Application of Natural and Synthetic Polymer-Based Disintegrants in the Design of Fast Dissolving Cefuroxime Axetil Tablet Composites

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This is an unedited manuscript accepted for publication and provided as an Article in Press for early access at the author’s request. The article will undergo copyediting, typesetting, and galley proof review before final publication. Please be aware that errors may be identified during production that could affect the content. All legal disclaimers of the journal apply.

Year : 2026 | Volume : 14 | 02 | Page :
    By

    Mallikarjuna BP,

  • G. Swarna Latha,

  • Durga Ganesh Jami,

  • G Uma Rani,

  • Prasanthi Samathoti,

  1. Professor, Department of Pharmaceutical Chemistry, Shridevi Institute of Pharmaceutical Sciences, Tumkur, Karnataka, India
  2. Professor, Department of Pharmaceutical chemistry, Mahathi college of Pharmacy, Annamayya Dist, Andhra Pradesh, India
  3. Ph.D Scholar, Department of Pharmaceutical Sciences, Shri Jagadish Prasad Jhabarmal Tibrewala University, Jhunjhunu, Rajasthan, India
  4. Associate Professor, Department of Pharmaceutics, RBVRR Women’s college of Pharmacy, Barkatpura, Hyderabad, Telangana, India
  5. Associate Professor, Department of Pharmaceutics, Mohan Babu School of pharmaceutical Sciences (Erstwhile Sree vidyanikethan college of pharmacy), MBU, Tirupati, Andhra Pradesh, India

Abstract

The current paper examines how natural and synthetic polymer-based disintegrants can be used to design fast-soluble types of tablet composites. A model drug was chosen and tablets were prepared by the direct compression method using different polymeric excipients, such as guar gum, locust bean gum, sodium starch glycolate (SSG) and cross povidone. Eight formulations were prepared and tested on the basis of critical material and performance characteristics including thickness, hardness, friability, disintegration time, in-vitro drug release, and drug content uniformity.

The findings showed that the use of polymeric super disintegrants had a considerable effect on the composite matrix structure and functional behaviour of the pills. It is notable that locust bean gum, a natural polysaccharide, had similar or better disintegration performance and release performances in comparison with the synthetic polymers, including SSG and cross povidone. This brings out its promise as an environmentally friendly and efficient polymeric excipient in pharmaceutical blends.

In general, the work shows that the performance of the fast-dissolving drug delivery system is determined by the physicochemical interactions of natural and synthetic disintegrant polymers. The results also indicate that biodegradable gums such as locust bean gum can be useful to replace synthetic polymers in the creation of environmentally-friendly and effective composite arrangements.

Keywords: Locust bean gum, Disintegrantion, Fast dissolving tablets, Super disintegrants, antimicrobial efficacy, Natural gums.

How to cite this article:
Mallikarjuna BP, G. Swarna Latha, Durga Ganesh Jami, G Uma Rani, Prasanthi Samathoti. Application of Natural and Synthetic Polymer-Based Disintegrants in the Design of Fast Dissolving Cefuroxime Axetil Tablet Composites. Journal of Polymer & Composites. 2026; 14(02):-.
How to cite this URL:
Mallikarjuna BP, G. Swarna Latha, Durga Ganesh Jami, G Uma Rani, Prasanthi Samathoti. Application of Natural and Synthetic Polymer-Based Disintegrants in the Design of Fast Dissolving Cefuroxime Axetil Tablet Composites. Journal of Polymer & Composites. 2026; 14(02):-. Available from: https://journals.stmjournals.com/jopc/article=2026/view=241459


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Ahead of Print Subscription Original Research
Volume 14
02
Received 19/09/2025
Accepted 13/10/2025
Published 29/04/2026
Publication Time 222 Days
2

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