Overview of Diabetic Neuropathy: A Comprehensive Examination

Year : 2024 | Volume : 14 | Issue : 01 | Page : 26 36
    By

    Gyanendra Kumar Gupta,

  • Gagan Devi,

Abstract

Abstract: India has earned the unfortunate distinction of being the global epicenter for diabetes, with an alarming projection of 109 million individuals expected to be afflicted by the condition by 2035The global influence of diabetic neuropathy is significant, with an estimated 132 million individuals affected as of 2010, constituting roughly 1.9% of the global populace. Notably, within the diabetic population, there exists a significantly heightened prevalence The prevalence of sensory peripheral neuropathy stands at 60.4%, with an incidence rate of 8.76%. trend is particularly concerning as individuals age, with the likelihood of neuropathy increasing over time.The pervasive nature of this disease extends beyond national borders, presenting a burgeoning global challenge that profoundly influences daily life. The repercussions of diabetic neuropathy are multifaceted, encompassing sensory impairments, motor dysfunction, and an array of complications that compromise overall well-being. Tasks as seemingly mundane as walking, grasping objects, or even maintaining balance become formidable challenges for those affected. Moreover, the socioeconomic ramifications of diabetic neuropathy are substantial, as individuals contend with reduced productivity, increased healthcare expenditures, and diminished quality of life. Furthermore, the burden extends to caregivers and healthcare systems, amplifying the strain on resources and exacerbating healthcare disparities. Essentially, the widespread and increasing occurrence of diabetic neuropathy emphasizes the critical necessity for comprehensive approaches focused on preventing, detecting early, and managing it effectively. Addressing this multifaceted challenge demands a concerted global effort, encompassing research, policy initiatives, public awareness campaigns, and accessible 2 healthcare services. Only through collective action can we hope to mitigate the profound impact of this global health crisis and alleviate the suffering endured by millions worldwid.

Keywords: Diabetes capital,Sensory peripheral neuropathy,Global problem .

[This article belongs to Research and Reviews: A Journal of Toxicology ]

How to cite this article:
Gyanendra Kumar Gupta, Gagan Devi. Overview of Diabetic Neuropathy: A Comprehensive Examination. Research and Reviews: A Journal of Toxicology. 2024; 14(01):26-36.
How to cite this URL:
Gyanendra Kumar Gupta, Gagan Devi. Overview of Diabetic Neuropathy: A Comprehensive Examination. Research and Reviews: A Journal of Toxicology. 2024; 14(01):26-36. Available from: https://journals.stmjournals.com/rrjot/article=2024/view=137124


References

  1. Goldman L, Schafer AI, editors. Goldman’s Cecil Medicine. 24th ed. Saunders, an imprint of Elsevier; 2012.
  2. Indian Heart Association. Why South Asians? [Internet]. 2015 Apr 30 [cited YYYY MM DD]. Available from: http://indianheartassociation.org/why-indians-why-south-asians/overview
  3. Vos T. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012 Dec 15;380(9859):2163–96.
  4. Battula P, et al. International Journal of Research in Medical Sciences. Int J Res Med Sci. 2017 Sep;5(9):4066-71.
  5. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21274758
  6. Pandit HS, Paradakara S, editor. Ashtanga Hridaya with the commentaries Sarvangasundara of Arundatta and Ayurveda Rasayana of Hemadri, Bhisagacarya. Nidansthan, Chapter 10, Verse 22. Varanasi: Chaukhamba Orientalia; 2000. p. 321.
  7. Trikamji JV, editor. Agnivesha, Charaka, Charaka Samhita, Nidana Sthana, Adhyaya. 2nd ed. Vol. 4. Varanasi: Chaukhamba Sanskrit Sansthan; 1990. p. 325.
  8. Taber’s Cyclopedic Medical Dictionary. 20th ed. Philadelphia: F.A. Davis Company; p. 1462.
  9. Zeng L, Alongkronrusmee D, van Rijn RM. An integrated perspective on diabetic, alcoholic, and drug-induced neuropathy: etiology and treatment in the US. J Pain Res. 2017 Jan 20;10:219–28.
  10. Indian Heart Association. Why South Asians? [Internet]. 2015 Apr 30 [cited YYYY MM DD]. Available from: http://indianheartassociation.org/why-indians-why-south-asians/overview
  11. Vos T. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012 Dec 15;380(9859):2163–96.
  12. Battula P, et al. International Journal of Research in Medical Sciences. Int J Res Med Sci. 2017 Sep;5(9):4066–71.
  13. Available from: https://emedicine.medscape.com/article/1170337
  14. Dorsey RR, Eberhardt MS, Gregg EW, Geiss LS. Control of risk factors among people with diagnosed diabetes, by lower extremity disease status. Prev Chronic Dis. 2009 Oct;6(4):A114.
  15. Tavakkoly-Bazzaz J, Amoli MM, Pravica V, Chandrasekaran R, Boulton AJ, Larijani B. VEGF gene polymorphism association with diabetic neuropathy. Mol Biol Rep. 2010 Mar 30.
  16. Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med. 1993 Sep 30;329(14):977–86.
  17. Harati Y. Diabetes and the nervous system. Endocrinol Metab Clin North Am. 1996 Jun;25(2):325–59.
  18. Rutkove SB. A 52-year-old woman with disabling peripheral neuropathy: review of diabetic polyneuropathy. JAMA. 2009 Oct 7;302(13):1451–8.
  19. Jende JME, Groener JB, Oikonomou D, et al. Diabetic neuropathy differs between type 1 and type 2 diabetes: insights from magnetic resonance neurography. Ann Neurol. 2018 Feb 14.
  20. Ryle C, Donaghy M. Non-enzymatic glycation of peripheral nerve proteins in human diabetics. J Neurol Sci. 1995 Mar;129(1):62–8.
  21. Figueroa-Romero C, Sadidi M, Feldman EL. Mechanisms of disease: the oxidative stress theory of diabetic neuropathy. Rev Endocr Metab Disord. 2008 Dec;9(4):301–14.
  22. American Diabetes Association. Standards of Medical Care in Diabetes—2009. Diabetes Care. 2009;32:S13–61.
Regular Issue Subscription Review Article
Volume 14
Issue 01
Received 05/02/2024
Accepted 09/02/2024
Published 30/03/2024
Publication Time 54 Days
537

Login


My IP

PlumX Metrics