Chompound contaning oxadiazole derivatives and their potential therapeutic uses.

Year : 2024 | Volume :15 | Issue : 01 | Page : 68-74
By

Neha Sahu

Rizwan Arif

  1. Research Scholar Lingaya’s Vidyapeeth, Faridabad Haryana India
  2. Assistant Professor Lingaya’s Vidyapeeth, Faridabad Haryana India

Abstract

Derivatives of oxadiazole or furadi azole rings constitute a significant class of heterocyclic substances. Oxadiazole is a heterocyclic, five-membered ring with two carbons, one oxygen atom, two nitrogen atoms, and two double bonds. They are produced by substituting two nitrogen (-N =) atoms for two methylene groups (= CH) in furan. The furan ring’s aromaticity was significantly decreased by substituting these groups, resulting in a conjugated diene character. There were four distinct oxadiazole isomers that were known to exist: 1,2,4-oxadiazole, 1,2,3-oxadiazole, 1,2,5-oxadiazole, and 1,3,4-oxadiazole. Because of their extensive spectrum of chemical and biological properties, 1,3,4-oxadiazoles and 1,2,4-oxadiazoles are among the ones that researchers are more familiar with and have explored in greater detail. 1,3,4-oxadiazoles are now widely used as synthons in the creation of novel medications. According to published research, the 1,3,4-oxadiazole nucleus derivatives exhibit a range of biological actions, including antioxidant, antiviral, anticancer, antibacterial, and antimycobacterial properties. Commercially accessible medications with a 1,3,4-oxadiazole ring include Furamizole, a nitrofuran derivative with potent antibacterial action, Raltegravir, an antiviral medication, and Nesapidil, a medication used in anti-arrhythmic therapy. The pharmacological activity and different types of synthesis methods for 2, 5-disubstituted 1,3,4-oxadiazole and its related compounds were summarized in this research. The severity and reality of pathogenic bacterial antibiotic resistance necessitate the quick development of novel antimicrobial medications. The main quality control technique in bacteria for recovering ribosomes stopped during translation is trans-translation. Trans-translation is a promising target for new antibiotics or for enhancing the actions of protein synthesis inhibitors that are currently in use because it is missing in eukaryotes but required to prevent ribosomal stalling and is therefore crucial for bacterial survival.

Keywords: Oxadiazole, Biological activities, analgesic activity, anti-bacterial activity, anti- convulsant activity, anti-tubercular activity

[This article belongs to Journal of Modern Chemistry & Chemical Technology(jomcct)]

How to cite this article: Neha Sahu, Rizwan Arif. Chompound contaning oxadiazole derivatives and their potential therapeutic uses.. Journal of Modern Chemistry & Chemical Technology. 2024; 15(01):68-74.
How to cite this URL: Neha Sahu, Rizwan Arif. Chompound contaning oxadiazole derivatives and their potential therapeutic uses.. Journal of Modern Chemistry & Chemical Technology. 2024; 15(01):68-74. Available from: https://journals.stmjournals.com/jomcct/article=2024/view=148434

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Regular Issue Subscription Review Article
Volume 15
Issue 01
Received March 7, 2024
Accepted May 10, 2024
Published May 30, 2024
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