Biopolymer-Based Nanocomposites for Oral Drug Delivery

Year : 2025 | Volume : 13 | Special Issue 04 | Page : 400 412
    By

    R. A. Waikar,

  • Udugade S. B.,

  • Amit Chaudhary,

  • Avinash M. Pawar,

  1. Professor, Department of Mechanical Engineering, Vishwakarma Institute of Technology, Pune, Maharashtra, India
  2. Associate Professor, Department of Pharmaceutics, Krishna Vishwa Vidyapeeth (Deemed to be University), Krishna Institute of Pharmacy, Karad, Maharashtra, India
  3. Associate Professor, Department of Mechanical Engineering, Dr. D.Y. Patil Institute of Technology, Pimpri, Pune, Maharashtra, India
  4. Associate Professor, Department of Engineering Sciences and Allied Engineering, Bharati Vidyapeeth’s College of Engineering for Women, Pune, Maharashtra, India

Abstract

Because they are biocompatible, biodegradable, and can hold a lot of different healing agents, biopolymer-based nanocomposites are looking like a good way to give drugs orally. These materials are made up of natural polymers mixed with nanoparticles. They have many benefits for drug delivery systems, such as making drugs more soluble, controlling when they are released, and making enclosed drugs more stable. Drug release rates may be altered by mixing nanoparticles metal or carbon-based particles into biopolymer frameworks. This enables focused and long-distance movement to certain digestive system sites. This strategy may solve the issues with current medication delivery systems including their undesirable side effects, fast breakdown rate, and poor performance of normal drugs. Selecting the appropriate biopolymers such as polysaccharides, proteins, or lipids which may then be transformed into nanocomposites utilising various techniques, like electrospinning, liquid casting, and coacervation helps one create biopolymer-based nanocomposites. The kinds of nanoparticles utilised, along with their size, form, and any surface modifications, determine how well the system distributes medications. Furthermore, the biopolymer structure protects the medicine within from being broken down by enzymes and outside stressors, therefore reaching its intended location intact. For the treatment of disorders requiring focused therapy in the digestive system, these nanocomposites might also be able to release medications in a regulated and particular manner. As the science advances, biopolymer-based nanocomposites together with existing production techniques offer great promise for improving oral medication delivery systems.

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Keywords: Biopolymer-based nanocomposites, oral drug delivery, controlled release, biocompatibility, nanoparticles.

[This article belongs to Special Issue under section in Journal of Polymer and Composites (jopc)]

How to cite this article:
R. A. Waikar, Udugade S. B., Amit Chaudhary, Avinash M. Pawar. Biopolymer-Based Nanocomposites for Oral Drug Delivery. Journal of Polymer and Composites. 2025; 13(04):400-412.
How to cite this URL:
R. A. Waikar, Udugade S. B., Amit Chaudhary, Avinash M. Pawar. Biopolymer-Based Nanocomposites for Oral Drug Delivery. Journal of Polymer and Composites. 2025; 13(04):400-412. Available from: https://journals.stmjournals.com/jopc/article=2025/view=211749


