International Journal of Molecular Biotechnology Cover

International Journal of Molecular Biotechnology

Editors Overview

ijmb maintains an Editorial Board of practicing researchers from around the world, to ensure manuscripts are handled by editors who are experts in the field of study.

Open Access
Special Issue
Topic

The Proteostasis Network’s Various Roles for Small Heat Shock Proteins

Abstract Submission Deadline : November 30, 2024

Manuscript Submission Deadline : December 25, 2024

Special Issue Description

By preventing the buildup of misfolded protein conformers, the protein quality control (PQC) system preserves protein homeostasis. Major tactics used by ATP-dependent proteases and chaperones to degrade and refold substrates make up the proteostasis network. The ATP-independent chaperones known as small heat shock proteins bind to misfolded proteins to stop their uncontrolled aggregation. The conserved-crystallin domain (ACD) is shared by all sHsps, but their N- and C-terminal extensions are varied and generally disordered, giving them functional specialization (NTE, CTE). They are created by numerous, weak contacts between NTE/CTEs and ACD dimers and take the shape of huge, polydisperse oligomers. Due to the enormous heterogeneity of sHsp oligomers and the sequence changes of sHsps, sHsps can perform a variety of functions in the PQC network. When under stress, sHsp oligomers represent dynamic, inactive resting states that are quickly oligomerized and activated, releasing substrate binding sites in NTEs and ACDs. Large sHsp/substrate complexes are typically used to isolate bound substrates. The proteostasis network’s third strategy is represented by the sequestration activity of sHsps. The burden on other PQC components under conditions of acute and ongoing stress is lessened by substrate sequestration. ATP-dependent Hsp70/Hsp100 chaperones can release sequestered substrates and drive them toward refolding pathways, or they can sort them for degradation by autophagic pathways.

Keywords

Homeostasis, ATP-independent, Proteostasis, Autophagic pathways, Polydisperse oligomers

Manuscript Submission information

Manuscripts should be submitted online via the manuscript Engine. Once you register on APID, click here to go to the submission form. Manuscripts can be submitted until the deadline.
All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the email address:[email protected] for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a Double-blind peer-review process. A guide for authors and other relevant information for the submission of manuscripts is available on the Instructions for Authors page.

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International Journal of Molecular Biotechnology

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