Oxadiazole Derivatives Recent Progress in Synthesis and Bioactivity

Year : 2024 | Volume :15 | Issue : 01 | Page : 62-67
By

Rizwan Arif

Neha Sahu

  1. Assistant Professor Lingaya’s Vidyapeeth, Faridabad Haryana India
  2. Research Scholar Lingaya’s Vidyapeeth, Faridabad Haryana India

Abstract

Over the past few decades, significant advancements have been made in the development of heterocyclic derivatives, leading to the production of numerous novel agents, both synthetic and natural in origin. Because of its numerous biological properties, including antibacterial, antiviral, and antifungal properties, thiazole is a special five-membered heterocyclic motif among heterocyclic compounds. It is utilized as a fundamental building block in many pharmaceutically significant compounds. To the best of our knowledge, there are currently over 90 derivatives containing thiazoles that are being studied clinically, and several thiazole analogs have been given the go-ahead to treat a range of illnesses. Thiazole derivatives can be further thoroughly investigated as the possibly privileged scaffolds in an effort to find novel medications with enhanced therapeutic efficacy and comparable biological targets. In order to help medical researchers rationally create more potent thiazole-containing therapeutic candidates, this article attempts to summarize the uses and synthetic pathways of a few typical thiazole-containing medications that have been approved for use in clinical settings. Numerous significant and powerful pharmaceutical products, such as raltegravir, butalamine, fasiplon, oxolamine, and pleconaril, contain stable isomeric forms of oxadiazoles. Many oxadiazole derivatives are widely used as possible medicinal agents and are quite well-liked. Nonetheless, utilizing biological and in-silico models, several researchers are working and have tried to discover additional synthetic analogues for anticancer, antifungal, and anti-HIV medicines. An effort has been made to highlight the pharmacology and chemistry related to oxadiazole and its derivatives.

Keywords: Oxadiazole, Biological activities, analgesic activity, anti-bacterial activity, anti- convulsant activity, anti-tubercular activity

[This article belongs to Journal of Modern Chemistry & Chemical Technology(jomcct)]

How to cite this article: Rizwan Arif, Neha Sahu. Oxadiazole Derivatives Recent Progress in Synthesis and Bioactivity. Journal of Modern Chemistry & Chemical Technology. 2024; 15(01):62-67.
How to cite this URL: Rizwan Arif, Neha Sahu. Oxadiazole Derivatives Recent Progress in Synthesis and Bioactivity. Journal of Modern Chemistry & Chemical Technology. 2024; 15(01):62-67. Available from: https://journals.stmjournals.com/jomcct/article=2024/view=149971

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Regular Issue Subscription Original Research
Volume 15
Issue 01
Received March 12, 2024
Accepted May 10, 2024
Published June 12, 2024
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