Satbir Singh,
Kehar Singh,
Yakshita Saini,
Jai Kaushik,
- Associate Professor Department of Pharmaceutics, Pt. LR College of Pharmacy Haryana India
- Associate Professor Department of Pharmaceutics, Pt. LR College of Pharmacy Haryana India
- Under Graduate Department of Pharmacy, Pt. LR College of Pharmacy Haryana India
- Under Graduate Department of Pharmacy, Pt. LR College of Pharmacy Haryana India
Abstract
Now a day’s researcher’s curiosity about gastro-retentive drug delivery system (GRDDS) increased so high in recent years because of its excellent drug releasing properties to the target site. The delivery system’s residence time in the stomach can be extended with the usage of GRDDS by using a number of natural and synthetic polymers like guar gum, HPMC (Hydoxy Propyl Methyl Cellulose) which can be used to improve the bioavailability of a certain pharmacological ingredient by releasing the medication at a specific absorption site also improved gastric retention time of drug, hence overcoming the limitations associated with standard oral dose forms. Drug solubility is increased by prolonging the retention of medications in the stomach, especially those with low solubility at high intestinal pH. Both local and systemic effects of GRDDS have been demonstrated to be beneficial in the treatment of duodenal or stomach ulcers. By releasing the medication locally, GRDFs significantly enhance stomach pharmacotherapy by resulting in a high concentration of the drug at the gastric mucosa which has the potential to last for an extended period of time. GRDFs provide continuous and sustained drug release to the upper portion of the gastrointestinal tract (GIT) by lengthening the period of drug release and enhancing the bioavailability of drugs with a small therapeutic window. This prolongs the interval between doses and improves patient compliance. This review aims to provide a brief overview of gastro retentive drug delivery (GRDD), including its associated variables, benefits, and drawbacks. It emphasizes the importance of GRDD over traditional method of administering medication.
Keywords: Bioavailability, gastro retentive drug delivery system (GRDDS), CR, conventional drug dosage form, gastric retention time (GRT).
[This article belongs to Research & Reviews: A Journal of Pharmaceutical Science(rrjops)]
References
1. Kulkarni N, Kulkarni M,Rathod J and Dhole NS: Formulation and evaluation of gastro-retentive floating microspheres:a systemic review . Int J Pharm Sci & Res 2020;11(11):5404–16.doi.13040/IJPSR. 0975 –8232.11(11).5404–16.
2. Amit Kumar Nayak ,RumaMaji, Biswarup Das; Gastroretentive Drug Delivery Systems: A Review; Asian Journal of Pharmaceutical and Clinical Research, 2010;3(1):2–10
3. Benchgaard H, Ladefoged K.Distribution of pellets in gastrointestinal tract: The influence on transit time exerted by the density or diameteof pellets. J Pharm Pharmacol 1978:30(1):690–692.
4. Tortora GJ, Grabowski SR. Principles of Anatomy and Physiology; New York; John Wiley and Sons; 2002.
5. Pund AU,ShendgeRS, Pote Ak Current Approches on Gastroretentive systems.J Drugs Deliv Their. 2020;10(1):139–46
6. Garg S. and Sharma S., et al., Gastroretentive drug delivery system, Business Briefing: Pharmatech, 2003; 160–166.
7. Pant S, Badola A, Kothiyal P. A review on gastroretentive drug delivery system. Indian Journal of Pharmaceutical and Biological Research. 2016 Apr 1;4(2):1.
8. Klausner EA, Lavy E, Friedman M, Hoffman A. expandable gastroretentive dosage forms, journal of control release,2003;90(2):143–162.
9. Malik R, Garg T, Goyal AK, Rath G. Polymeric nanofibers: targeted gastro-retentive drug delivery systems. Journal of Drug Targeting. 2015 Feb 7;23(2):109–24. Available from: http://dx.doi.org/10.3109/1061186X.2014.965715.
10. Deshpande AA, Shah NH, Rhodes CT, Malick W, Development of novel controlled release system for gastric retention, pharma , Res, 1997, Jun 14,815–819.
11. Jain NK: Introduction to novel drug delivery systems. CBS Publishers &Dstibutors New Delhi Second Edition 2017; 175–91.
12. Patel GM, Patel HR, Patel M; Floating drug delivery system an innovative approaches to prolong gastric retention; Pharmainfo.net 2007.
13. Gaba P, Gaba M, Garg R, Dr Gupta, G Floating Microsphere: A Review,6 2008,5.
14. Singh BN and Kim; Floating Drug Delivery Systems; an Approach to Controlled Drug Delivery via Gastric Retention; J. Control. Release. 2000; 63: 235–239.
15. Badoni A, Ojha A, Gnanarajan G, Kothiyal P. Review on gastro retentive drug delivery system. The pharma innovation. 2012 Oct 1;1(8, Part A):32.;
16. Meenakshi Jassal, Ujjwal Nautiyal, Jyotsana Kundlas, Devendra Singh. A review: Gastroretentive drug delivery system [grdds]. Indian J. Pharm.Biol.Res.2015;3(1):82–92
17. Subrahmanyam CV, Setty JT. Laboratory manual of physical pharmaceutics. Jain MK for vallabh prakashan. 2002:147–60.
18. Tripathi J, Thapa P, Maharjan R, Jeong SH. Current state and future perspectives on gastroretentive drug delivery systems. Pharmaceutics. 2019 Apr 20;11(4):193.
19. Fabrcagas JL, Cucala CG, Pous J; Sites R.A. In vitro testing of an antacid formulation with prolonged gastric residence time ;Drug Development and Industrial Pharmacy;1994;20;1199–1212
20. Shah SH, Patel JK, Patel NV. Stomach specific floating drug system : A Review , Int J. Pharm. Res. CODEN (USA): IJPRIF ISSN: 0974 □4304, 2009;623–633.
21. Ashwini A Zanke, Hemant H Gangurde, Anant B Ghonge, Praful S. Chavan. Recent Advance in Gastroretentive Drug Delivery System (GRDDS). Asian Journal of Pharmaceutical Research.2022;12(2):143–9. Doi: 10.52711/2231–5691.2022.00022
Research & Reviews: A Journal of Pharmaceutical Science
| Volume | 15 |
| Issue | 02 |
| Received | May 3, 2024 |
| Accepted | May 23, 2024 |
| Published | July 18, 2024 |