Antibacterial Nanocoatings for Orthodontic Braces and Clear Aligners: Synthesis, Mechanisms, and Translational Potential

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Year : 2026 | Volume : 17 | Issue : 02 | Page : 7 17
By

Atul Khajuria,

Sukhmeet Kaur Bedi,

  1. Dean & Professor, Department of Allied & Healthcare Sciences, Rayat Bahra Professional University, Hoshiarpur, Punjab, India
  2. Dental Surgeon, Department of Allied & Health Care Sciences, Rayat Bahra Professional University, Hoshiarpur, Punjab, India

Abstract

Orthodontic brackets, archwires and clear aligners create retentive sites that favor biofilm accumulation, leading to white-spot lesions, enamel demineralization and gingival inflammation during treatment. Conventional chemomechanical plaque control has limited effectiveness in this high-risk environment, especially in adolescents with poor compliance. Antibacterial nanocoatings on metallic and polymeric orthodontic components have emerged as a promising strategy to locally suppress cariogenic and periodontopathogenic biofilms while preserving mechanical performance and esthetics. This review summarizes the state of the art in antibacterial nanocoatings for stainless-steel and ceramic brackets, NiTi archwires and clear aligner materials, with emphasis on synthesis routes, structure– property relationships, in vitro and in vivo performance, and translational challenges. We discuss metallic (Ag, Cu, ZnO), metal-oxide hybrid, graphene-based and polymer-grafted nanocoatings, highlighting how process parameters – such as particle size, loading, film thickness and binding chemistry – modulate biofilm inhibition, ion release, and durability under oral conditions. Particular attention is given to clear aligner systems incorporating bioactive nanofillers or antifouling zwitterionic monomers to minimize surface biofouling without compromising transparency. Regulatory, toxicological and clinical trial considerations are reviewed, including ion leaching, color stability, wear, and compatibility with routine disinfection and sterilization workflows. Finally, we outline future directions, such as smart and stimuli-responsive antibacterial coatings, integration with remineralizing nanophases, and standardized methodologies, for long-term in vivo evaluation in orthodontic patients.

Keywords: Orthodontic appliances, antibacterial nanocoatings, biofilm inhibition, clear aligners, orthodontic brackets, archwires, nanotechnology

[This article belongs to Research and Reviews: A Journal of Dentistry ]

How to cite this article: Atul Khajuria, Sukhmeet Kaur Bedi. Antibacterial Nanocoatings for Orthodontic Braces and Clear Aligners: Synthesis, Mechanisms, and Translational Potential. Research and Reviews: A Journal of Dentistry. 2026; 17(02):7-17.
How to cite this URL: Atul Khajuria, Sukhmeet Kaur Bedi. Antibacterial Nanocoatings for Orthodontic Braces and Clear Aligners: Synthesis, Mechanisms, and Translational Potential. Research and Reviews: A Journal of Dentistry. 2026; 17(02):7-17. Available from: https://journals.stmjournals.com/rrjod/article=2026/view=253168

