Roshni Gat
Abstract
Background:-
In this study, we present compelling evidence that supports the safety and effectiveness of finerenone in individuals diagnosed with type 2 diabetes and chronic renal disease. Our research is dedicated to improving the overall well-being of patients by enhancing their quality of life.
Aim:-
Finerenone exhibited a significant decrease in the likelihood of renal and cardiovascular (CV) events in individuals with both type 2 diabetes and chronic kidney disease. This exploratory subgroup analysis aims to investigate the potential influence of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on the therapeutic efficacy of finerenone.
Material and Method:-
A systemic review was undertaken, during which we scrutinized 5340 cases of these patients.
Result:-
Among the 5340 patients examined, 394 individuals (6.9%) received GLP-1RAs. Regardless of baseline GLP-1RA use, finerenone was associated with a lower UACR, reflected in a ratio of least-squares means of 0.69. The analysis revealed a hazard ratio of 0.67 (95% confidence interval 0.67, 0.72) for patients without GLP-1RA use and 0.63 (95% confidence interval 0.56, 0.70) for those with GLP-1RA use (p value for interaction > 0.20). Importantly, the presence of At baseline, the p values for interaction (> 0.15 and > 0.51, respectively) indicate that the presence of GLP-1RA did not have a significant impact on finerenone’s effectiveness in reducing primary kidney outcomes (defined as time to kidney failure, sustained decrease in estimated glomerular filtration rate ≥40% from baseline, or renal death) or key secondary cardiovascular outcomes (including time to cardiovascular death, non-fatal myocardial infarction, non-fatal stroke, or hospitalization for heart failure) compared to the placebo.
Keywords: Finerenone, Type 2 Diabetes , Chronic kidney Disease,Glomerular filtration, Cardiovascular outcomes, GLP-1 receptor agonists
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| Volume | |
| Issue | |
| Received | January 12, 2024 |
| Accepted | January 24, 2024 |
| Published |
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