Harnessing The Healing Potential Of “Khamira Abresham Hakim Arshad Wala” In The Management Of Different Health Conditions

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Year : April 1, 2024 at 12:01 pm | [if 1553 equals=””] Volume : [else] Volume :[/if 1553] | [if 424 equals=”Regular Issue”]Issue[/if 424][if 424 equals=”Special Issue”]Special Issue[/if 424] [if 424 equals=”Conference”][/if 424] : | Page : –

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    S. Saleemunnisa Yousuff, Asma RA Chaudhary, Asma Malik Azmi, Asif Ali Chaudhary, Fouzia Farooqui

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  1. Assistant Professor, Professor, Professor, Assistant Professor, Associate Professor, Dept of Tahaffuzi wa Samaji Tib, ZVM Unani Medical College and Hospital, Pune, Dept of Ilmul Qabalat wa Amraz e Niswan, ZVM Unani Medical College and Hospital, Pune, Dept of Kulliyat, ZVM Unani Medical College and Hospital, Pune, Dept. of Moalijat, Anjuman-I-Islam’s Dr M.I.J.T Tibbia Unani Medical College and Haji A.R Kalsekar Tibbia Hospital, Mumbai, Dept of Ilaj bit tadbeer, ZVM Unani Medical College and Hospital, Pune, Maharashtra, Maharashtra, Maharashtra, Maharashtra, Maharashtra, India, India, India, India, India
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Abstract

nKhamira Abresham Hakim Arshad Wala (KAHAW) is a potent Unani remedy that plays a vital role in fortifying the body’s vital organs and efficiently reducing free radicals by enhancing levels of antioxidant enzymes. The term ‘Khamira’ originated from the Unani system of medicine and was first introduced by the esteemed Hakeem during the Mughal period. This preparation involves incorporating herbal drugs into a base (Qiwam) containing sugar or honey, resulting in a squashy consistency. KAHAW is widely utilized in preventing ischemic heart diseases and managing various neurodegenerative disorders. Its remarkable properties help maintain healthy blood pressure and promote optimal blood flow. Moreover, it aids in fortifying the brain and liver during convalescence periods and offers relief from the adverse effects of diseases like measles, chickenpox, and smallpox. In the modern era of advanced medicine, KAHAW continues to play a pivotal role in healthcare due to its antioxidant and anti-inflammatory characteristics. Studies have shown its potential in reducing the risk of myocardial infarction and providing significant neuroprotection against cognitive impairments and neurodegeneration. For generations, this traditional medicine has been utilized to efficiently treat a wide spectrum of health conditions. The review article extensively examines the medicinal significance of Khamira Abresham Hakim Arshad Wala (KAHAW), highlighting its remarkable antioxidant and anti-inflammatory properties. These properties have been found to be associated with reduced instances of myocardial infarction, indicating its potential as a heart-protective agent. Moreover, KAHAW exhibits significant neuroprotective effects, guarding against cognitive impairments and neurodegeneration. Furthermore, the article sheds light on the traditional use of KAHAW in treating a diverse range of ailments.

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Keywords: Khamira, KAHAW, Free radicals, Antioxidant, Neuroprotective, Myocardial infarction.

n[if 424 equals=”Regular Issue”][This article belongs to Research & Reviews : A Journal of Unani, Siddha and Homeopathy(rrjoush)]

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[/if 424][if 424 equals=”Special Issue”][This article belongs to Special Issue under section in Research & Reviews : A Journal of Unani, Siddha and Homeopathy(rrjoush)][/if 424][if 424 equals=”Conference”]This article belongs to Conference [/if 424]

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How to cite this article: S. Saleemunnisa Yousuff, Asma RA Chaudhary, Asma Malik Azmi, Asif Ali Chaudhary, Fouzia Farooqui Harnessing The Healing Potential Of “Khamira Abresham Hakim Arshad Wala” In The Management Of Different Health Conditions rrjoush ; :-

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How to cite this URL: S. Saleemunnisa Yousuff, Asma RA Chaudhary, Asma Malik Azmi, Asif Ali Chaudhary, Fouzia Farooqui Harnessing The Healing Potential Of “Khamira Abresham Hakim Arshad Wala” In The Management Of Different Health Conditions rrjoush {cited };:-. Available from: https://journals.stmjournals.com/rrjoush/article=/view=0

