Open Access
Mahesha C.R.,
Abstract
In recent years, scaffolds have gained increasing attention in the field of tissue engineering, especially in cancer treatment. Nanocomposite scaffolds have emerged as promising candidates for delivering drugs to cancer cells. 3D printing technology has enabled the fabrication of customized scaffolds with precise pore size and complex geometries. This study explores the development of 3D printed scaffolds of nanostructured made of graphene oxide and Poly-Caprolactone (PCL) nanocomposites, which can be magnetically controlled to target cancer cells. The use of graphene oxide in the nanocomposite reinforces the mechanical properties of the scaffolds and improves their biocompatibility. The 3D printing technique used in this study utilizes the 3D-Bioplotter System and NetFab software to translate CAD designs into G code that can be printed on the scaffold. The resulting scaffold exhibits high mechanical strength, biodegradability, and controlled drug release capabilities, which make it a promising candidate for targeted cancer therapy. Overall, the innovative 3D printed scaffolds presented in this study show great potential for improving the efficiency and effectiveness of cancer treatment.
Keywords: 3D printed Scaffolds, drug delivery, CAD, Nano material
[This article belongs to Special Issue under section in Journal of Polymer and Composites(jopc)]
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References
1. J. Ji, C. Wang, Z. Xiong, Y. Pang, and W. Sun, “3D-printed scaffold with halloysite nanotubes laden as a sequential drug delivery system regulates vascularized bone tissue healing,” Materials Today Advances, vol. 15, p. 100259, 2022, doi: 10.1016/j.mtadv.2022.100259.
2. A. Quatrano, C. Fontana, F. Rubino, N. Cappetti, and P. Carlone, “Analysis of the influence of inner morphology on blood flow in 3D-printed bone scaffolds,” Procedia CIRP, vol. 110, no. C, pp. 226–231, 2022, doi: 10.1016/j.procir.2022.06.041.
3. Y. Miao et al., “Black phosphorus nanosheets-enabled DNA hydrogel integrating 3D-printed scaffold for promoting vascularized bone regeneration,” Bioactive Materials, vol. 21, no. July 2022, pp. 97–109, 2023, doi: 10.1016/j.bioactmat.2022.08.005.
4. G. Belgheisi, M. Haghbin Nazarpak, and M. Solati-Hashjin, “Fabrication and evaluation of combined 3D printed/pamidronate-layered double hydroxides enriched electrospun scaffolds for bone tissue engineering applications,” Applied Clay Science, vol. 225, no. April, p. 106538, 2022, doi: 10.1016/j.clay.2022.106538.
5. S. Aghajanpour et al., “Impact of oxygen-calcium-generating and bone morphogenetic protein-2 nanoparticles on survival and differentiation of bone marrow-derived mesenchymal stem cells in the 3D bio-printed scaffold,” Colloids and Surfaces B: Biointerfaces, vol. 216, no. January, p. 112581, 2022, doi: 10.1016/j.colsurfb.2022.112581.
6. S. Erzengin, E. Guler, E. Eser, E. B. Polat, O. Gunduz, and M. E. Cam, “In vitro and in vivo evaluation of 3D printed sodium alginate/polyethylene glycol scaffolds for sublingual delivery of insulin: Preparation, characterization, and pharmacokinetics,” International Journal of Biological Macromolecules, vol. 204, no. January, pp. 429–440, 2022, doi: 10.1016/j.ijbiomac.2022.02.030.
7. S. Chen, Y. Shi, Y. Luo, and J. Ma, “Layer-by-layer coated porous 3D printed hydroxyapatite composite scaffolds for controlled drug delivery,” Colloids and Surfaces B: Biointerfaces, vol. 179, no. March, pp. 121–127, 2019, doi: 10.1016/j.colsurfb.2019.03.063.
8. J. Yang et al., “Localized delivery of FTY-720 from 3D printed cell-laden gelatin/silk fibroin composite scaffolds for enhanced vascularized bone regeneration,” Smart Materials in Medicine, vol. 3, no. January, pp. 217–229, 2022, doi: 10.1016/j.smaim.2022.01.007.