References

  1. Wang NN, Yu JJ, Yan JR, Hua F. Recent advances in antibacterial coatings for orthodontic appliances. Front Bioeng Biotechnol. 2023;11:1093926.
  2. Ashith MV, Rao MM, Nambiar S, Shetty A, Shenoy R, Pai S. Antibacterial coatings for orthodontic materials: A review. J Int Dent Med Res. 2023;16(2):610–8.
  3. Costa A, Silva R, Oliveira P, Martins M, Pinto N, Gomes L, et al. Antibacterial efficacy of nanoparticles on orthodontic materials: A systematic review. Orthod Craniofac Res. 2025;28(1):3–18.
  4. Grumezescu AM, Enache DF, Popa M, Iordache F, Voicu G, Stan MS, et al. Antimicrobial nanocoatings in medicine and dentistry. Nanomaterials (Basel). 2023;13(4):695.
  5. Wang X, Zhou Y, Li H, Chen L, Zhang Y, Liu J, et al. Functional surface coatings on orthodontic appliances: Reviews of friction reduction, antibacterial properties, and corrosion resistance. Materials (Basel). 2023;16(7):2675.
  6. Atik E, Akarsu S, Akkaya S, Ciftci Z, Büyük SK, Oztürk F. Nanosilver coated orthodontic brackets: In vivo antibacterial effects and ion release. Eur J Orthod. 2017;39(1):9–15.
  7. Zeidan O, Dey S, Elmasry M, Gupta M, Raghavan S, Nair S, et al. Zinc oxide nanoparticle coated orthodontic brackets: Antibacterial effect and surface characteristics. Angle Orthod. 2022;92(3):381–9.
  8. Ramazanzadeh B, Golshah A, Ghorbani F, Beigi P, Sharifi S, Esmailzadeh S. Hybrid nano coating of orthodontic brackets with metal and metal oxide nanoparticles: An in vitro study. J Contemp Dent Pract. 2024;25(4):345–53.
  9. Nalini S, Reddy P, Rao MV, Prasad M, Thomas B, Nair R, et al. Antibacterial efficacy and surface roughness of nanoparticle coated orthodontic brackets. Int J Orthod Rehabil. 2025;12(3):150–8.
  10. Kaur R, Sharma S, Gupta A, Kakkar A, Mehta S, Narang R. Antibacterial effect of nanoparticle incorporated orthodontic primer against oral biofilm. J Indian Orthod Soc. 2024;58(1):60–7.
  11. Li Y, Zhang L, Chen T, Huang X, Wu Q, Wang Y. Study on the role of nano antibacterial materials in orthodontics: A review. Saudi Dent J. 2024;36(2):120–9.
  12. Wang J, Liu H, Chen Y, Li X, Zhang Q, Sun L, et al. Study on the antibacterial properties and optical performance of ZnO and MgO nanoparticle coated clear aligners. J Dent. 2025;143:104752.
  13. Zhang X, Wang Y, Li Y, Zhao L, Chen J, Liu Z. Bio inspired nanocomposite coatings on orthodontic archwires with corrosion resistant and antibacterial properties. Front Bioeng Biotechnol. 2023;11:1272527.
  14. Lee JH, Kim HE, Choi SH, Han JS, Jang JH, Kim YK. Comprehensive evaluation of the antibacterial and corrosion behavior of silver nanoparticle coated orthodontic wires. BMC Oral Health. 2024;24(1):650.
  15. Wang Y, Chen L, Zhou Y, Zhang X, Liu J, Li H, et al. Nanoparticle modified orthodontic archwires: Antibacterial activity and frictional behavior. Prog Orthod. 2024;25(1):15.
  16. Zhang K, Wang S, Li X, Cheng L, Xu H, Weir MD, et al. Novel antimicrobial and bioactive resin based clear aligner attachment material containing nano amorphous calcium phosphate and DMADDM. Dent Mater. 2025;41(2):e45–e56.
  17. Kwon JS, Lee MJ, Kim JH, Choi SH, Kim YK, Lee JH. Enhanced anti microbial properties of clear aligner resin containing 2 methacryloyloxyethyl phosphorylcholine. J Dent Res. 2025;104(7):780–8.
  18. Chen S, Li J, Zhang Y, Liu X, Wang H, Yang F, et al. Antibacterial and fluorescent clear aligner attachment resin modified with ZnO quantum dots and chlorhexidine loaded mesoporous silica nanoparticles. J Dent. 2024;139:104668.
  19. Silva R, Costa A, Martins M, Oliveira P, Pinto N, Gomes L. Systematic review of antibacterial effects of nanoparticles in clear overlay orthodontic appliances. J Stomatol Oral Maxillofac Surg. 2025;124(8):e1–e10.
  20. Grigalauskaite A, Zubiene J, Linkeviciene L, Rimkeviciene J, Peciuliene V, Ostrauskas R, et al. Nanoparticles in orthodontic materials: An umbrella review of systematic reviews and meta analyses. Int J Environ Res Public Health. 2025;22(6):5120.
  21. Costa A, Silva R, Martins M, Oliveira P, Pinto N, Gomes L. Nanoparticles in orthodontics to prevent white spot lesions: An umbrella review. Clin Oral Investig. 2025;29(5):2551–65.
