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Prof. (Dr.) ATUL KHAJURIA,
Ashish Kumar,
Prabhdeep Singh,
- Dean, Faculty of Allied & Healthcare Sciences Rayat Bahra Professional University, Hoshiarpur, Punjab, India
- Assistant Professor, Faculty of Allied & Healthcare Sciences Rayat Bahra Professional University, Hoshiarpur, Punjab, India
- Assistant Professor, Faculty of Allied and Healthcare Sciences Rayat Bahra Profession University VPO BOHAN, Tehsil & Distt. Hoshiarpur, Punjab, 146001, Punjab, India
Abstract
Next-generation biorepositories have emerged as critical infrastructure for advancing infectious disease research and accelerating vaccine development. By integrating cellular, genomic, and clinical data within harmonized frameworks, these repositories overcome traditional limitations of fragmented datasets and limited interoperability. The evolution from conventional biobanks to digitally enabled, multi-omics platforms has enabled comprehensive analysis of pathogen–host interactions, facilitating the identification of novel vaccine targets and correlates of protection. The COVID-19 pandemic underscored the importance of rapid-access, high-quality biospecimen repositories, leading to the establishment of global networks that support real-time outbreak response and collaborative research. Advanced technologies, including artificial intelligence, next-generation sequencing, and automated cryostorage systems, have further enhanced data annotation, sample integrity, and scalability. Despite these advancements, challenges such as data heterogeneity, ethical concerns, privacy regulations, and sustainability remain significant. Harmonization strategies, federated data models, and adherence to international standards such as ISBER and ISO 20387 provide viable solutions. This review highlights the transformative role of next-generation biorepositories in infectious disease management, emphasizing their contributions to vaccine discovery, global health preparedness, and precision vaccinology.
Keywords: Next-generation biorepositories; Infectious diseases; Vaccine development; Multi-omics integration; Data harmonization; Biobanking standards; Genomic data; Clinical data integration; Precision vaccinology; Artificial intelligence; Cryopreservation; Global health infrastructure
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International Journal of Vaccines
| Volume | 03 | |
| 02 | ||
| Received | 08/04/2026 | |
| Accepted | 28/05/2026 | |
| Published | 08/06/2026 | |
| Publication Time | 61 Days |