Review on Unveiling The Shadow Of Hyperpigmentation

Year : 2025 | Volume : 15 | 02 | Page : –
    By

    Patil Kirtesh Yashwant,

  • Akash S. Jain,

  • Divakar R. Patil,

  • Azam Z.Shaikh,

  • Sameer R. Shaikh,

  • Hitendra S. Chaudhari,

  1. Student, Department of Pharmaceuties, P. S. G. V. P. Mandal’s College of Pharmacy, shahada, Maharashtra, India
  2. Associate Professor, Department of Pharmaceutical Chemistry, P. S. G. V. P. Mandal’s College of Pharmacy, shahada, Maharashtra, India
  3. Associate Professor, Department of Pharmaceutical Chemistry, P. S. G. V. P. Mandal’s College of Pharmacy, shahada, Maharashtra, India
  4. Associate Professor, Department of Pharmaceutical Chemistry, P. S. G. V. P. Mandal’s College of Pharmacy, shahada, Maharashtra, India
  5. Associate Professor, Department of Pharmaceutical Chemistry, P. S. G. V. P. Mandal’s College of Pharmacy, shahada, Maharashtra, India
  6. Associate Professor, Department of Pharmaceutical Chemistry, P. S. G. V. P. Mandal’s College of Pharmacy, shahada, Maharashtra, India

Abstract

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Natural products offer promising solutions for treating skin pigmentation disorders due to their non-toxic properties and effective mechanisms of action. Studies highlight their safety and efficacy through methods such as cytotoxicity tests, tyrosinase activity assays, and melanogenesis inhibition evaluations. Advanced delivery systems like liposomes and nanoparticles further enhance their performance by improving solubility and skin penetration. Skin pigmentation disorders, influenced by factors such as UV radiation, hormonal changes, and inflammation, result in melanin overproduction and uneven skin tone. Eumelanin and pheomelanin, the two primary pigments, play distinct roles in skin protection and temperature regulation. Historically, pigmentation has been unjustly linked to racial biases, reflecting societal discrimination. Modern treatment options, including hydroquinone and tranexamic acid, provide targeted therapies, though the misuse of corticosteroids remains a concern. The development and application of natural products in pigmentation treatment combine efficacy, safety, and economic benefits, offering a sustainable approach to managing these conditions.

Keywords: Skin pigmentation, tyrosinase inhibitors, hypopigmentation, hyperpigmentation, vitiligo, skin lightening, depigmentation

How to cite this article:
Patil Kirtesh Yashwant, Akash S. Jain, Divakar R. Patil, Azam Z.Shaikh, Sameer R. Shaikh, Hitendra S. Chaudhari. Review on Unveiling The Shadow Of Hyperpigmentation. Research and Reviews: A Journal of Pharmacology. 2025; 15(02):-.
How to cite this URL:
Patil Kirtesh Yashwant, Akash S. Jain, Divakar R. Patil, Azam Z.Shaikh, Sameer R. Shaikh, Hitendra S. Chaudhari. Review on Unveiling The Shadow Of Hyperpigmentation. Research and Reviews: A Journal of Pharmacology. 2025; 15(02):-. Available from: https://journals.stmjournals.com/rrjop/article=2025/view=0

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Ahead of Print Subscription Review Article
Volume 15
02
Received 25/03/2025
Accepted 17/04/2025
Published 08/05/2025
Publication Time 44 Days
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