Biotechnol. 2024;15(1):169. doi: 10.1186/s40104- 024-01101-9.
83. Losacco C, Pugliese G, Forte L, Tufarelli V, Maggiolino A, De Palo P. Digital transition as a driver for sustainable tailor-made farm management: An up-to-date overview on precision livestock farming. Agriculture. 2025;15(13). doi: 10.3390/agriculture15131383.
84. Giannuzzi D, et al. Milk phenomics: Leveraging biological bonds with blood and infrared technologies for evaluating animal nutritional and health status. Ital J Anim Sci. 2024;23(1):780– 801. doi: 10.1080/1828051X.2024.2353226.
85. Nawab A, et al. Evaluation of precision feeding to enhance broiler growth performance. Animals (Basel). 2025;15(16):2433. doi: 10.3390/ani15162433.
86. Prasetya F, Hananta L. Nutrigenomics and Jamu: Integrating nutritional genomics with Indonesian traditional medicine for precision, preventive, and systems-oriented health. J Trop Pharm Chem. 2025. Available from: http://jtpc.ff.unmul.ac.id/index.php/jtpc/article/view/320
87. Fushai F, Chitura T, Oke OE. Climate-smart livestock nutrition in semi-arid Southern African agricultural systems. Front Vet Sci. 2025;12:57–87. doi: 10.3389/fvets.2025.1507152.
88. Zhang S, Lai C, Zhao J, Wang J. Big data and AI-powered modeling: A pathway to sustainable precision animal nutrition. Adv Sci (Weinh). 2025;12(41). doi: 10.1002/advs.202507564.
89. Keohavong B. Digital innovation integration into biotechnology for development of sustainable protein frontiers for poultry nutrition in a circular bioeconomy. Poult Sci. 2026;105(2). doi: 10.1016/j.psj.2025.106276.
90. Nasar S, et al. OMICS-based knowledge for achieving food and nutritional security. In: Omics Techniques for Global Food Security. 2024;2(1):67–90. doi: 10.1002/9781394209156.ch4.
91. Borsoi FT, Alves LF, et al. A multi-omics approach to understand the influence of polyphenols in ovarian cancer for precision nutrition: A mini-review. Crit Rev Food Sci Nutr. 2025. doi: 10.1080/10408398.2023.2287701.
92. Pomar C, van Milgen J, Remus A. Precision livestock feeding, principle and practice. In: Poultry and Pig Nutrition. Wageningen: Wageningen Academic Publishers; 2019. p. 397–418. doi: 10.3920/978-90-8686-884-1_18.
93. Zhang S, Lai C, Zhao J, Wang J. Big data and AI-powered modeling: A pathway to sustainable precision animal nutrition. Adv Sci (Weinh). 2025. doi: 10.1002/advs.202507564.
94. Kang JW, Zivkovic AM. Are eggs good again? A precision nutrition perspective on the effects of eggs on cardiovascular risk, taking into account plasma lipid profiles and TMAO. J Nutr Biochem. 2022;100:108906. doi: 10.1016/j.jnutbio.2021.108906.
95. Kogut MH. Role of diet-microbiota interactions in precision nutrition of the chicken: Facts, gaps, and new concepts. Poult Sci. 2022;101(3):101673. doi: 10.1016/j.psj.2021.101673.
96. Quan W, Zhou J, Wang J, Huang J, Du L. Machine learning-driven precision nutrition: Aparadigm evolution in dietary assessment and intervention. Nutrients. 2025;18(1):45. Available from: 10.1016/j.psj.2021.101673.
97. Hotea I, Dragomirescu M, Berbecea A, Radulov I. The role of nutrition in enhancing sustainability in sheep production. 2023. doi: 10.5772/intechopen.113938.
98. Unger AL, et al. Harnessing the magic of the dairy matrix for next-level health solutions: A summary of a symposium presented at Nutrition 2022. Curr Dev Nutr. 2023. doi: 10.1016/j.cdnut.2023.100105.
99. El-Hack MEA, Allam AA, Aldhalmi AK, et al. Integrating metabolomics for precision nutrition in poultry: Optimizing growth, feed efficiency, and health. Front Vet Sci. 2025. doi: 10.3389/ fvets.2025.1594749.
100. Gao Y, et al. Fermented dairy products as precision modulators of gut microbiota and host health: Mechanistic insights, clinical evidence, and future directions. Foods. 2025;14(11):1946. Available from: https://www.mdpi.com/2304–8158/14/11/1946
101. Kaur U, et al. Invited review: Integration of technologies and systems for precision animal agriculture— A case study on precision dairy farming. J Anim Sci. 2023;101. doi: 10.1093/jas/skad206.
International Journal of Molecular Biotechnological Research
| Volume | 04 | |
| 02 | ||
| Received | 27/04/2026 | |
| Accepted | 05/05/2026 | |
| Published | 15/05/2026 | |
| Publication Time | 18 Days |