  22. Wang J, Yu J, Yan Z, Hua F. Antibacterial coatings for orthodontic appliances: Mechanisms, classification, and preparation methods. Int J Mol Sci. 2024;25(10):5123.
  23. Ramazanzadeh B, Esmailzadeh S, Ghorbani F, Golshah A, Beigi P, Sharifi S. Antibacterial nanoparticles on orthodontic materials: A narrative synthesis. Prog Orthod. 2023;24(1):30.
  24. Mollabashi V, Moaddeli MR, Sheikh Al Eslamian SM, Gholami H, Hasanzadeh N, Ghassemi A. Clinical evaluation of TiO2 coated nickel titanium orthodontic archwires on Streptococcus mutans adhesion. Eur J Orthod. 2020;42(4):403–9.
  25. Baby R, Shetty PC, Vinod V, Hegde R, Shetty S, Jagadish P. Photocatalytic TiO2 coated stainless steel orthodontic wires and brackets: Antibacterial and cytotoxic characteristics. Prog Orthod. 2017;18(1):30.
  26. D’Antò V, Valletta R, Amato M, Martina S, Simeon V, Rengo S, et al. Effects of TiO2 and ZnO nanoparticle containing orthodontic bonding agents on enamel white spot lesions. Biointerface Res Appl Chem. 2021;11(3):9598–608.
  27. Mozayeni MA, Namazikhah MS, Nouroozi S, Alimoradi A, Alikhasi M, Samiei M. Effect of various nanoparticle coatings on the frictional properties of orthodontic archwires: A systematic review. BMC Oral Health. 2022;22(1):215.
  28. Farahani A, Pakshir HR, Zomorodian K, Yaghoobi R, Hosseini SM, Aslani H, et al. Use of antimicrobial silver coatings on fixed orthodontic appliances: A systematic review. Materials (Basel). 2024;17(12):4178.
  29. Reddy S, Rao P, Ramesh A, Reddy S, Raju K, Kumar P. Nanoparticle based oral rinses for prevention of white spot lesions in fixed orthodontic treatment: A systematic review. J Clin Diagn Res. 2025;19(9):ZE01–ZE08.
  30. Huang X, Li M, Hu X, Zhang Y, Wang W, Chen J. Quaternary ammonium modified gold nanocluster coated clear aligners for antibacterial effect and esthetics. Front Bioeng Biotechnol. 2020;8:1234.
  31. Alshahrani I, Alqahtani N, Alshahrani A, Almutairi B, Alharbi A, Alshahrani A, et al. Dual mode antibacterial orthodontic composite: Contact killing and drug releasing mesoporous silica nanoparticles. J Mech Behav Biomed Mater. 2025;152:106078.
  32. Park JH, Kim JY, Lee JH, Kim HE, Kim YK, Choi SH. Antibacterial orthodontic adhesives containing AgNPs: A systematic review. Angle Orthod. 2023;93(5):652–60.
  33. Sivaraman K, Elangovan S, Sushma S, Rao A, Shetty S, Nandakumar K. Nanotechnology based approaches for prevention of white spot lesions during orthodontic treatment. Int J Orthod Rehabil. 2022;13(2):85–94.
  34. Alavi S, Jamalpour MR, Farhadian N, Kamali A, Rahimi H, Zarei M. Functional nanoparticles in orthodontics: Focus on biofilm control and enamel protection. J Orthod Sci. 2023;12:40.
  35. Zhao Q, Li H, Liu J, Zhang Y, Chen L, Wang X. Antibacterial photocatalytic coatings on orthodontic brackets: TiO2 based strategies. Coatings. 2021;11(9):1052.
  36. Zhang Y, Li H, Zhao Q, Liu J, Chen L, Wang X. Orthodontic adhesives containing nano hydroxyapatite and silver nanoparticles: Antibacterial activity and enamel remineralization. Materials (Basel). 2024;17(6):2105.
  37. Lin M, Chen Y, Li X, Zhao L, Liu Z, Wang H. Long term antibacterial performance of AgNP coated orthodontic microimplants. Clin Oral Investig. 2023;27(3):1815–25.
  38. Patel P, Shah R, Mehta S, Desai K, Joshi M, Patel K. Cytotoxicity assessment of nanoparticle coated orthodontic brackets and wires: A systematic review. Int Orthod. 2024;22(1):89–101.
  39. Torres F, Garcia M, Lopez R, Sanchez J, Ramirez C, Diaz A. Patient reported outcomes with antibacterial orthodontic appliances: A scoping review. Eur J Paediatr Dent. 2025;26(3):210–8.
  40. Kumar A, Singh P, Gupta N, Verma R, Sharma V, Patel S. Regulatory and translational aspects of nanoparticle modified orthodontic materials. Regul Toxicol Pharmacol. 2024;148:105425.

Regular Issue Subscription Review Article
Volume 17
Issue 02
Received 27/02/2026
Accepted 28/05/2026
Published 24/08/2026
Publication Time 178 Days


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