Jennifer S,
Mehak Khanum,
Ehsan Mohebi,
Zaid Khan,
- B. Pharm, Research Scholar, Department of Pharmaceutics, Faculty of Pharmacy, St. Jhon’s Pharmacy College, Bangalore 560104, Karnataka, India
 - B. Pharm, Research Scholar, Department of Pharmaceutics, Faculty of Pharmacy, St. Jhon’s Pharmacy College, Bangalore 560104, Karnataka, India
 - Pharm D., Intern, Research Scholar, Department of Pharmacy Practice, Faculty of Pharmacy, Aditya Bangalore Institute of Pharmacy Education and Research, Bangalore, Karnataka, India
 - Pharm D., Intern, Research Scholar, Department of Pharmacy Practice, Faculty of Pharmacy, Aditya Bangalore Institute of Pharmacy Education and Research, Bangalore, Karnataka, India
 
Abstract
Membrane technology has emerged as a cornerstone in the advancement of artificial organ systems, offering critical functionalities in selective molecular filtration, tissue scaffolding, and controlled therapeutic delivery. Recent innovations have propelled the field beyond traditional polymeric membranes to include nanostructured, biomimetic, and stimuli-responsive materials, significantly enhancing biocompatibility, selectivity, and durability. The integration of smart technologies, such as AI-driven membrane design, bioelectronic sensors, and personalized fabrication via 3D printing, is ushering in a new era of intelligent, adaptive, and patient-specific artificial organs. Despite these achievements, significant challenges remain, including membrane fouling, long-term degradation, immune responses, regulatory hurdles, and economic barriers to widespread adoption particularly in low-resource settings. Interdisciplinary collaboration among materials scientists, engineers, clinicians, and data scientists is increasingly vital for translating laboratory advances into clinically viable solutions. Sustainable and scalable manufacturing approaches, coupled with a focus on global health equity, are essential to ensuring that next-generation membrane-based artificial organs are accessible to diverse patient populations. Looking forward, the field is poised for transformative growth, with milestones anticipated in AI-guided design, eco-friendly materials, wearable organ support devices, and equitable distribution models. This review provides a comprehensive overview of current technologies, addresses prevailing challenges, and proposes a strategic roadmap for the continued evolution of membrane technology in artificial organs, with the goal of improving patient outcomes and addressing global healthcare needs.
Keywords: Artificial organs, membrane technology, hemodialysis membranes, biomimetic membranes, nanostructured membranes, drug delivery systems, tissue engineering, bioartificial organs, biocompatibility, smart membranes, AI-driven membrane design, 3D printing, bioelectronics, personalized medicine, sustainable membranes, scalable manufacturing, global health, wearable dialysis, regulatory challenges, interdisciplinary collaboration
[This article belongs to International Journal of Membranes ]
Jennifer S, Mehak Khanum, Ehsan Mohebi, Zaid Khan. Revolutionizing Artificial Organs: Next-Generation Membrane Technologies for Precision Medicine and Global Health. International Journal of Membranes. 2025; 02(02):1-11.
Jennifer S, Mehak Khanum, Ehsan Mohebi, Zaid Khan. Revolutionizing Artificial Organs: Next-Generation Membrane Technologies for Precision Medicine and Global Health. International Journal of Membranes. 2025; 02(02):1-11. Available from: https://journals.stmjournals.com/ijm/article=2025/view=229154
References
- Ronco C, Clark WR. Artificial organs: The role of membranes in hemodialysis and bioartificial devices. Kidney Int Suppl. 2018;8(2):123–30.
 - Nunes SP, Peinemann KV. Membranes for artificial organs and tissue engineering. Adv Mater. 2017;29(10):1605449.
 - Zydney AL. Membrane technology in artificial organs: Past, present, and future. J Membr Sci. 2019;587:117183.
 - Li J, Mooney DJ. Designing hydrogels for controlled drug delivery. Nat Rev Mater. 2016;1(12):16071.
 - Zhang YS, Khademhosseini A. Advances in engineering hydrogels. Science. 2017;356(6337):eaaf3627.
 - Lee J, Kim J, Park S, et al. Smart membranes for biomedical applications: A review. Biomaterials. 2020;230:119619.
 - Wang Y, Liu X, Zhang P, et al. Personalized membrane design for hemodialysis: Challenges and opportunities. ACS Biomater Sci Eng. 2021;7(3):1032–44.
