A Systematic Review of Method Development and Validation for Ramipril Analysis Using Hplc in Cardiovascular Research

Year : 2024 | Volume :15 | Issue : 02 | Page : –
By

Devshree Yashwantbhai Patel,

Dr. Javesh Kashinath Patil,

Harsha Vasudev Chaudhari,

Aniket Rajesing Girase,

  1. Research Scholar Department of Pharmaceutical Quality Assurance P.S.G.V.P. Mandal’s College of Pharmacy Shahada, Dist – Nandurbar ,425409 Maharashtra India
  2. Associate Professor Department of Pharmaceutical Quality Assurance P.S.G.V.P. Mandal’s College of Pharmacy Shahada, Dist – Nandurbar ,425409 Maharashtra India
  3. Research Scholar Department of Pharmaceutical Quality Assurance P.S.G.V.P. Mandal’s College of Pharmacy Shahada, Dist – Nandurbar ,425409 Maharashtra India
  4. Research Scholar Department of Pharmaceutical Quality Assurance P.S.G.V.P. Mandal’s College of Pharmacy Shahada, Dist – Nandurbar ,425409 Maharashtra India

Abstract

The field of analytical chemistry encompasses a variety of methods that are crucial in determining the chemical composition of different substances. UV-visible spectroscopy and high-performance liquid chromatography (HPLC) are two widely utilized methods that are the subject of this article. UV-visible spectroscopy uses the Beer-Lambert law to quantify light absorption, which can provide information about the concentration of absorbing species. The method is based on how light and matter interact, with absorption occurring due to molecular electronic transitions. Conversely, high pressure is used in HPLC to separate mixture components according to how well they bind to a stationary phase. Its versatility stems from a variety of separation techniques, such as size exclusion chromatography, ion exchange, partition, and adsorption. Method development and validation are crucial to guaranteeing the dependability of analytical procedures. It is necessary to assess validation variables including specificity, accuracy, precision, linearity, and robustness to make sure a method is appropriate for the task at hand. Various HPLC techniques for the analysis of ramipril, an ACE inhibitor used to treat hypertension and heart failure, have been explored in the literature. These studies investigated different mobile phases and columns, demonstrating the flexibility of HPLC in pharmaceutical analysis. Ramipril works by blocking the renin-angiotensin-aldosterone system (RAAS), which reduces inflammation and vasoconstriction. This abstract provides an extensive review of analytical chemistry techniques, with special emphasis on their importance in pharmaceutical analysis and drug development.

Keywords: Ramipril; Hypertension; Analytical method development; Method Validation; HPLC

[This article belongs to Journal of Modern Chemistry & Chemical Technology(jomcct)]

How to cite this article: Devshree Yashwantbhai Patel, Dr. Javesh Kashinath Patil, Harsha Vasudev Chaudhari, Aniket Rajesing Girase. A Systematic Review of Method Development and Validation for Ramipril Analysis Using Hplc in Cardiovascular Research. Journal of Modern Chemistry & Chemical Technology. 2024; 15(02):-.
How to cite this URL: Devshree Yashwantbhai Patel, Dr. Javesh Kashinath Patil, Harsha Vasudev Chaudhari, Aniket Rajesing Girase. A Systematic Review of Method Development and Validation for Ramipril Analysis Using Hplc in Cardiovascular Research. Journal of Modern Chemistry & Chemical Technology. 2024; 15(02):-. Available from: https://journals.stmjournals.com/jomcct/article=2024/view=166988

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Regular Issue Subscription Review Article
Volume 15
Issue 02
Received May 24, 2024
Accepted August 4, 2024
Published August 14, 2024
Views: 15

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