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References

  1. Nair, V.V.; Cabrera, P.; Ramírez-Lecaros, C.; Jara, M.O.; Brayden, D.J.; Morales, J.O. Buccal delivery of small molecules and biologics: Of mucoadhesive polymers, films, and nanoparticles–an update. Int. J. Pharm. 2023, 636, 122789.
  2. Anand, R.; Kumar, A. Significant biopolymers and their applications in buccal mediated drug delivery. J. Biomater. Sci. Polym. Ed. 2021, 32, 1203–1218.
  3. Mura, P.; Maestrelli, F.; Cirri, M.; Mennini, N. Multiple roles of chitosan in mucosal drug delivery: An updated review. Mar. Drugs 2022, 20, 335.
  4. Kumar, A.; Naik, P.K.; Pradhan, D.; Ghosh, G.; Rath, G. Mucoadhesive formulations: Innovations, merits, drawbacks, and future outlook. Pharm. Dev. Technol. 2020, 25, 797–814.
  5. Macedo, A.S.; Castro, P.M.; Roque, L.; Thomé, N.G.; Reis, C.P.; Pintado, M.E.; Fonte, P. Novel and revisited approaches in nanoparticle systems for buccal drug delivery. J. Control. Release 2020, 320, 125–141.
  6. Şenel, S. An overview of physical, microbiological and immune barriers of oral mucosa. Int. J. Mol. Sci. 2021, 22, 7821.
  7. Vielmuth, F. Anatomy of the Oral Mucosa. In Diseases of the Oral Mucosa; Schmidt, E., Ed.; Springer: Cham, Switzerland, 2021; pp. 5–19.
  8. Roy, R.R.; Shimada, K.; Murakami, S.; Hasegawa, H. Contribution of transglutaminases and their substrate proteins to the formation of cornified cell envelope in oral mucosal epithelium. Eur. J. Oral Sci. 2021, 129, e12760.
  9. Évora, A.S.; Adams, M.J.; Johnson, S.A.; Zhang, Z. Corneocytes: Relationship between structural and biomechanical properties. Ski. Pharmacol. Physiol. 2021, 34, 146–161.
  10. Golchha, P. Khobragade and A. Talekar, “Design of an Efficient Model for Health Status Prediction Using LSTM, Transformer, and Bayesian Neural Networks,” 2024 International Conference on Innovations and Challenges in Emerging Technologies (ICICET), Nagpur, India, 2024, pp. 1-5, doi: 10.1109/ICICET59348.2024.10616353.
  11. Trincado, V.; Gala, R.P.; Morales, J.O. Buccal and sublingual vaccines: A review on oral mucosal immunization and delivery systems. Vaccines 2021, 9, 1177.
  12. Pinto, S.; Pintado, M.E.; Sarmento, B. In Vivo, Ex Vivo and In Vitro assessment of buccal permeation of drugs from delivery systems. Expert Opin. Drug Deliv. 2020, 17, 33–48.
  13. Amézqueta, S.; Subirats, X.; Fuguet, E.; Rosés, M.; Ràfols, C. Octanol-Water Partition Constant. In Handbooks in Separation Science, Liquid-Phase Extraction; Poole, C.F., Ed.; Elsevier: Amsterdam, The Netherlands, 2020; pp. 183–208.
  14. Wanasathop, A.; Patel, P.B.; Choi, H.A.; Li, S.K. Permeability of buccal mucosa. Pharmaceutics 2021, 13, 1814.
  15. He, S.; Mu, H. Microenvironmental pH modification in buccal/sublingual dosage forms for systemic drug delivery. Pharmaceutics 2023, 15, 637.
  16. Duceac, I.A.; Coseri, S. Biopolymers and their derivatives: Key components of advanced biomedical technologies.  Adv.2022, 61, 108056.
  17. Sumit S. Pakhare, Jayant Y. Hande, Shruti K. Patle, Rajani A. Bhoyar. (2016). A Review of q-deformation in Nonlinear Maps. Advance Physics Letter, 3(4), 28-33
  18. M. Ghushe, S.U. Bhonsule, A.D. Deshpande, S.S. Soley, A.A. Dani. (2016). Nanotechnology: A Review. Advance Physics Letter, 3(4), 34-36
  19. Palaniappan, M., Palanisamy, S., Khan, R. et al. Synthesis and suitability characterization of microcrystalline cellulose from Citrus x sinensis sweet orange peel fruit waste-based biomass for polymer composite applications. J Polym Res 31, 105 (2024). https://doi.org/10.1007/s10965-024-03946-0
  20. Palanisamy, S., Mayandi, K., Palaniappan, M., Alavudeen, A., Rajini, N., Vannucchi de Camargo, F., & Santulli, C. (2021). Mechanical Properties of Phormium Tenax Reinforced Natural Rubber Composites. Fibers.
  21. Karuppiah, G.; Kuttalam, K.C.; Palaniappan, M.; Santulli, C.; Palanisamy, S. Multiobjective Optimization of Fabrication Parameters of Jute Fiber/Polyester Composites with Egg Shell Powder and Nanoclay Filler. Molecules 2020, 25, 5579.
  22. Palanisamy, S.; Kalimuthu, M.; Santulli, C.; Palaniappan, M.; Nagarajan, R.; Fragassa, C. Tailoring Epoxy Composites with Acacia caesia Bark Fibers: Evaluating the Effects of Fiber Amount and Length on Material Characteristics. Fibers 2023, 11, 63.
  23. Palanisamy, Sivasubramanian, Tabrej Khan, Omar Shabbir, Shien Ming and Wu. “Mechanical, morphological and wear resistance of natural fiber / glass fiber-based polymer composites.” BioResources (2024): n. pag.
Special Issue Subscription Review Article
Volume 13
Special Issue 04
Received 20/03/2025
Accepted 19/05/2025
Published 01/06/2025
Publication Time 73 Days
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