An Overview of Berberis lycium Royle’s Medicinal Significance

Year : 2024 | Volume : | : | Page : –
By

Deepika,

Komal Pathania,

Lovish Sharma,

Ankur Thakur,

  1. Assistant Professor, School of Pharmacy and Emerging Sciences, Baddi University of Emerging Sciences & Technology, Baddi, District Solan, Himachal Pradesh, India
  2. Assistant Professor, School of Pharmacy and Emerging Sciences, Baddi University of Emerging Sciences & Technology, Baddi, District Solan, Himachal Pradesh, India
  3. Assistant Professor, Department of Pharmaceutical Chemistry, School of Pharmacy, Chitkara University, Baddi, District Solan, Himachal Pradesh, India
  4. Assistant Professor, Department of Pharmaceutical Chemistry, School of Pharmacy, Chitkara University, Baddi, District Solan, Himachal Pradesh, India

Abstract

Natural medication substances are acknowledged as essential and playing important roles in the current medical system because their therapeutic effects are dependent upon the availability of these bioactive molecules. Natural medicines are extremely helpful since they provide necessary bioactive compounds that are less harmful but nonetheless more potent because of their ability to prevent disease. In 1837, John Forbes Royle wrote the first description of the B. lycium plant. The Berberidaceae family comprises 450–500 deciduous and evergreen shrub species. This genus holds significant importance in diverse Indian Himalayan medical traditions. Indigenous to South Asia, including India, Nepal, Pakistan, and Afghanistan, the plant yields berries as its fruits. The flowers are initially bright yellow, turning purplish as the fruits ripen. The berries are oval, measuring approximately 7mm in length, 4mm in diameter, and weighing 227mg. Flowering of this plant take place in April to May and fruiting occurs in September to October and June to July. Whereas, abundant in various chemicals, the plant contains Glycosides, Alkaloid, Tannins, Flavonoids, Saponins, Triterpenoids, Carbohydrates, Phenolic Acid, Steroids, and Reducing sugar. With a wide array of beneficial properties, this medicinal plant exhibits Antibacterial effects, Anti-inflammatory effects, efficient microorganism elimination, acts as an aperient with a gentle laxative effect, and possesses various Pharmacological properties.

Keywords: Berberis lycium, Berberine, Alkaloids, Pharmacological properties, Medicinal Plant.

How to cite this article:
Deepika, Komal Pathania, Lovish Sharma, Ankur Thakur. An Overview of Berberis lycium Royle’s Medicinal Significance. Research & Reviews: A Journal of Pharmaceutical Science. 2024; ():-.
How to cite this URL:
Deepika, Komal Pathania, Lovish Sharma, Ankur Thakur. An Overview of Berberis lycium Royle’s Medicinal Significance. Research & Reviews: A Journal of Pharmaceutical Science. 2024; ():-. Available from: https://journals.stmjournals.com/rrjops/article=2024/view=176183


