Swift Solutions: The Science and Innovation Behind Fast-Dissolving Tablets

Year : 2025 | Volume : 16 | Issue : 03 | Page :
    By

    Sachin Someshwar,

  • Akanksha Dwivedi,

  • G.N. Darwhekar,

  1. Student, Department of Pharmaceutics, Acropolis Institute of Pharmaceutical Education and Research, Indore, Madhya Pradesh, India
  2. Associate Professor, Department of Pharmaceutics, Acropolis Institute of Pharmaceutical Education and Research, Indore, Madhya Pradesh, India
  3. Principal, Department of Pharmacy, Acropolis Institute of Pharmaceutical Education and Research, Indore, Madhya Pradesh, India

Abstract

document.addEventListener(‘DOMContentLoaded’,function(){frmFrontForm.scrollToID(‘frm_container_abs_200214’);});Edit Abstract & Keyword

Swift solutions in the context of fast dissolving tablets (FDTs) represent an innovative breakthrough in pharmaceutical science, aiming to provide rapid and effective drug delivery for patients who face difficulty swallowing conventional dosage forms. The science and innovation behind FDTs are rooted in advanced formulation techniques, material science, and drug delivery mechanisms that prioritize speed, convenience, and patient compliance. These tablets are formulated to dissolve quickly in the mouth, removing the necessity for water and providing a quicker onset of effects. The development of FDTs relies heavily on the use of cutting-edge technologies, including the incorporation of super disintegrants, water-soluble excipients, and porous materials that facilitate immediate disintegration upon contact with saliva. Techniques such as lyophilization, spray drying, and direct compression are employed to create tablets that dissolve swiftly while maintaining mechanical strength and stability. Additionally, advancements in nanotechnology and polymer science have further enhanced the solubility and bioavailability of poorly water-soluble drugs, enabling faster absorption and improving therapeutic efficacy. Innovations in taste-masking are crucial for enhancing patient adherence, particularly among paediatric and geriatric groups. Furthermore, the integration of effervescent agents and other dissolution-enhancing systems has expanded the possibilities of FDTs, making them suitable for a wide range of therapeutic applications, including acute conditions that require rapid intervention. In conclusion, the science and innovation behind fast dissolving tablets exemplify the growing trend toward patient-centered, rapid drug delivery systems. These swift solutions not only address the clinical challenges of traditional oral dosage forms but also provide enhanced convenience and efficacy, reshaping the future of pharmaceutical development and drug delivery systems.

Keywords: Fast dissolving tablets (FDTs), Super disintegrants, drug delivery system, patented technologies, taste masking.

[This article belongs to Research and Reviews: A Journal of Pharmaceutical Science ]

How to cite this article:
Sachin Someshwar, Akanksha Dwivedi, G.N. Darwhekar. Swift Solutions: The Science and Innovation Behind Fast-Dissolving Tablets. Research and Reviews: A Journal of Pharmaceutical Science. 2025; 16(03):-.
How to cite this URL:
Sachin Someshwar, Akanksha Dwivedi, G.N. Darwhekar. Swift Solutions: The Science and Innovation Behind Fast-Dissolving Tablets. Research and Reviews: A Journal of Pharmaceutical Science. 2025; 16(03):-. Available from: https://journals.stmjournals.com/rrjops/article=2025/view=0


document.addEventListener(‘DOMContentLoaded’,function(){frmFrontForm.scrollToID(‘frm_container_ref_200214’);});Edit

References

[1]. Cheng R, Guo X, Burusid B, Couch R.A review of fast dissolving tablets. Pharm Tech, (North America). June, 2000; 52-58.

[2]. Bi Y, Sunada H, Yonezawa Y, Dayo K, Otsuka A, Iida K. Preparation and evaluation of compressed tablet rapidly disintegrating in oral cavity. Chem Pharm Bull (Tokyo)1996; 44:2121-2127.

[3]. Quick dissolving tablets. http:/www.biospace.com. 27 may, 2001.

[4]. Fu Y, Yang S, Jeong SH, Kimura S, Park K. Orally fast disintegrating tablets: Developments, technologies, taste-masking and clinical studies. Crit Rev Ther Drug Carrier Sys 2004; 21:433-76.

[5]. Suresh Bandari, Rajendar kumar Mitta palli, Ramesh Gannu, Yamsani Madhusudan Rao. Orodispersible tablets: An overview. Asian Journal of pharmaceutics. Jan 2008.

[6]. K. Kavitha, Bhavani Devi V, Yean LK et al. Concepts and salient features of orodispersible drug delivery systems –A Review. International Research Journal of Pharmaceutical and Applied Science 2013; 3(5): 249-252.

[7]. Mehrotra G, Kumar S, Sharma R. Fast dissolving tablet: An overview. International Journal of Research in Pharmaceutical and Biomedical Sciences 2012; 3(3): 1206-1210.

