Solubility Enhancement of Verapamil Using the Solid Dispersion Method

Year : 2026 | Volume : 17 | 01 | Page :
    By

    Ashwini Jadhav,

  • Prajwal Cheulkar,

  • Harsh Gore,

  • Prasad Magare,

  • Neha Gupta,

  • Kiran Bhosale,

  • Tushar Shelke,

  1. Assistant Professor, Department of Pharmacy, Genba Sopanrao Moze College of Pharmacy, Wagholi Pune, Maharashtra, India
  2. Research Scholar, Department of Pharmacy, Genba Sopanrao Moze College of Pharmacy, Wagholi Pune, Maharashtra, India
  3. Research Scholar, Department of Pharmacy, Genba Sopanrao Moze College of Pharmacy, Wagholi Pune, Maharashtra, India
  4. Research Scholar, Department of Pharmacy, Genba Sopanrao Moze College of Pharmacy, Wagholi Pune, Maharashtra, India
  5. Assistant Professor, Department of Pharmacy, Genba Sopanrao Moze College of Pharmacy, Wagholi Pune, Maharashtra, India
  6. Assistant Professor, Department of Pharmacy, Genba Sopanrao Moze College of Pharmacy, Wagholi Pune, Maharashtra, India
  7. Assistant Professor, Department of Pharmacy, Genba Sopanrao Moze College of Pharmacy, Wagholi Pune, Maharashtra, India

Abstract

By creating a solid dispersion, this study aimed to address the limitations of the traditional solid dosage form of verapamil, including its low bioavailability and restricted clinical efficacy. In order to alter the drug’s release and improve its solubility, verapamil solid dispersion was created using the Solvent Evaporation Method and Fusion Method. The physical state of the solid dispersed verapamil was determined using saturation solubility testing and dissolution studies. Verapamil Solid Dispersions Prepared using the Fusion Method (Drug to PEG-4000:1:2) results in maximum drug release as compared to pure drug, and the dissolution of verapamil solid dispersion is significantly improved. The current study showed that the employment of water-soluble carriers in a variety of solid dispersion techniques increased the solubility of weakly water-soluble medicines significantly.

Keywords: Solubility, Bioavailability, Solid Dispersion, Dissolution, Solvent Evaporation.

How to cite this article:
Ashwini Jadhav, Prajwal Cheulkar, Harsh Gore, Prasad Magare, Neha Gupta, Kiran Bhosale, Tushar Shelke. Solubility Enhancement of Verapamil Using the Solid Dispersion Method. Research and Reviews: A Journal of Pharmaceutical Science. 2025; 17(01):-.
How to cite this URL:
Ashwini Jadhav, Prajwal Cheulkar, Harsh Gore, Prasad Magare, Neha Gupta, Kiran Bhosale, Tushar Shelke. Solubility Enhancement of Verapamil Using the Solid Dispersion Method. Research and Reviews: A Journal of Pharmaceutical Science. 2025; 17(01):-. Available from: https://journals.stmjournals.com/rrjops/article=2025/view=233210


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Ahead of Print Subscription Original Research
Volume 17
01
Received 30/09/2025
Accepted 23/11/2025
Published 27/11/2025
Publication Time 58 Days
177

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