Biopolymer-Based 3D Composite Scaffolds for Bone Tissue Engineering: Photothermal-Responsive Systems with Controlled Pt (IV) Prodrug Release

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Year : 2026 | Volume : 14 | 03 | Page :
    By

    Pasunuti Durga,

  • C. Hazarathaiah Yadav,

  • Darwin R S,

  • Mahesh Kumar Thota,

  1. Professor and Head, Department of Chemistry, Vel Tech Rangarajan Dr. Sakunthala R&D Institute of science &Technology, Avadi, Chennai, Tamil Nadu, India
  2. Research Scholar, Department of Chemistry, Vel Tech Rangarajan Dr. Sakunthala R&D Institute of science &Technology, Avadi, Chennai, Tamil Nadu, India
  3. Research Scholar, Department of Chemistry, Vel Tech Rangarajan Dr. Sakunthala R&D Institute of science &Technology, Avadi, Chennai, Tamil Nadu, India
  4. Assistant Professor, Department of Computer Science and Engineering, Koneru Lakshmaiah Education Foundation, Bowrampet, Hyderabad, Telangana, India

Abstract

Biopolymer-based composite scaffolds have attracted significant attention as multifunctional platforms at the intersection of polymer science, regenerative medicine, and cancer nanotherapy. In this study, a dual-functional scaffold was developed for simultaneous osteosarcoma treatment and bone regeneration using poly (L-lactic acid) (PLLA) reinforced with bioactive glass (BG) and integrated with a glutathione-responsive platinum (IV) prodrug system (PDA@Pt). To improve interfacial adhesion, photothermal conversion efficiency, and tumor-specific activation, the Pt (IV) prodrug was conjugated onto polydopamine (PDA) nanoparticles. These nanofillers were uniformly embedded within the PLLA/BG matrix via selective laser sintering (SLS), enabling precise architectural control, optimized porosity, and enhanced mechanical stability suitable for load-bearing bone applications.

The engineered scaffold exhibited a highly interconnected porous structure that supported nutrient transport, vascularization, and cell infiltration, while maintaining improved compressive strength due to synergistic reinforcement from bioactive glass and polymer crystallinity. Under near-infrared (NIR) irradiation, the scaffold generated localized hyperthermia, enabling efficient tumor ablation and simultaneously triggering the reduction of Pt (IV) to cytotoxic Pt (II) species in the glutathione-rich tumor microenvironment. The drug release profile showed sustained and stimuli-responsive kinetics governed by matrix degradation and redox-sensitive cleavage mechanisms, ensuring controlled therapeutic delivery.

In vitro studies demonstrated strong cytotoxicity against osteosarcoma cells, along with induction of immunogenic cell death and activation of the cGAS–STING signaling pathway, highlighting its promise for polymer-mediated cancer immunotherapy. Concurrently, the scaffold promoted osteogenic differentiation of bone marrow mesenchymal stem cells, as evidenced by increased alkaline phosphatase activity and osteocalcin expression.

In vivo results further confirmed effective tumor suppression under NIR exposure and accelerated bone regeneration in critical-sized defects with improved tissue integration. Overall, this work highlights the potential of integrating polymer matrices, bioactive inorganic phases, and multifunctional nanocarriers to develop advanced scaffolds with synchronized therapeutic and regenerative functions for regenerative oncology and personalized biomedical applications.

Keywords: Biopolymeric composites, 3D polymer scaffolds, Photothermal-responsive materials, Polymer-based drug delivery systems, Platinum-based prodrugs, Controlled release kinetics, Tissue engineering matrices

How to cite this article:
Pasunuti Durga, C. Hazarathaiah Yadav, Darwin R S, Mahesh Kumar Thota. Biopolymer-Based 3D Composite Scaffolds for Bone Tissue Engineering: Photothermal-Responsive Systems with Controlled Pt (IV) Prodrug Release. Journal of Polymer & Composites. 2026; 14(03):-.
How to cite this URL:
Pasunuti Durga, C. Hazarathaiah Yadav, Darwin R S, Mahesh Kumar Thota. Biopolymer-Based 3D Composite Scaffolds for Bone Tissue Engineering: Photothermal-Responsive Systems with Controlled Pt (IV) Prodrug Release. Journal of Polymer & Composites. 2026; 14(03):-. Available from: https://journals.stmjournals.com/jopc/article=2026/view=244498


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Ahead of Print Subscription Original Research
Volume 14
03
Received 23/04/2026
Accepted 06/05/2026
Published 20/05/2026
Publication Time 27 Days
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