Polymer Chemistry-Guided Development of Biomimetic Composite Scaffolds

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Year : 2025 | Volume : 13 | 05 | Page :
    By

    Pratik Prakash Somade,

  • Atul R Chopade,

  • Mangesh A. Bhutkar,

  1. , Krishna Institute of Medical Sciences, Krishna Vishwa Vidyapeeth (Deemed to be University), Karad-415539, Maharashtra, India
  2. , Rajarambapu College of Pharmacy, Kasegaon, Taluka – Walwa, Sangli, Maharashtra 415409 Krishna Vishwa Vidyapeeth (Deemed to be University), Karad-415539, Maharashtra, India
  3. , Rajarambapu College of Pharmacy, Kasegaon, Taluka – Walwa, Sangli, Maharashtra, India

Abstract

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Polymer chemistry is essentially playing an important part in advancing biomaterials for anatomical tissue engineering, particularly in the design of composite scaffolds that imitate characteristics of tissues. The regeneration of damaged tissues, particularly in anatomically complex structures like bone, cartilage, and skin, necessitates biomaterials that closely emulate the architecture and biological functions of native extracellular matrices (ECMs). The capability to replicate both mechanical and biochemical cues of the natural ECM has made these scaffolds central to current strategies in regenerative medicine and pharmaceutical technology.  This review presents a comprehensive examination of polymer-based composites, focusing on innovations from 2020 to 2025. It begins by categorizing polymers into synthetic, natural, and hybrid types and discusses composite design principles such as matrix–filler interactions, crosslinking, and surface functionalization. The review emphasizes structure–property relationships and their relevance in mimicking human tissues. The anatomical relevance of mechanical properties and scaffold geometry is discussed for both load-bearing and soft tissues. Future directions highlight multi-scale modeling for personalized scaffold design, the emergence of sustainable and green polymers, and the potential of 4D printing for adaptive, patient-specific systems. By integrating recent research trends, this review provides a foundational understanding of how polymer chemistry continues to shape the future of functional and anatomically-relevant biomaterials in regenerative medicine.

Keywords: Polymer composites; Biomimetic scaffolds; Tissue engineering; Anatomical modeling; 3D printing; 4D printing; Functional polymers; Regenerative medicine; Green biomaterials.

How to cite this article:
Pratik Prakash Somade, Atul R Chopade, Mangesh A. Bhutkar. Polymer Chemistry-Guided Development of Biomimetic Composite Scaffolds. Journal of Polymer and Composites. 2025; 13(05):-.
How to cite this URL:
Pratik Prakash Somade, Atul R Chopade, Mangesh A. Bhutkar. Polymer Chemistry-Guided Development of Biomimetic Composite Scaffolds. Journal of Polymer and Composites. 2025; 13(05):-. Available from: https://journals.stmjournals.com/jopc/article=2025/view=0


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Ahead of Print Subscription Review Article
Volume 13
05
Received 13/05/2025
Accepted 06/06/2025
Published 21/08/2025
Publication Time 100 Days
100

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