Akansha Vyas,
Gulab Kanwar,
Mukesh Vijayvergia,
Madhu Shekhar Bissa,
Varsha Nagar,
- PG Resident Government Medical College (Kota), Kota Rajasthan India
- Principal and Controller Government, Medical College Rajasthan India
- Deputy Director Salumber Government Hospital Udaipur Rajasthan India
- Senior Resident Government Medical College Rajasthan India
- PG Resident Government Medical College Rajasthan India
Abstract
Diabetes mellitus is a prevalent endocrine metabolic condition that causes significant morbidity and mortality globally. Innumerable metabolic processes within our bodies depend on thyroid hormones. Excess or deficiency in insulin or thyroid hormones might cause functional problems. The intricate relationship between thyroid disorders and diabetes has been recognized for a considerable period. Patients with diabetes have been known to experience thyroid malfunction, the most prevalent kind of which is hypothyroidism. Thyroid issues are more common in diabetics than in the general population. Diabetes mellitus and its consequences are more difficult to treat when thyroid function is altered. The present study was conducted from November 2022 to August 2023 at the Department of Biochemistry, NMCH and MBS Central Laboratory, Government Medical College, Kota, Rajasthan, India. The research participants comprised of 50 individuals with Type 2 Diabetes and 50 healthy controls without diabetes, aged between 40 and 70 years. Thyroid function assessment for all subjects involved testing the thyroid profile, which includes triiodothyronine, thyroxine, and thyroid-stimulating hormone. The observations and interpretations were documented, and the findings were statistically evaluated. It was shown that just 72% of diabetes patients had normal thyroid function. Hypothyroidism was more common than hyperthyroidism among individuals with thyroid disorders (26% versus 2%, respectively). Following additional evaluation for primary and subclinical thyroid disorders, it was shown that among individuals with diabetes, subclinical hypothyroidism (20%) was more prevalent than primary hypothyroidism (6%). Abnormal thyroid hormone levels in type 2 diabetics stem from changes in the hypothalamic–pituitary–thyroid axis, leading to significant metabolic disruptions. Regular testing for thyroid dysfunction in diabetics is crucial, as early identification and treatment can reduce morbidity rates and improve their overall quality of life.
Keywords: diabetes mellitus, hypothyroidism, hormone, thyroxine, metabolic disruptions, subclinical hypothyroidism, primary hypothyroidism
[This article belongs to Research & Reviews: A Journal of Medicine(rrjom)]
References
- Sreelatha M, Kumar VS, Shekar GC, Shekar VC. Study of thyroid profile in patients with type 2 diabetes mellitus. International Journal of Scientific Study. 2017; 5(2): 211–220p.
- Powers A Diabetes Mellitus. In: Longo DN, Kasper DL, Jameson JL, Fauci AS, Hauser SL, Loscalzo J, Eds., Harrison’s Principles of Internal Medicine, 18th Edition, Volume 2. New York: McGraw-Hill Companies, Inc.; 2011. 2968–3009p.
- International Diabetes FIDF Diabetes Atlas, 7th edn. Brussels, Belgium: International Diabetes Federation; 2015. 33.2.
- Irz X, Shankar B, Srinivasan C. Dietary recommendations in the report of a joint WHO/FAO expert consultation on diet, nutrition and the prevention of chronic diseases (WHO Technical Report Series 916, 2003): Potential impact on consumption, production and trade of selected food products: Report for the International Federation of Agricultural Producers and Institute for European Food Studies: 59. Reading: University of Reading Department of Agricultural and Food Economics; 2003. 59p.
- Aschner P, Karuranga S, James S, Simmons D, Basit A, Shaw JE, Wild SH, Ogurtsova K, Saeedi P. The International Diabetes Federation’s guide for diabetes epidemiological studies. Diabetes Research and Clinical P 2021; 172: 108630.
- Yadav SC, Saldhana A, Majumdar B. Status of thyroid profile in type-2 diabetes mellitus. Journal of Nobel Medical College. 2012; 1(2): 64p.
- Park K. Textbook of preventive and social medicine, 19th ed. Jabalpur, India: M/s Banarsidas Bhanot; 2007. 327–332p.
- Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes C 2004; 27(5): 1047–1053p.
- Whiting DR, Guariguata L, Weil C, Shaw J. IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes Research and Clinical P 2011; 94(3): 311–321p.
- Sathisha TG, Cariappa KB, Nirmal Kumar PK, Pavithra V. The impact of T2DM on Thyroid Profile and Outcomes in a Female Population. RJPBCS. 2014; 5(2):
- Jameson JL, Weetman A Disorders of the thyroid gland. In: Fauci AS, Longo DL, Kasper DL, Hauser SL, Jameson JL, Loscalzo J, editors. Harrison’s principles of internal medicine. 18th ed. New York: McGraw Hill; 2008. 2911p.
- Sidhu GK, Malek R, Khubchandani A, Mansuri SH, Patel M, Oza R. A Study of Serum Urea, Creatinine and Uric Acid Levels in Hypothyroid Patients. Int Jr Res 2016; 5(2): 115–118p.
- Udiong CE, Udoh AE, Etukudoh ME. Evaluation of thyroid function in diabetes mellitus in Calabar, Nigeria. Indian Journal of Clinical B 2007; 22: 74–78p.
- Moghetti P, Castello R, Tosi F, Zenti MG, Magnani C, Bolner A, Perobelli L, Muggeo M. Glucose counterregulatory response to acute hypoglycemia in hyperthyroid human subjects. The Journal of Clinical Endocrinology & Metabolism. 1994; 78(1): 169–173p.
- Celani MF, Bonati ME, Stucci N. Prevalence of abnormal thyrotropin concentrations measured by a sensitive assay in patients with type 2 diabetes mellitus. Diabetes Research (Edinburgh, Scotland). 1994; 27(1): 15–25p.
- Singh G, Gupta V, Sharma AK, Gupta N. Evaluation of thyroid dysfunction among type 2 diabetic Punjabi population. Adv Biores. 2011; 2(2): 3–9p.
Research & Reviews: A Journal of Medicine
Volume | 14 |
Issue | 01 |
Received | January 24, 2024 |
Accepted | February 2, 2024 |
Published | April 18, 2024 |