Full Text PDF for email

References

[1] J. D. Jussieu, de. Berberidaceae, nom. cons. Genera Plantarum, (1789) 286.
[2] C. Brückner, Clarification of the carpel number in Papaverales, Capparales, and Berberidaceae, The Botanical Review, 66 (2000), 155-307.
[3] A. K. Anwar, M. Ashfaq & M. A. Nasveen, Pharmacognostic studies of selected indigenous plants of Pakistan, Pakistan Forest Institute, Peshawar NWFP, Pakistan, (1979) 15-35.
[4] S. R. Baquar, Medicinal and poisonous plants of Pakistan, Medicinal and poisonous plants of Pakistan (1989).
[5] K. Usmanghani, A. Saeed and M. T. Alam, Indusyunic medicine, (Karachi, Pakistan: University of Karachi press), (1997) 120.
[6] K. M. Nadkarni, Indian Material Medica, (Bombay, India: Popular Parakashan Depot), (1980) 180-190.
[7] A. Rajasekaran & J. Pant, The genus Berberis linn.: A review. Pharmacognosy Review, 2 (2008) (4).
[8] D. Bhardwaj & N. Kaushik, Phytochemical and pharmacological studies in genus Berberis. Phytochemistry reviews, 11 (2012) 523-542.
[9] R. Sharma, Medicinal plants of India: an encyclopaedia, Daya Books, (2003).
[10] Dhar U, Kachroo P. Alpine Flora of Kashmir Himalaya. Brittonia. 1983 Oct;35(4):379.
[11] A. H. Irshad, A. H. Pervaiz, Y. B. Abrar, I. Fahelboum & B. Z Awen, (2013), Antibacterial activity of Berberis lycium root extract, Trakia J. Sci, 1 (2023) 88-90.
[12] S. A. Parra, K. Gaur, L. S. Ranawat & M. I. Rather, An overview on various aspects of plant Berberis Lycium Royale, Am. J. Pharmacol. Sci, 6 (2008) 19-24.
[13] S. Srivastava & A. K. S. Rawat, Quality evaluation of ayurvedic crude drug daruharidra, its allied species, and commercial samples from herbal drug markets of India. Evidence-Based Complementary and Alternative Medicine 2013;2013(1):472973.
[14] M. C. Furrianca, M. Alvear, T. Zambrano, L. Barrientos, V. Fajardo & L. A. Salazar, Medicinal value of the Berberis genus as hypoglycemic agent, Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas, 14 (2015) 423-441.
[15] P. Sood, R. Modgil & M. Sood, Physico-chemical and nutritional evaluation of indigenous wild fruit Kasmal, Berberis lycium Royle, Indian Journal of Natural Products and Resources Vol. 1(3), September 2010, pp. 362-366
[16] Ahmed M, Alamgeer A, Sharif T, Zabta CH M, Akbar A. Effect of Berberis lycium Royle on lipid profile in alloxan induced diabetic rabbits. Ethnobotanical leaflets. 2009;2009(6):4.
[17] H. Wang, Zhu C, Ying Y, Luo L, Huang D, Luo Z. Metformin and berberine, two versatile drugs in treatment of common metabolic diseases. Oncotarget. 2018 Feb 2;9(11):10135.
[18] S. K. Srivastava, V. Rai, M. Srivastava, A. K. S. Rawat & S. Mehrotra, Estimation of heavy metals in different Berberis species and its market samples, Environmental monitoring and assessment, 116 (2006) 315-320.
[19] K. Mustafa, H. Mohamed, A. M. Yu. S. Shah, M. Akhlaq, H. Xiao & Y. Song, In vitro anticancer potential of Berberis lycium Royle extracts against human hepatocarcinoma (HepG2) cells, BioMed Research International, 2020;2020(1):8256809.
[20] S. Ahmed, M. Shuaib, K. Ali, S. Ali & F. Hussain, Evaluation of different parts of Berberis lyceum and their biological activities: a review, Pure and Applied Biology (PAB), 2017 Aug 23;6(3):897-907.
[21] M. Gulfraz, M. Arshad, N. Nayyer, N. Kanwal & U. Nisar, Investigation for bioactive compounds of Berberis lyceum royle and Justicia adhatoda L. Ethnobotanical leaflets, 2004;2004(1):5.
[22] S. Shaista, T. Kalim, R. Naghmana, N. Sidra, M. Bilal, S. Muhammad Ajmal & S. Mohammad, Phytochemical and antioxidant studies of Berberis lycium, Pakistan Journal of Pharmaceutical Sciences. 2013; 26 (6): 1165-1172.
