Revolutionizing Anti-Allergy Medications: A Comprehensive Review of Target Discovery and Medicinal Chemistry

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Year : | Volume : 1 | [if 424 equals=”Regular Issue”]Issue[/if 424][if 424 equals=”Special Issue”]Special Issue[/if 424] [if 424 equals=”Conference”][/if 424] : | Page : –

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    Neha Sahu, Rizwan Arif

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  1. Research Scholar, Assistant Professor, Lingaya’s Vidyapeeth, Lingaya’s Vidyapeeth, Haryana, Haryana, India, India

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Abstract

nAbove the past few decades, the prevalence of allergy illnesses has been steadily rising, impacting 20– 30% of the world’s population. Multiple targets are involved in allergic reactions to infections of the skin, digestive tract, and respiratory system. Developing medications with a good curative efficacy and minimal side effects while utilizing novel multi-targets and processes in accordance with the clinical features of various allergic populations and allergens is the primary challenge facing research on anti- allergy therapies. The knowledge on possible therapeutic targets and the medicinal chemistry of synthetic anti-allergy small molecules are the main topics of this review. With reference to leukotriene production, wascium channel blockers, inhibitors of Th2 cytokines, histamine-1/4 receptor antagonists, and leukotrienes, the structure-activity relationship and the mechanism of compound-target interaction were highlighted. The investigation of chemical scaffold optimization and modification for various lead compounds, which is compiled in this review, should serve as a valuable resource for the drug design of related and promising research, such as allergy, in addition to improving the success rate and effectiveness of virtual screening for antiallergic drugs.

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Keywords: Allergic reactions, medications, medicinal chemistry, antiallergic drugs, anti-allergy therapies, synthetic anti-allergy small molecules

n[if 424 equals=”Regular Issue”][This article belongs to International Journal of Advance in Molecular Engineering(ijame)]

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[/if 424][if 424 equals=”Special Issue”][This article belongs to Special Issue under section in International Journal of Advance in Molecular Engineering(ijame)][/if 424][if 424 equals=”Conference”]This article belongs to Conference [/if 424]

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How to cite this article: Neha Sahu, Rizwan Arif Revolutionizing Anti-Allergy Medications: A Comprehensive Review of Target Discovery and Medicinal Chemistry ijame ; :-

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How to cite this URL: Neha Sahu, Rizwan Arif Revolutionizing Anti-Allergy Medications: A Comprehensive Review of Target Discovery and Medicinal Chemistry ijame {cited };:-. Available from: https://journals.stmjournals.com/ijame/article=/view=0

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Volume
[if 424 equals=”Regular Issue”]Issue[/if 424][if 424 equals=”Special Issue”]Special Issue[/if 424] [if 424 equals=”Conference”][/if 424]
Received December 15, 2023
Accepted December 29, 2023
Published

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