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Dipali S. Mankar,
Sanjesh Sadanand Pawale,
Pugazhendhi S,
Naveen Jain,
ANUDEEP MEDA,
M Sunil Raj,
- Associate Professor, Department of Engineering, PCETs, Pimpri Chinchwad University, Pune, Maharashtra, India
- Associate Professor, Department of Computer Engineering, Vishwakarma University, Pune, Maharashtra, India
- Associate Professor, Department of Pharmacology, Meenakshi College of Pharmacy, Meenakshi Academy of Higher Education and Research, Mevalurkuppam, Tamil Nadu, India
- Associate Professor, Department of Mechanical Engineering, Shri Shankaracharya Institute of Professional Management & Technology, Raipur, Chhattisgarh, India
- Associate Professor, Department of Computer Science and Engineering (AI&ML), Vardhaman College of Engineering, Shamshabad, Hyderabad, Telangana, India
- Associate Professor, Department of Mechanical Engineering, Pragati Engineering College, Kakinada District, Andhra Pradesh, India
Abstract
Artificial Intelligence (AI) has already become a ground-breaking tool of streamlining polymer composite implants to enhance both mechanical strength and biocompatibility simultaneously. This paper recommend an AI-based multi-objective optimization model, which integrates the selection of materials, structural modelling, and biological evaluation. The in vitro biocompatibility indicators, including cytotoxicity and cell adhesion, can be used to model mechanical behavior, e.g. stress-strain behavior and fatigue behavior. To arrive at an optimal material compositions and processing parameters, the use of advanced algorithms which includes genetic algorithms, neural networks etc are used. Experimental validation shows an improved performance trade-off and therefore has been more stable and biological compatible hence contributing to the creation of next-generation implantable biomedical devices with a dependable performance. The proposed framework incorporates the material selection, predictive modelling and multi-objective optimization to arrive at the optimal design configurations. The methodology is supported by the findings that demonstrated significant advances of strength, fatigue resistance and bio-compatibility. The fact that it can be used as the solution to conflicting requirements at the same time makes the implants more reliable and medically applicable. Furthermore, AI-related methods guarantee that time and money wasted in experiments are reduced, as well as increase accuracy. The future of work can be addressed in terms of the adaptive optimization and integration of the advanced manufacturing methodology that can be further added to the personalized design of implants and biomedical results in real-time.
Keywords: Artificial Intelligence, Polymer Composite Implants, Mechanical Properties, Biocompatibility, Multi-objective Optimization, Genetic Algorithms.
References
- Song, L.; Wang, D.; Liu, X.; Yin, A.; Long, Z. Prediction of mechanical properties of composite materials using multimodal fusion learning. Sens. Actuators A Phys. 2023, 358, 114433.
- Yu, Z.; Ye, S.; Sun, Y.; Zhao, H.; Feng, X.Q. Deep learning method for predicting the mechanical properties of aluminum alloys with small data sets. Mater. Today Commun. 2021, 28, 102570.
- Mishra, S.K.; Brahma, A.; Dutta, K. Prediction of mechanical properties of Al-Si-Mg alloy using artificial neural network. Sadhana-Acad. Proc. Eng. Sci. 2021, 46, 139.
- Tran, H.D.; Kim, C.; Chen, L.; Chandrasekaran, A.; Batra, R.; Venkatram, S.; Kamal, D.; Lightstone, J.P.; Gurnani, R.; Shetty, P.; et al. Machine-learning predictions of polymer properties with Polymer Genome. J. Appl. Phys. 2020, 128, 171104.
- Han, T.; Huang, J.; Sant, G.; Neithalath, N.; Kumar, A. Predicting mechanical properties of ultrahigh temperature ceramics using machine learning. J. Am. Ceram. Soc. 2022, 105, 6851–6863.
- Béji, H.; Kanit, T.; Messager, T. Prediction of Effective Elastic and Thermal Properties of Heterogeneous Materials Using Convolutional Neural Networks. Appl. Mech. 2023, 4, 287–303.
- Balasundaram, R.; Devi, S.S.; Balan, G.S. Machine learning approaches for prediction of properties of natural fiber composites: Apriori algorithm. Aust. J. Mech. Eng. 2022, 20, 30091.
- Zhu, J.; Jia, Y.; Lei, J.; Liu, Z. Deep learning approach to mechanical property prediction of single-network hydrogel. Mathematics 2021, 9, 2804.
- Khobragade, Prashant , Gandal, Ganesh , Somatkar, Avinash , Panchabudhe, Hrushikesh Madhukar , Ashok, Phatangare Prashant & Madaminov, Bekzod. (2026) Heat transfer modeling using fractional differential equations, Journal of Interdisciplinary Mathematics, 29:3, 749–756, DOI: 47974/JIM-2511.
- Chan, C.H.; Sun, M.; Huang, B. Application of machine learning for advanced material prediction and design. EcoMat 2022, 4, e12194.
- Guo, K.; Yang, Z.; Yu, C.H.; Buehler, M.J. Artificial intelligence and machine learning in design of mechanical materials. Mater. Horizons 2021, 8, 1153–1172.
- Bhattacharya, S.; Kalita, K.; Čep, R.; Chakraborty, S. A comparative analysis on prediction performance of regression models during machining of composite materials. Materials 2021, 14, 6689.
- Lyu, F.; Fan, X.; Ding, F.; Chen, Z. Prediction of the axial compressive strength of circular concrete-filled steel tube columns using sine cosine algorithm-support vector regression. Compos. Struct. 2021, 273, 114282.
- Zhang, C.; Li, Y.; Jiang, B.; Wang, R.; Liu, Y.; Jia, L. Mechanical properties prediction of composite laminate with FEA and machine learning coupled method. Compos. Struct. 2022, 299, 116086.
- S.Matey , C. N. Sakhale, G. D. Mehta, and S. D. Shelare, “Enhancing Heat Transfer with Electro-Hydro-Dynamic Techniques: Challenges, Limitations, and Future Directions”, IJTARME, vol. 14, no. 1, pp. 51–66, May 2025.
- Karamov, R.; Akhatov, I.; Sergeichev, I.V. Prediction of Fracture Toughness of Pultruded Composites Based on Supervised Machine Learning. Polymers 2022, 14, 3619.

Journal of Polymer & Composites
| Volume | 14 | |
| 04 | ||
| Received | 01/05/2026 | |
| Accepted | 13/07/2026 | |
| Published | 25/08/2026 | |
| Publication Time | 116 Days |