[8]. Siddiqui MDN, Garg G, Sharma PK. Fast dissolving tablets: preparation, characterization and evaluation: an overview. International Journal of Pharmaceutical Sciences Review and Research 2010; 4(2): 87-96.

[9]. D Bhowmik et al., Fast Dissolving Tablet: An Overview, J.Chemical, and Pharma.Research, 2009; 1(1): 163-17

[10]. Mehta Kuldeep, Garala Kevin, Basu Biswajit, Bhalodia Ravi, Joshi Bhavik, Narayana R. An Emerging Trend in Oral Drug Delivery Technology: Rapid Disintegrating Tablets. Journal of Pharmaceutical Science and Technology 2010; 2(10): 318-329

[11]. Habib W, Khankari RK, Hontz J. Fast-dissolve drug delivery systems. Crit Rev Ther Drug Carrier Sys 2000; 17:61-72.

[12]. Van Scoik KG. Solid Pharmaceutical dosage in tablet triturates form and method of producing the same. US Patent 5,082, 667

[13]. Badgujar BP, Mundada AS. The Technologies Used for Developing Orally Disintegrating Tablets: A review. Acta Pharma. 2011; 61(2): 117- 139.

[14] Bircan Y, Comoglu T. Formulation Technologies of Orally Fast Disintegrating Tablets. Marmara Pharm J. 2012; 16(1): 77-81.

[15]. Chowdary YA, Soumya M, Madhu BM. A Review on Fast Dissolving Drug Delivery System- A Pioneering Drug Delivery Technology. BullEnv Pharmacol Life Sci. 2012; 1(12): 8-12.

[16]. Kumar GD, Maurya A. Orodispersible Tablets: An Overview of Formulation and Technology. World J Pharm and Pharm Sci. 2020; 9(10): 1406- 1418.

[17]. Ford J. The current status of solid dispersion. Pharmaceutica Acta Helvetiae 1986; 61:69– 88.

[18]. Dobetti L. Fast melting tablets: Developments and technologies. Pharm Technol Drug Deliv 2001 ;(Suppl):44–50.

[19]. C Kumaresan. Orally Disintegrating Tablet – Mouth dissolving, Sweet Taste, and Target Release Profile; Pharmaceutical review 2008; 6(5):1–10.

[20]. Bhowmik Debjit, Chiranjib B, Kant Krishna, Pankaj, Margret Chandira R. Fast Dissolving Tablet: An Overview. Journal of Chemical and Pharmaceutical Research 2009; 1(1): 163-177.

[21]. Sahoo Susijit, Mishra B, Biswal PK, Panda Omprakash, Mahapatra Santosh Kumar, Jana Goutam Kumar. Fast Dissolving Tablet: As A Potential Drug Delivery System. Drug Invention Today 2010; 2(2): 130-133.

[22]. Yourong Fu, Yang Shichang, Jeong Seong Hoon, Kimura Susumu, Park Kinam. Orally Fast DisintegratingTablets: Developments, Technologies, Taste-Masking and Clinical Studies. Critical Reviews in Therapeutic Drug Carrier Systems 2004; 21(6):433–475.

[23]. .Nand P, Vashist N, Anand A, Drabu Sushma. Mouth Dissolving Tablets- A Novel Drug Delivery System. International Journal of Applied Biology and Pharmaceutical Technology 2010; 1(3):20

[24]. Pawar PB, Mansuk AG, Ramteke KH, Sharma YP, Patil SN. Mouth dissolving tablet: A review. International Journal on Herbal Drug Research 2011; 22-29.

[25]. Sharma S. New Generation of Tablet: Fast Dissolving Tablet. Latest Reviews. Pharmainfo.Net 2008; 6(1).

[26]. Kumari S, Visht S, Sharma PK, Yadav RK. Fast dissolving Drug delivery system: Review Article. Journal of Pharmacy Research 2010; 3(6): 1444-1449. 45

[27]. Kumaresan C. Orally Disintegrating Tablet – Mouth dissolving, Sweet Taste and Target Release Profile. Pharmaceutical review 2008; 6.

[28]. Johnson JR, Wang LH, Gordon MS, Chowhan ZT. Effect of formulation solubility and hygroscopicity on disintegrating efficiency in tablets prepared by wet granulation. Journal of Pharmaceutical Sciences 1991; 80:469–71.

[29]. Billany MR, Aulton ME. Pharmaceutics; The science of Dosage form Design, New York: Churchill Livingstone, International Edition, 1996; p 263.

[30]. Catania JS, Johnson AD. U. S. Patent 5633006. 1997.

[31]. Nelson SL. U.S. Patent 5766622.1998.