 - Humes HD, Fissell WH. Bioartificial organs: Bridging the gap between organ failure and transplantation. Clin J Am Soc Nephrol. 2019;14(9):1355–63.
 - Ronco C, Clark WR. Haemodialysis membranes. Nat Rev Nephrol. 2018;14(6):394–410.
 - Ward RA. Membrane science and technology in hemodialysis: Current status and future directions. J Membr Sci. 2021;634:119434.
 - Ferreira AM, Gentile P, Chiono V, Ciardelli G. Collagen for bone tissue regeneration. Acta Biomater. 2012;8(9):3191–200.
 - Yamashita AC. History and recent progress of hemodialysis membranes. Contrib Nephrol. 2011;173:1–10.
 - Wang X, Ding B, Li B. Biomimetic nanofibrous membranes: From material design to biomedical applications. Adv Mater. 2013;25(43):5336–55.
 - Liu Y, Yang J, Zhan X, et al. Computational modeling in membrane design: From molecular to process scale. J Membr Sci. 2020;598:117681.
 - Lee Y, Chen H, Sun J, et al. Nanocomposite membranes for enhanced hemodialysis performance. J Membr Sci. 2022;659:120792.
 - Zhao Y, Lin T, Wang H, et al. Antibacterial nanocomposite membranes for dialysis. ACS Appl Mater Interfaces. 2021;13(8):9423–34.
 - Zhang M, Li Y, Zhou J, et al. Carbon nanomaterials in advanced hemodialysis membranes. Adv Funct Mater. 2020;30(17):1907087.
 - Liu Y, Zhao H, Xu J, et al. Surface-modified hemodialysis membranes with zwitterionic polymers. Biomaterials. 2021;268:120561.
 - Wang J, Chen Q, Huang Z, et al. Hemocompatibility of peptide-functionalized membranes. Colloids Surf B Biointerfaces. 2023;210:112264.
 - Liu Y, Chen X, Huang J, et al. Biomimetic membrane designs for renal replacement therapy. Adv Healthc Mater. 2020;9(1):1901189.
 - Ouseph R, Patel K, Sharma V, et al. High-flux membranes and patient outcomes: A meta-analysis. Am J Kidney Dis. 2022;80(2):191–201.
 - Patel M, Singh R, Thomas A, et al. Advanced dialysis membranes reduce cardiovascular risk. Clin J Am Soc Nephrol. 2021;16(10):1472–81.
 - Humes HD, Weitzel WF, Fissell WH, et al. The bioartificial kidney: Current status and future promise. Pediatr Nephrol. 2022;37(8):1791–802.
 - Zhang YS, Yue K, Aleman J, et al. 3D bioprinting for tissue and organ fabrication. Ann Biomed Eng. 2021;49(1):5–22.
 - Kim BS, Das S, Jang J, et al. Decellularized extracellular matrix-based bioinks for engineering tissue- and organ-specific microenvironments. Chem Rev. 2020;120(19):10608–61.
 - Orlando G, Wood KJ, Stratta RJ, et al. Regenerative medicine and organ transplantation: Past, present, and future. Transplantation. 2021;105(3):e41–55.
 - Song JJ, Ott HC. Organ engineering based on decellularized matrix scaffolds. Trends Mol Med. 2021;27(7):676–90.
 - Finesilver HR, Leigh NJ, Tandon P, et al. Vascularization strategies in tissue engineering: Recent advances and regulatory considerations. Tissue Eng Part B Rev. 2023;29(2):193–210.
 - Milluzzo A, Spadaccio C, Nappi F, et al. Hybrid synthetic-natural scaffolds for tissue engineering: Current advances and future perspectives. Int J Artif Organs. 2022;45(6):441–52.
 - Mazzeo L. Drug delivery with membranes systems. In: Membrane-based technologies for drug delivery. 2019.
 - Sheng Y, Hu J, Shi J, Lee LJ. Stimuli-responsive carriers for controlled intracellular drug release. Curr Med Chem. 2019;26(13):2377–88. doi:10.2174/0929867324666170830102409.
 - Hu CMJ, Zhang L, Aryal S, Cheung C, Fang RH, Zhang L. Coating nanoparticles with cell membranes for targeted drug delivery. Adv Mater. 2015;27(23):3529–40.
 - Yu M, Chen Z, Wang J, et al. Predicting drug release kinetics from nanocarriers inside dialysis membranes. Int J Pharm. 2019;564:1–10.