[23] P. Sharma, A. Awasthi & I. Gupta, Phytochemical investigation and evaluation of anti-oxidant potential of Berberis lycium roots from Himachal Pradesh. Journal of Pharmacognosy and Phytochemistry, 2019;8(3):4740-5.
[24] M. Ahmed, A. Alamgeer, T. Sharif, CH. M. Zabta & A. Akbar, Effect of Berberis lycium Royle on lipid profile in alloxan induced diabetic rabbits. Ethnobotanical leaflets 2009;2009(6):4.
[25] S. Garhwal, Analysis of berberine content using HPTLC fingerprinting of root and bark of three Himalayan Berberis species. Asian Journal of Biotechnology, 2010;2(4):239-45.
[26] Uniyal, K. N. Singh, P. Jamwal & B. Lal Traditional use of medicinal plants among the tribal communities of Chhota Bhangal, Western Himalaya, Journal of ethnobiology and ethnomedicine, 2 (2006) Article number-14,1-8 .
[27] S. M. Hasanuzzaman, Guide on Medicinal and aromatic plants of SAARC countries, SAARC Agricultural Information Center CSAIC, (2006).
[28] Hassan M, Dar BN, Rather SA, Akhter R, Huda AB. Physico-chemical, sensory and microbial characteristics of fruit flavoured milk based beverages during refrigerated storage. Adv Biomed Pharma. 2015;2:32-9.
[29] M. Ahmed, Sharif T. Alamgeer, CHM. Zabta and A. Akbar A, Effect of Berberis lycium on Lipid Profile in Alloxan Induced Diabetic Rabbits, Ethnobot, Leaflets 13 (2009) 702-708.
[30] M. Gulfraz, G. Qadir, F. Nosheen & Z. Parveen, Antihyperglycemic effects of Berberis lyceum Royle in alloxan induced diabetic rats, Diabetologia croatica, 36 (2007) 49-54.
[31] M. Gulfraz, S. Mehmood, A. Ahmad, N. Fatima, Z. Praveen and E. M. Williamson, Comparison of the antidiabetic activity of Berberis lycium root extract and Berberine in Alloxan-induced Diabetic Rats. Phytotherapy Research, 22 (2008) 1208-1212.
[32] W. J. Kong, H. Zhang, D. Q. Song, R. Xue, W. Zhao, J. Wei & J. D. Jiang, Berberine reduces insulin resistance through protein kinase C–dependent up-regulation of insulin receptor expression. Metabolism, 58 (2009), 109-119.
[33] J. Zhou, S. Zhou, J. Tang, K. Zhang, L. Guang, Y. Huang & D. Li, Protective effect of berberine on beta cells in streptozotocin-and high-carbohydrate/high-fat diet-induced diabetic rats, European Journal of Pharmacology, 606 (2009), 262-268.
[34] J. Yin, H. Xing & J. Ye, Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism, 2008 May 1;57(5):712-7.
[35] S. Szeto, C. M. N. Yow & K. W. Fung, Characterization of berberine on human cancer cells in culture. Turkish Journal of Medical Sciences, 2002;32(5):363-8.
[36] Choi MS, Oh JH, Kim SM, Jung HY, Yoo HS, Lee YM, Moon DC, Han SB, Hong JT. Berberine inhibits p53-dependent cell growth through induction of apoptosis of prostate cancer cells. International journal of oncology. 2009 May 1;34(5):1221-30.
[37] S. Letašiová, S. Jantová, L.U. Čipák & M. Múčková, Berberine—antiproliferative activity in vitro and induction of apoptosis/necrosis of the U937 and B16 cells. Cancer letters, 2006 Aug 8;239(2):254-62.
[38] Q. Hou, X. Tang, H. Liu, J. Tang, Y. Yang, X. Jing & Z. Wang, Berberine induces cell death in human hepatoma cells in vitro by downregulating CD147, Cancer science, 2011 Jul;102(7):1287-92.
[39] A. H. Irshad, A. H. Pervaiz, Irshad AH, Pervaiz AH, Abrar YB, Fahelboum I, Awen BZ. Antibacterial activity of Berberis lycium root extract. Trakia J. Sci. 2013 Jan 1;1:88-90.
[40] Singh M, Srivastava S, Rawat AK. Antimicrobial activities of Indian Berberis species. Fitoterapia. 2007 Dec 1;78(7-8):574-6.
[41] M. Singh, S. Srivastava & A. K. S. Rawat, Antimicrobial studies of stem of different Berberis species, Nat Prod Sci, 2009;15(2):60-5.
