Pharmacogenomics in Anesthesia: Individualized Drug Responses

Year : 2025 | Volume : 15 | Issue : 01 | Page : 83 95
    By

    Tehseen Irshad,

  • Bilal,

  • Sowby Jan,

  1. Assistant Professor, St.Soldier Group of Institutions, Jalandhar, Punjab, India
  2. Anaesthesiologist, Government Medical College (GMC), and Associated Hospital, Baramulla, Jammu & Kashmir, India
  3. Assistant Professor, St.Soldier Group of Institutions, Jalandhar, Punjab, India

Abstract

Pharmacogenomics is the study of how a person’s genes influence how they react to medications. Pharmacology, the study of medications, and genomics, the examination of genes and their functions, merge in this field to develop safe, effective drugs that can be prescribed based on an individual’s genetic makeup. Pharmacogenomics examines how an individual’s unique genetic makeup can influence their responses to certain drugs. In anesthesia, where individual responses to pain relievers are vital, it is particularly relevant. Pharmacogenomics examines how genetic differences influence drug dosage, response, metabolism, and safety outcomes. Anesthetics and the perioperative phase are promising subjects for pharmacogenetic studies due to the narrow therapeutic ranges of anesthesia drugs, variations in patient responses to anesthesia, and the risks associated with surgical procedures. Anesthesia specialists aim to reduce risks and negative impacts linked to anesthesia, while also enhancing the administration of anesthesia and improving patient results. The most important developments in the knowledge and use of genetics in pharmacology have thus far taken place outside of anesthesiology, even though pharmacogenomics originated in the field of anesthesia.

Keywords: Pharmacogenomics, anesthesiology, personalized medicine, isoflurane, single nucleotide polymorphisms

[This article belongs to Research and Reviews: A Journal of Pharmacology ]

How to cite this article:
Tehseen Irshad, Bilal, Sowby Jan. Pharmacogenomics in Anesthesia: Individualized Drug Responses. Research and Reviews: A Journal of Pharmacology. 2025; 15(01):83-95.
How to cite this URL:
Tehseen Irshad, Bilal, Sowby Jan. Pharmacogenomics in Anesthesia: Individualized Drug Responses. Research and Reviews: A Journal of Pharmacology. 2025; 15(01):83-95. Available from: https://journals.stmjournals.com/rrjop/article=2025/view=208627


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Regular Issue Subscription Review Article
Volume 15
Issue 01
Received 06/02/2025
Accepted 04/03/2025
Published 23/04/2025
Publication Time 76 Days
443

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