Jyoti Prakash
Abstract
This cross-sectional analytical study conducted in a tertiary care center aims to
investigate the clinical profile of Dengue virus-infected patients with a prior
history of COVID-19 within the last three years. Dengue, a prevalent tropical
disease, ranges from mild fever to severe conditions like hemorrhagic fever and
shock syndrome. The study utilizes the World Health Organization’s 2009
classification for Dengue and delineates the febrile, critical, and recovery phases
of infection.
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causing
COVID-19, has become a global pandemic with significant respiratory,
cardiovascular, gastrointestinal, and neurological impacts. The research
question focuses on comparing clinical parameters of Dengue patients at AIIMS
Patna based on their history of prior COVID-19 infection. The primary
objective is to study and compare the clinical profiles, with secondary
objectives exploring the roles of age and gender in prognosis and outcomes.
The study, conducted from September to November 2023, is novel in predicting
Dengue severity in previously COVID-19-infected patients in Bihar. The
sampling involves Dengue-positive patients admitted to the Medicine Ward
using non-randomized convenience purposive sampling. The inclusion criteria
encompass age ≥ 18, positive Dengue markers, and admission during the study
period. The study excludes equivocal or negative Dengue cases and those
without informed consent. Data collection involves comprehensive clinical
assessments and laboratory tests, with statistical analysis planned using
appropriate tests and applications. This research contributes valuable insights
into the interaction of Dengue and prior COVID-19 infections in a region with
limited previous studies on this subject.
Keywords: 1. Dengue 2. Covid-19 3. Dengue IgM 4. Dengue NS1 Ag 5. COVID DENGUE
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References
1.World Health Organization, Special Programme for Research, Training in Tropical
Diseases, World Health Organization. Department of Control of Neglected Tropical
Diseases, World Health Organization. Epidemic, Pandemic Alert. Dengue: guidelines
for diagnosis, treatment, prevention and control. World Health Organization; 2009.
2. Fukusumi M, Arashiro T, Arima Y, Matsui T, Shimada T, Kinoshita H, Arashiro
A, Takasaki T, Sunagawa T, Oishi K. Dengue sentinel traveler surveillance: monthly
and yearly notification trends among Japanese travelers, 2006–2014. PLoS neglected
tropical diseases. 2016 Aug 19;10(8):e0004924.
3.Trofa AF, DeFraites RF, Smoak BL, Kanesa-thasan N, King AD, Burrous JM,
MacArthy PO, Rossi C, Hoke CH. Dengue fever in US military personnel in Haiti.
Jama. 1997 May 21;277(19):1546-8.
4.Leder K, Torresi J, Brownstein JS, Wilson ME, Keystone JS, Barnett E, Schwartz
E, Schlagenhauf P, Wilder-Smith A, Castelli F, von Sonnenburg F. Travel-associated illness
trends and clusters, 2000–2010. Emerging infectious diseases. 2013 Jul;19(7):1049.
5. Kalayanarooj S, Vaughn DW, Nimmannitya S, Green S, Suntayakorn S,
Kunentrasai N, Viramitrachai W, Ratanachu-Eke S, Kiatpolpoj S, Innis BL, Rothman AL.
Early clinical and laboratory indicators of acute dengue illness. Journal of Infectious
Diseases. 1997 Aug 1;176(2):313-21.
6.El‐Qushayri AE, Kamel AM, Reda A, Ghozy S. Does dengue and COVID‐19
co‐infection have worse outcomes? A systematic review of current evidence. Reviews in
Medical Virology. 2022 Sep;32(5):e2339.
7. Ulrich H, Pillat MM, Tárnok A. Dengue fever, COVID‐19 (SARS‐CoV‐2), and
antibody‐dependent enhancement (ADE): a perspective. Cytometry Part A. 2020
Jul;97(7):662-7.
8.Silvestre OM, Costa LR, Lopes BV, Barbosa MR, Botelho KK, Albuquerque KL,
Souza AG, Coelho LA, de Oliveira AJ, Barantini CB, Neves SA. Previous dengue
infection and mortality in coronavirus disease 2019 (COVID-19). Clinical Infectious
Diseases. 2021 Sep 1;73(5):e1219-21.
9.Cardona‐Ospina JA, Arteaga‐Livias K, Villamil‐Gómez WE, Pérez‐Díaz CE,
Katterine Bonilla‐Aldana D, Mondragon‐Cardona Á, Solarte‐Portilla M, Martinez E,
Millan‐Oñate J, López‐Medina E, López P. Dengue and COVID‐19, overlapping
epidemics? An analysis from Colombia. Journal of Medical Virology. 2021 Jan;93(1):522-7.
10.Gérardin P, Maillard O, Bruneau L, Accot F, Legrand F, Poubeau P, Manaquin R,
Andry F, Bertolotti A, Levin C. Differentiating COVID-19 and dengue from other febrile
illnesses in co-epidemics: Development and internal validation of COVIDENGUE scores.
Travel Medicine and Infectious Disease. 2022 Jan 1;45:102232.
11.Malavige GN, Jeewandara C, Ogg GS. Dengue and COVID-19: two sides of the
same coin. Journal of Biomedical Science. 2022 Jul 3;29(1):48.
| Volume | |
| Issue | |
| Received | November 3, 2023 |
| Accepted | December 18, 2023 |
| Published |
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