[42] H. Nidaullah, F. R. Durrani, S. Ahmad, I. U. Jan & S. Gul, Aqueous extract from different medicinal plants as anticoccidial, growth promotive and immunostimulant in broilers. Journal of agricultural and biological science, 2010, Vol. 5, No. 1, 53-59 ref. 20
[43] A. Chevalier, Encyclopedia of medicinal plants, Revised Edition, Sydney (AUS): Dorling Kindersley (2001).
[44] M. Čerňáková & D. Košťálová, Antimicrobial activity of berberine—a constituent of Mahonia aquifolium. Folia microbiologica, 47 (2002) 375-378.
[45] R. B. Sack & J. L. Froehelich, Berberine-one herb in many ways. Altern Med Rev, 5 (2000) 175-7.
[46] G. Lei, H. Dan, L. Jinhua, Y. Wei, G. Song & W. Li, Berberine and itraconazole are not synergistic in vitro against Aspergillus fumigatus isolated from clinical patients, Molecules, 16 (2011) 9218-9233.
[47] Saha P, Bhattacharjee S, Sarkar A, Manna A, Majumder S, Chatterjee M. Berberine chloride mediates its anti-leishmanial activity via differential regulation of the mitogen activated protein kinase pathway in macrophages. PLoS One. 2011 Apr 5;6(4):e18467.
[48] Saha P, Sen R, Hariharan C, Kumar D, Das P, Chatterjee M. Berberine chloride causes a caspase-independent, apoptotic-like death in Leishmania donovani promastigotes. Free radical research. 2009 Jan 1;43(11):1101-10.
[49] M. Ahmad, Hepatocurative Effect of Barriers Lycium (royle) in Hepatotoxic Rabbits, Gomal University journal of research, 2008 Jun 30;24(1):1-9.
[50] Girish C, Koner BC, Jayanthi S, Rao KR, Rajesh B, Pradhan SC. Hepatoprotective activity of six polyherbal formulations in paracetamol induced liver toxicity in mice. Indian Journal of Medical Research. 2009 May 1;129(5):569-78.
[51] M. A. Khan, J. Khan, S. Ullah, S. A. Malik, & M. Shafi, Hepatoprotective effects of Berberis lycium, Galium aparine and Pistacia integerrima in carbon tetrachloride (CCl4)-treated rats. Journal of Postgraduate Medical Institute, 2008;22(2).
[52] X. Ye, Y. Feng, Y. Tong, K. M. Ng, S. Tsao, G. K. Lau & S. Kobayashi, Hepatoprotective effects of Coptidis rhizoma aqueous extract on carbon tetrachloride-induced acute liver hepatotoxicity in rats, Journal of Ethnopharmacology, 2009 Jul 6;124(1):130-6.
[53] Sun X, Zhang X, Hu H, Lu Y, Chen J, Yasuda K, Wang H. Berberine inhibits hepatic stellate cell proliferation and prevents experimental liver fibrosis. Biological and Pharmaceutical Bulletin. 2009 Sep 1;32(9):1533-7.
[54] Zhang BJ, Xu D, Guo Y, Ping J, Chen LB, Wang H. Protection by and anti‐oxidant mechanism of berberine against rat liver fibrosis induced by multiple hepatotoxic factors. Clinical and experimental pharmacology and physiology. 2008 Mar;35(3):303-9.
[55] Asif A, Kakub G, Mehmood S, Khunum R, Gulfraz M. Wound healing activity of root extracts of Berberis lyceum Royle in rats. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives. 2007 Jun;21(6):589-91.
[56] Gentry EJ, Jampani HB, Keshavarz-Shokri A, Morton MD, Vander Velde D, Telikepalli H, Mitscher LA, Shawar R, Humble D, Baker W. Antitubercular natural products: Berberine from the roots of commercial Hydrastis c anadensis powder. Isolation of inactive 8-oxotetrahydrothalifendine, canadine, β-hydrastine, and two new quinic acid esters, hycandinic acid esters-1 and-2. Journal of natural products. 1998 Oct 23;61(10):1187-93.
[57] Bae EA, Han MJ, Kim NJ, KIM DH. Anti-Helicobacter pylori activity of hearbal medicines. Biological and Pharmaceutical Bulletin. 1998 Sep 15;21(9):990-2.990-992.
[58] Sun DA, Courtney HS, Beachey EH. Berberine sulfate blocks adherence of Streptococcus pyogenes to epithelial cells, fibronectin, and hexadecane. Antimicrobial agents and chemotherapy. 1988 Sep;32(9):1370-4.
