Pharmacokinetics and Pharmacodynamics Studies of Chia Seed Derived Compounds; A Review

Year : 2025 | Volume : 12 | Issue : 01 | Page : 9 15
    By

    Mohd.Wasiullah,

  • Piyush Yadav,

  • Deepak Kumar Patel,

  1. Principal, Dept.of Pharmacy, Prasad Institute of Technology, Jaunpur, Uttar Pradesh, India
  2. Professor &Head, Department of Pharmaceutical Chemistry, Prasad Institute of Technology, Jaunpur, Uttar Pradesh, India
  3. Scholor, Dept.of Pharmacy, Prasad Institute of Technology, Jaunpur, Uttar Pradesh, India

Abstract

Chia seeds (Salvia hispanica L.) have been historically valued by ancient civilizations and are increasingly being recognized for their powerful nutritional and therapeutic properties. Rich in omega-3 fatty acids, polyphenols, fiber, and essential minerals, chia seeds are gaining attention for their potential health benefits. This review examines the pharmacokinetics and pharmacodynamics of chia seed-derived compounds, with emphasis on their absorption, distribution, metabolism, and elimination processes, as well as their biological effects. Chia-derived omega-3 fatty acids, polyphenols, and fiber promote anti-inflammatory, antioxidant, cardiovascular, neuroprotective, and gastrointestinal benefits. Despite the promising results of clinical research, there are some issues such as biological utilization and low restrictions on production. As functional foods, chia seeds offer significant potential for improving health and preventing chronic diseases, although further research is needed to fully optimize their therapeutic applications.

Keywords: Chia seeds, functional foods, salvia hispanica L, bioactive compounds, Chia seed oil.

[This article belongs to Research & Reviews: A Journal of Drug Design & Discovery ]

How to cite this article:
Mohd.Wasiullah, Piyush Yadav, Deepak Kumar Patel. Pharmacokinetics and Pharmacodynamics Studies of Chia Seed Derived Compounds; A Review. Research & Reviews: A Journal of Drug Design & Discovery. 2025; 12(01):9-15.
How to cite this URL:
Mohd.Wasiullah, Piyush Yadav, Deepak Kumar Patel. Pharmacokinetics and Pharmacodynamics Studies of Chia Seed Derived Compounds; A Review. Research & Reviews: A Journal of Drug Design & Discovery. 2025; 12(01):9-15. Available from: https://journals.stmjournals.com/rrjoddd/article=2025/view=193694


References

  1. Urbizo-Reyes U, San Martin-González MF, Garcia-Bravo J, Vigil AL, Liceaga AM. Physicochemical characteristics of chia seed (Salvia hispanica) protein hydrolysates produced using ultrasonication followed by microwave-assisted hydrolysis. Food hydrocolloids. 2019 Dec 1;97:105187. https://doi.org/10.1016/j.foodhyd.2019.105187
  2. Coates, Wayne; Ayerza, Ricardo (1998). “Commercialproductionofchia in Northwestern Argentina”. Journal of the American Oil Chemists’Society. 75 (10): 1417–1420.
  3. Sinclair AJ, Begg D, Mathai M, Weisinger RS. Omega 3 fatty acids and the brain: review of studies in depression. Asia Pac J Clin Nutr. 2007;16 Suppl 1:391-7.
  4. Grancieri M, Martino HSD, Gonzalez de Mejia E. Chia Seed (Salvia hispanica L.) as a Source of Proteins and Bioactive Peptides with Health Benefits: A Review. Compr Rev Food Sci Food Saf. 2019 Mar;18(2):480-499. doi: 10.1111/1541-4337.12423.
  5. Fateh HL, Ahmed DH, Najafabadi MS, Moludi J. The impact of chia seeds on diabetes, blood pressure, lipid profile, and obesity indicators: Systematic review and meta-regression analysis of 14 randomized controlled trials. Prostaglandins Other Lipid Mediat. 2024 Dec;175:106907. doi: 10.1016/j.prostaglandins.2024.106907.
  6. Ullah R, Nadeem M, Khalique A, Imran M, Mehmood S, Javid A, Hussain J. Nutritional and therapeutic perspectives of Chia (Salvia hispanica L.): a review. J Food Sci Technol. 2016 Apr;53(4):1750-8. doi: 10.1007/s13197-015-1967-0.
  7. Nieman DC, Gillitt N, Jin F, Henson DA, Kennerly K, Shanely RA, Ore B, Su M, Schwartz S. Chia seed supplementation and disease risk factors in overweight women: a metabolomics investigation. The journal of alternative and complementary medicine. 2012 Jul 1;18(7):700-8. https://doi.org/10.1089/acm.2011.0443
  8. Luz JM, Nunes MD, Paes SA, Torres DP, Silva MD, Kasuya MC. Lignocellulolytic enzyme production of Pleurotus ostreatus growth in agroindustrial wastes. Brazilian Journal of Microbiology. 2012;43(4) :1508-15. https://doi.org/10.1590/S1517-83822012000400035
  9. Reyes-Caudillo, E.; Tecante, A.; Valdivia-López, M.A. Dietary fibre content and antioxidant activity of phenolic compounds present in Mexican chia (Salvia hispanicaL.) seeds. Food Chem. 2008, 107(2), 656–663. https://doi.org/10.1016/j.foodchem.2007.08.062
  10. Ranjana D, Akan D. Advances in Chia Seed Research. Adv Biotech & Micro. 2017; 5(2): 555661. DOI: 10.19080/AIBM.2017.05.555662
  1. Ali NM, Yeap SK, Ho WY, Beh BK, Tan SW, Tan SG. The promising future of chia, Salvia hispanica L. Journal of Biomedicine and Biotechnology. 2012;2012. https://doi.org/10.1155/2012/171956
  2. Ullah, R., Nadeem, M., Khalique, A. et al.Nutritional and therapeutic perspectives of Chia (Salvia hispanica): a review. J Food Sci Technol 53, 1750–1758 (2016). https://doi.org/10.1007/s13197-015-1967-0
Regular Issue Subscription Review Article
Volume 12
Issue 01
Received 14/12/2024
Accepted 04/01/2025
Published 13/01/2025
378

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