Metabolic Syndrome in Psoriatic Patients: A Cross-Sectional Study

Year : 2026 | Volume : 15 | Issue : 01 | Page : 17 23
    By

    Mohit Gautam,

  • Seema Sharma,

  • Kusum Bala Jain,

  • Gulab Kanwar,

  • Mukesh Vijayvergia,

  1. PG Resident, Department of Biochemistry, Government Medical College (GMC), Kota, Rajasthan, India
  2. Assistant Professor, Department of Microbiology, Government Medical College (GMC), Bundi, Rajasthan, India
  3. Associate Professor, Department of Biochemistry, Government Medical College (GMC), Kota, Rajasthan, India
  4. Senior Professor & Head, Department of Biochemistry, Government Medical College (GMC), Kota, Rajasthan, India
  5. Joint Director (Disaster Management), Directorate of Medical & Health Services, Department of Medical, Health & Family Welfare, Government of Rajasthan, Jaipur, Rajasthan, India

Abstract

Background: Psoriasis is a chronic immuno-inflammatory disease affecting the skin and joints. Studies have demonstrated an increased prevalence of conventional cardiovascular risk factors such as diabetes mellitus, hypertension, and metabolic syndrome in these patients. The aim of this study was to determine the association between psoriasis and metabolic syndrome. Material and Method: An observational cross-sectional study was carried out between November 2023 and October 2024, including participants with and without psoriasis. Blood samples were analysed for serum lipid profile and fasting blood sugar to assess biochemical variations. Clinical Examination done to evaluate blood pressure and waist circumference (for central obesity). Result: 100 participants, 50 with psoriasis and 50 healthy controls were recruited. The prevalence of metabolic syndrome in psoriatic patient was observed 24% in comparison to control 16% (p < 0.05). Conclusion: Patients with psoriasis have a higher prevalence of metabolic syndrome compared to the general population. Therefore, identification of metabolic syndrome can be done routinely for better management of psoriasis.

Keywords: Cardiovascular risk factors, dyslipidemia, inflammatory mediators, insulin resistance, metabolic syndrome, psoriasis

[This article belongs to Research and Reviews : A Journal of Medical Science and Technology ]

How to cite this article:
Mohit Gautam, Seema Sharma, Kusum Bala Jain, Gulab Kanwar, Mukesh Vijayvergia. Metabolic Syndrome in Psoriatic Patients: A Cross-Sectional Study. Research and Reviews : A Journal of Medical Science and Technology. 2026; 15(01):17-23.
How to cite this URL:
Mohit Gautam, Seema Sharma, Kusum Bala Jain, Gulab Kanwar, Mukesh Vijayvergia. Metabolic Syndrome in Psoriatic Patients: A Cross-Sectional Study. Research and Reviews : A Journal of Medical Science and Technology. 2026; 15(01):17-23. Available from: https://journals.stmjournals.com/rrjomst/article=2026/view=239570


References

  1. Dogra S, Yadav S. Psoriasis in India: Prevalence and pattern. Indian J Dermatol Venereol Leprol. 2010;76(6):595–601.
  2. Kaur I, Kumar B, Sharma VK, Kaur S. Epidemiology of psoriasis in a clinic from North India. Indian J Dermatol Venereol Leprol. 1986;52(4):208–212.
  3. Bedi TR. Psoriasis in North India. Dermatologica. 1977;155(5):310–314.
  4. Rakhesh SV, D’Souza M, Sahai A. Quality of life in psoriasis: A study from South India. Indian J Dermatol Venereol Leprol. 2008;74(6):600–606.
  5. Madanagobalane S, Anandan S. Prevalence of metabolic syndrome in South Indian patients with psoriasis vulgaris and relation between disease severity and metabolic syndrome: A hospital-based case-control study. Indian J Dermatol. 2012;57(5):353–357.
  6. Cornier MA, Dabelea D, Hernandez TL, Lindstrom RC, Steig AJ, Stob NR, et al. The metabolic syndrome. Endocr Rev. 2008;29(7):777–822.
  7. Nisa N, Qazi M. Prevalence of metabolic syndrome in patients with psoriasis. Indian J Dermatol Venereol Leprol. 2010;76(6):662–665.
  8. Armstrong AW, Harskamp CT, Armstrong EJ. Psoriasis and the risk of diabetes mellitus: A systematic review and meta-analysis. JAMA Dermatol. 2013;149(1):84–91.
  9. Allen MH, Ameen H, Veal C, Evans J, Ramrakha-Jones VS, Marsland AM, et al. The major psoriasis susceptibility locus PSORS1 is not a risk factor for late-onset psoriasis. J Invest Dermatol. 2005;124(1):103–106.
  10. Zindanci I, Albayrak O, Kavala M, Kocaturk E, Can B, Sudogan S, et al. Prevalence of metabolic syndrome in patients with psoriasis. Sci World J. 2012;2012:1–5.
  11. Gelfand JM, Dommasch ED, Shin DB, Azfar RS, Kurd SK, Wang X, et al. The risk of stroke in patients with psoriasis. J Invest Dermatol. 2009;129(10):2411–2418.
  12. Naldi L, Peli L, Parazzini F, Carrel CF. Family history of psoriasis, stressful life events, and recent infectious disease are risk factors for a first episode of acute guttate psoriasis: Results of a case-control study. J Am Acad Dermatol. 2001;44(3):433–438.
  13. Kim GW, Park HJ, Kim HS, Kim SH, Ko HC, Kim BS, et al. Analysis of cardiovascular risk factors and metabolic syndrome in Korean patients with psoriasis. Ann Dermatol. 2012;24(1):11–15.
  14. Lakshmi S, Srinivas CR, Mathew AC, et al. Metabolic syndrome in patients with psoriasis: A comparative study. Indian Dermatol Online J. 2014;5(2):132–137.
  15. Cohen AD, Dreiher J, Shapiro Y, Vidavsky L, Vardy DA, Davidovici B, et al. Psoriasis and diabetes: A population-based cross-sectional study. J Eur Acad Dermatol Venereol. 2008;22(5):585–589.
  16. Abel EA, DiCicco LM, Orenberg EK, Fraki JE, Farber EM. Drugs in exacerbation of psoriasis. J Am Acad Dermatol. 1986;15(5 Pt 1):1007–1022.
Regular Issue Subscription Review Article
Volume 15
Issue 01
Received 29/11/2025
Accepted 05/02/2026
Published 10/03/2026
Publication Time 101 Days
13

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