 - Makhaik P. A potential approach of scaffolds for drug delivery in tissue engineering. Pharma J. 2012;2(10):1–6.
 - Koria P. Delivery of growth factors for tissue regeneration and wound healing. BioDrugs. 2012;26(3):163–75. doi:10.2165/11631850-000000000-00000.
 - Madaeni SS. The application of membrane technology for water disinfection. Water Res. 1999;33(10):2337–48.
 - Flemming HC, Wingender J. The biofilm matrix. Nat Rev Microbiol. 2010;8(9):623–33.
 - Zhang YS, Arneri A, Bersini S, et al. 3D bioprinting for tissue and organ fabrication. Ann Biomed Eng. 2017;45(1):148–63.
 - Liu X, Zhao Y, Wang Y, et al. Nanostructured membranes for artificial organs: Fabrication and challenges. Adv Mater. 2020;32(15):1905117.
 - Geise GM, Lee H, Miller DJ, Freeman BD, McGrath JE, Paul DR. Water purification by membranes: The role of polymer science. J Polym Sci B Polym Phys. 2014;52(3):168–79.
 
- Anderson JM, Rodriguez A, Chang DT. Foreign body reaction to biomaterials. Semin Immunol. 2008;20(2):86–100.
 - S. Food and Drug Administration. Medical device regulation: Overview. Silver Spring (MD): FDA; 2023 [cited 2025 Aug 26]. Available from: https://www.fda.gov
 - Li X, Sun J, Zhao H, et al. Long-term performance of polymeric membranes in bioartificial organs: A review. J Membr Sci. 2021;618:118703.
 - Daniels R, Kumar P, Singh A, et al. Cost-effectiveness of advanced membrane technologies in healthcare. Health Econ Rev. 2022;12(1):45.
 - Emanuel EJ, Grady C, Wendler D, et al. Ethical considerations in the development and deployment of bioartificial organs. Am J Bioeth. 2019;19(7):4–15.
 - Shinde SS, Patil A, Kulkarni A, et al. Machine learning for membrane design: A review. J Membr Sci. 2023;654:120566.
 - Lee JH, Park S, Kim H, et al. AI-enabled optimization of nanoporous membranes for selective separation. Adv Mater. 2024;36(5):2107890.
 - Chen Q, Lin Y, Zhou Z, et al. Biomimetic membranes: From natural extracellular matrix to synthetic analogs. Biomaterials. 2022;284:121456.
 - Zhang Y, Li J, Wang X, et al. Advances in ECM-mimicking membranes for tissue engineering applications. Acta Biomater. 2023;157:1–15.
 - Park S, Kim H, Lee J, et al. Bioelectronic membranes for real-time monitoring of filtration performance. Nat Commun. 2023;14:1234.
 - Kumar A, Sharma P, Gupta R, et al. Interdisciplinary approaches in membrane technology development. Mater Today. 2022;55:45–59.
 - Singh R, Patel K, Zhao Y, et al. Computational modeling for membrane design: Finite element and molecular dynamics perspectives. Comput Mater Sci. 2023;212:111456.
 - Wang L, Zhou H, Chen Y, et al. 3D printing of patient-specific membranes for personalized medicine. Adv Healthc Mater. 2024;13(2):2300456.
 - Patel M, Singh A, Verma S, et al. Tailored drug delivery systems based on metabolic profiling. J Control Release. 2023;354:314–28.
 - Silva F, Almeida P, Costa M, et al. Sustainable membrane materials: Trends and challenges. J Clean Prod. 2023;389:135857.
 - Chen H, Xu J, Lin Z, et al. Additive manufacturing for scalable membrane fabrication. ACS Appl Mater Interfaces. 2024;16(10):12345–58.
 - Garcia-Gonzalez D, Torres P, Ramirez J, et al. Portable dialysis devices: Membrane innovations and clinical potential. Kidney Int. 2023;103(3):456–69.
 - Mensah S, Boateng J, Asare P, et al. Bioartificial organs for global health: Challenges and opportunities. Front Bioeng Biotechnol. 2024;12:987654.
 

International Journal of Membranes
| Volume | 02 | 
| Issue | 02 | 
| Received | 07/07/2025 | 
| Accepted | 14/08/2025 | 
| Published | 18/08/2025 | 
| Publication Time | 42 Days | 
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