9. Z. Wang, C. Liu, B. Chen, and Y. Luo, “Magnetically-driven drug and cell on demand release system using 3D printed alginate based hollow fiber scaffolds,” International Journal of Biological Macromolecules, vol. 168, pp. 38–45, 2021, doi: 10.1016/j.ijbiomac.2020.12.023.
10. D. Kim, Y. Wu, and Y. K. Oh, “On-demand delivery of protein drug from 3D-printed implants,” Journal of Controlled Release, vol. 349, no. June, pp. 133–142, 2022, doi: 10.1016/j.jconrel.2022.06.047.
11. X. Farto-Vaamonde, L. Diaz-Gomez, A. Parga, A. Otero, A. Concheiro, and C. Alvarez-Lorenzo, “Perimeter and carvacrol-loading regulate angiogenesis and biofilm growth in 3D printed PLA scaffolds,” Journal of Controlled Release, vol. 352, no. July, pp. 776–792, 2022, doi: 10.1016/j.jconrel.2022.10.060.
12. S. E. Herold et al., “Biomedical Engineering Advances Release kinetics of metronidazole from 3D printed silicone scaffolds for sustained application to the female reproductive tract,” Biomedical Engineering Advances, vol. 5, no. October 2022, p. 100078, 2023, doi: 10.1016/j.bea.2023.100078.
13. M. Goswami, R. Sadasivam, and G. Packirisamy, “Viability studies of hydrogel contact lens on a 3D printed platform as ocular drug delivery carrier for diabetic retinopathy,” Materials Letters, vol. 333, no. December 2022, p. 133636, 2023, doi: 10.1016/j.matlet.2022.133636.
14. Y.-Q. Xue, Y.-C. Zhang, Y.-B. Zhang, and J.-Y. Wang, “Zein-based 3D tubular constructs with tunable porosity for 3D cell culture and drug delivery,” Biomedical Engineering Advances, vol. 5, no. July 2022, p. 100059, 2023, doi: 10.1016/j.bea.2022.100059.
15. L. Diaz-Gomez et al., “3D printed carboxymethyl cellulose scaffolds for autologous growth factors delivery in wound healing,” Carbohydrate Polymers, vol. 278, p. 118924, 2022, doi: 10.1016/j.carbpol.2021.118924.
16. Y.-J. Jeong et al., “3D-printed cardiovascular polymer scaffold reinforced by functional nanofiber additives for tunable mechanical strength and controlled drug release,” Chemical Engineering Journal, vol. 454, no. P2, p. 140118, 2023, doi: 10.1016/j.cej.2022.140118.
17. W. Gao et al., “3D-printed hydroxyapatite (HA) scaffolds combined with exos from BMSCs cultured in 3D HA scaffolds to repair bone defects,” Composites Part B: Engineering, vol. 247, no. June, p. 110315, 2022, doi: 10.1016/j.compositesb.2022.110315.
18. Y. Wang et al., “3D-printed composite scaffold with gradient structure and programmed biomolecule delivery to guide stem cell behavior for osteochondral regeneration,” Biomaterials Advances, vol. 140, no. July, p. 213067, 2022, doi: 10.1016/j.bioadv.2022.213067.
19. X. Zhang et al., “3D printed hydrogel/bioceramics core/shell scaffold with NIR-II triggered drug release for chemo-photothermal therapy of bone tumors and enhanced bone repair,” Chemical Engineering Journal, vol. 461, no. December 2022, p. 141855, 2023, doi: 10.1016/j.cej.2023.141855.
20. C. Liu, Z. Wang, X. Wei, B. Chen, and Y. Luo, “3D printed hydrogel/PCL core/shell fiber scaffolds with NIR-triggered drug release for cancer therapy and wound healing,” Acta Biomaterialia, vol. 131, pp. 314–325, 2021, doi: 10.1016/j.actbio.2021.07.011.
Journal of Polymer and Composites
| Volume | 11 |
| Special Issue | 03 |
| Received | March 6, 2023 |
| Accepted | July 25, 2023 |
| Published | September 3, 2023 |