[59] Wong KK. Mechanism of the aortic relaxation induced by low concentrations of berberine. Planta medica. 1998 Dec;64(08):756-7.
[60] Wen-Fei C, Mao-Hsiung Y, Chieh-Fu C. Mechanism of vasodilatory effect of berberine in rat mesenteric artery. European journal of pharmacology. 1991 Oct 29;204(1):35-40.
[61] E. Olmez & M. Ilhan, Evaluation of the alpha-adrenoceptor antagonistic action of berberine in isolated organs, Arzneimittel-forschung, Arzneimittel-forschung. 1992 Sep 1;42(9):1095-7.
[62] D. G. Kang, E. J. Sohn, E. K. Kwon, J. H. Han, H. Oh & H. S. Lee, Effects of berberine on angiotensin-converting enzyme and NO/cGMP system in vessels, Vascular pharmacology, 2002 Dec 1;39(6):281-6.
[63] Lau CW, Yao XQ, Chen ZY, Ko WH, Huang Y. Cardiovascular actions of berberine. Cardiovascular Drug Reviews. 2001 Sep;19(3):234-44.
[64] Watt G. Dictionary of the Economic Products of India, reprinted edition, Periodical Expert, Delhi, Vol. VI (Pt. IV). 1972;83.
[65] Lahiri SC. Positive and negative inotropic effects of berberine on the cats’ heart. Ann. Biochem. Exper. Med. 1958;18:95.
[66] Anonymous, Wealth of India, Raw Materials, Publications and Information Directorate, SIR New Delhi, Vol. X (1976) 36.
[67] R. B. Sack & J. L. Froehlich, Berberine inhibits intestinal secretory response of Vibrio cholerae and Escherichia coli enterotoxins, Infection and immunity, 35 (1982) 471-475.
[68] Yuan J, Shen XZ, Zhu XS. Effect of berberine on transit time of human small intestine. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi Jiehe Zazhi= Chinese Journal of Integrated Traditional and Western Medicine. 1994 Dec 1;14(12):718-20.
[69] Hostettmann K, Marston A, Maillard M, Hamburger M, editors. Phytochemistry of plants used in traditional medicine. 1995.
[70] Chand N, Durrani FR, Qureshi M, Durrani Z. Role of Berberis lycium in reducing serum cholesterol in broilers. Asian-australasian journal of animal sciences. 2007;20(4):563-8.
[71] Abidi P, Zhou Y, Jiang JD, Liu J. Extracellular signal-regulated kinase–dependent stabilization of hepatic low-density lipoprotein receptor mRNA by herbal medicine berberine. Arteriosclerosis, thrombosis, and vascular biology. 2005 Oct 1;25(10):2170-6.
[72] Lee S, Lim HJ, Park JH, Lee KS, Jang Y, Park HY. Berberine-induced LDLR up-regulation involves JNK pathway. Biochemical and Biophysical Research Communications. 2007 Nov 3;362(4):853-7.
[73] Kulkarni SK, Dhir A. Possible involvement of L-arginine-nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) signaling pathway in the antidepressant activity of berberine chloride. European journal of pharmacology. 2007 Aug 13;569(1-2):77-83.
[74] Kulkarni SK, Dhir A. On the mechanism of antidepressant-like action of berberine chloride. European Journal of Pharmacology. 2008 Jul 28;589(1-3):163-72.
[75] Kulkarni SK, Dhir A. Current investigational drugs for major depression. Expert opinion on investigational drugs. 2009 Jun 1;18(6):767-88.
[76] Kuo CL, Chi CW, Liu TY. The anti-inflammatory potential of berberine in vitro and in vivo. Cancer letters. 2004 Jan 1;203(2):127-37.
[77] Nakamoto K, Tamamoto M, Hamada T. In vitro study on the effects of trial denture cleansers with berberine hydrochloride. The Journal of Prosthetic Dentistry. 1995 Jun 1;73(6):530-3.
[78] Chan MY. The effect of berberine on bilirubin excretion in the rat. The American Journal of Chinese Medicine. 1977;5(02):161-8.

 

 


Ahead of Print Subscription Review Article
Volume
Received September 17, 2024
Accepted September 23, 2024
Published September 28, 2024

Check Our other Platform for Workshops in the field of AI, Biotechnology & Nanotechnology.
Check Out Platform for Webinars in the field of AI, Biotech. & Nanotech.