[32].  Eby III, Georage A. U.S. Patent 5002970. 1991.

[33].  Pandya HB, Callan TP. U.S. Patent 5, 837, 286. 1998.

[34]. Patel S Taher, Sengupta Mukul. Fast Dissolving Tablet Technology – A Review. World Journal of Pharmacy and Pharmaceutical Sciences 2013; 2 (2): 485-508.

[35]. Bi Y, Sunada H, Yonezawa Y, Danjo K, Otsuka A, Iida K. Preparation and evaluation of a compressed tablet rapidly disintegrating in the oral cavity. Chemical and pharmaceutical bulletin. 1996;44(11):2121-7.

[36]. Gupta AK, Mittal A, Jha KK. Fast dissolving tablet-A review. The pharma innovation. 2012;1(1):1-8.

[37]. Ahmed IS, Nafadi MM, Fatahalla FA. Formulation of a fast-dissolving ketoprofen tablet using freeze-drying in blisters technique. Drug development and industrial pharmacy. 2006;32(4):437-42.

[38]. Anjali T, Kumar PP, Nandyala S, Venkatalakshmi V, Virginia D, Krishna BT, Durga PT, Sowmya DL, Durga S. FAST DISINTEGRATING TABLETS-A REVIEW.2023.

[39]. Bera A, Mukherjee A. A detailed study of mouth dissolving drug delivery system. Acta Chim. Pharm. Indica. 2013;3(1):65-93.

[40]. Kumar S, Garg SK. Fast dissolving tablets (FDTs): Current status, new market opportunities, recent advances in manufacturing technologies and future prospects. Int J Pharm Pharm Sci. 2014;6(7):22-35

[41]. Mishra US, Prajapati SK, Bhardwaj P. A review on formulation and evaluation for mouth dissolving tablet. World J Pharm Pharm Sci. 2014 Jun 5;8:1778-810.

[42]. Pabari RM, McDermott C, Barlow J, Ramtoola Z. Stability of an alternative extemporaneous captopril fast-dispersing tablet formulation versus an extemporaneous oral liquid formulation. Clinical therapeutics. 2012 Nov 1;34(11):2221-9.

[43]. Chang R, Guo X, Burnside B.A., B.A.Couch R.A. AR.A.iew of Fast Dissolving Tablets. PharmTech, 2000; 24(6): 52-58.

[44]. Ohta M., Hayakawa E., Ito K., Tokuno S., Morimoto K., Watanabe V. W.O. Patent 9, 747,287. 1997.

[45]. Yourong F., Shicheng Y, Seong HJ, Kimura S, Park K, Orally Fast Disintegrating Tablets: Developments, Technologies, Taste-Masking and Clinical Studies Critical Reviews in Therapeutic Drug Carrier Systems 2004; 21:6: 433–475.

[46]. Yadav G, Kapoor A, Bhargava S. Fast dissolving tablets recent advantages: A review. International Journal of Pharma Sciences and Research 2012; 3(3): 728 -736.

[47]. Mehta K, Garala K, Basu B, Bhalodia R, Joshi B, Charyulu RN. An emerging trend in oral drug delivery technology: Rapid disintegrating tablets 2010; 2(10): 318-329.

[48]. Patel SS, Patel MS, Patel NM. Flowability testing of directly compressible excipients according to british pharmacopoeia. Journal of Pharmaceutical Research 2009; 8: 66 -69.

[49]. Javier OM, Hong M, Aubey MG, Jason TM. Orally Disintegrating Tablets using starch and fructose. Pharmaceutical Technology 2010: 92-99.

[50]. Sharma D, Kumar D, Singh M, Singh G, Rathore MS. Fast disintegrating tablets: a new era in novel drug delivery system and new market opportunities. Journal of Drug Delivery & Therapeutics 2012; 2(3): 74-86.

[51]. Deshmukh VN. Mouth Dissolving Drug Delivery System: A Review. International Journal of Pharm Tech Research 2012; 4(1): 412-421.

[52]. Patel S Taher, Sengupta Mukul. Fast Dissolving Tablet Technology – A Review. World Journal of Pharmacy and Pharmaceutical Sciences 2013; 2(2):485-508

[53]. Bi Y. Preparation and evaluation of a compressed tablet rapidly disintegrating in the oral cavity. Chemical and Pharmaceutical Bulletin 1996; 44: 2121-2127.

[54]. Kumari S, Visht S, Sharma PK, Yadav RK. Fast dissolving Drug delivery system: Review Article. Journal of Pharmacy Research, 2010; 3(6): 1444-1449.

Regular Issue Subscription Review Article
Volume 16
Issue 03
Received 18/06/2025
Accepted 07/07/2025
Published 26/07/2025
Publication Time 38 Days
109

[first_name] [last_name]

My IP

PlumX Metrics