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References

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  1. Rahman SZ. History of Science, Philosophy and Culture in Indian Civilization. 2001, 298-325pp
  2. Goyal S, Siddiqui MK, et al. Cardioprotective effect of ‘Khamira Abresham Hakim Arshad Wala’ a unani formulation in isoproterenol-induced myocardial necrosis in rats. Exp Toxicol Pathol 2010; 62(1): 61-74pp
  3. Kabeer U. Bayaaze-e-Kabeer. Daftarul Miyah, Billimaran New Delhi. 1951, 66–68pp
  4. Deshaprabhu SB. The wealth of India. Publications and Information Directorate, Council of Scientific and Industrial Research (CSIR), New Delhi. 1982, 202–440pp
  5. Safiuddin H. Unani Adviya Mafarruda, VIII ed. Tariki Urdu Bureau, R.K. Puram, New Delhi. 1999, 65–294pp
  6. Prince PS, Suman S, et al. Vaithianathan M. Cardio- protective effect of ‘Marutham’ a polyherbal formulation on isoproterenol induced myocardial infarction in Wistar rats. Fitoterapia 2008; 79(6): 433–38pp
  7. Yousuf S, Salim S, Ahmad M, Ahmad AS, Ansari MA, Islam F. Protective effect of Khamira Abresham Uood Mastagiwala against free radical induced damage in focal cerebral ischemia. J Ethnopharmacol 2005; 99(2): 170–84pp
  8. Khan MB, Hoda MN, Yousuf S, et al. Prevention of cognitive impairments and neurodegeneration by Khamira Abresham Hakim Arshad Wala. J Ethnopharmacol 2006; 108(1): 68–73pp
  9. Nazmi AS, Ahmad SJ, Rashikh A, et al. Protective effects of ‘Khamira Abresham Hakim Arshad Wala’ a Unani formulation against doxorubicin –induced cardiotoxicity and nephrotoxicity. Toxicol Mech Methods. 2011; 21(1): 41pp
  10. Akizu N, Cantagrel V, Schroth, et al. AMPD2 regulates GTP synthesis and is mutated in a potentially-treatable neurodegenerative brainstem disorder. Cell 2013; 154(3): 505-17pp
  11. Ajitha M, Rajnarayana K. Role of oxygen free radicals in human diseases. Indian Drugs 2001; 38(11): 545–54pp
  12. Rekha PS, Kuttan G, et al. Antioxidant activity of brahma rasayana. Indian J Exp Biol 2001; 39(5): 447–52pp
  13. Moreira PI, Smith MA, et al. Oxidative stress and neurodegeneration. Anna N Y Acad Sci 2005; 1043: 545-52pp
  14. Olanow CW. A radical hypothesis for neurodegeneration. Trends Neurosci 1993; 16(11): 439-44.
  15. Salim S, Ahmad M, et al. Protective effect of Nardostachys jatamansi in rat cerebral ischemia. Pharmacol Biochem Behav 2003; 74(2): 481–86pp
  16. Blokland A, Jolles J. Spatial learning deficit and reduced hippocampal ChAT activity in rats after an ICV injection of streptozotocin. Pharmacol Biochem Behav 1993; 44(2): 491–94pp
  17. Lannert H, Hoyer S. Intracerebroventricular administration of streptozotocin causes long-term diminutions in learning and memory abilities and in cerebral energy metabolism in adult rats. Behav Neurosci 1998; 112(5): 1199–1208pp
  18. Kerr JS, Adriaanse BA, et al. Mitophagy and Alzheimer’s Disease: Cellular and Molecular Mechanisms. Trends Neurosci 2017; 40(3): 151–66pp
  19. Sharma M, Gupta YK. Intracerebroventricular injection of streptozotocin in rats produces both oxidative stress in the brain and cognitive impairment. Life Science 2001; 68(9): 1021–29pp
  20. Baydas G, Sonkaya E, et al. Novel role for gabapentin in neuroprotection of central nervous system in streptozotocine induced diabetic rats. Acta Pharmacol Sin 2005; 26(4): 417–22pp
  21. Xuejiang W, Magara T, Konishi T. Prevention and repair of cerebral ischemia-reperfusuion injury by Chinese herbal medicine, shengmai san, in rats. Free Radic Res 1999; 31(5): 449–55pp
  22. Shah ZA, Vohora SB. Antioxidant/restorative effects of calcined gold preparations used in Indian systems of medicine against global and focal models of ischemia. Pharmacol Toxicol 2002; 90(5): 254-59pp
  23. Ahmad M, Saleem S, et al. Ginkgo biloba affords dose-dependent protection against 6-hydroxydopamine-induced parkinsonism in rats: neurobehavioural, neurochemical and immunohistochemical evidences. J Neurochem 2005; 93(1): 94–104pp
  24. Vajda FJ. Neuroprotection and neurodegenerative disease. J Clin Neurosci 2002; 9(1): 4–8pp
  25. Izarra A, Moscoso I, et al. MiR-133a enhances the protective capacity of cardiac progenitors’ cells after myocardial infarction. Stem Cell Reports 2014; 3(6): 1029-42pp
  26. De Bono DP, Boon NA. Diseases of the cardiovascular system. In: Edwards CRW, Boucheir IAS, editors. David- son’s principles and practice and medicine. Hong Kong: Churchill Livingstone. 1992, p. 249–340pp
  27. Kilgore KS, Lucchesi BR. Reperfusion injury after myocardial infarction: the role of free radicals and the inflammatory response. Clin Biochem 1993; 26(5): 359–70pp
  28. Wu JR, Song EK, Moser DK, et al. Racial differences in dietary antioxidant intake and cardiac event-free survival in patients with heart failure. Eur J Cardiovasc Nurs 2018; 17(4): 305–13pp
  29. Paul S, Das S, Tanvir EM, et al. Protective effects of ethanolic peel and pulp extracts of Citrus macroptera fruit against isoproterenol-induced myocardial infarction in rats. Biomed Pharmacother 2017; 94: 256–64pp
  30. Rathore N, John S, et al. Lipid peroxidation and antioxidant enzymes in isoproterenol induced oxidative stress in rat tissues. Pharmacol Res 1998; 38(4): 297–303pp
  31. Zhou R, Xu Q, Zheng P, et al. Cardioprotective effect of fluvastatin on isoproterenol- induced myocardial infarction in rat. Eur J Pharmacol 2008; 586(1-3): 244–50pp
  32. Banerjee SK, Sood S, et al. Chronic oral administration of raw garlic protects against isoproterenol-induced myocardial necrosis in rat. Comp Biochem Physiol C Toxicol Pharmacol 2003; 136(4): 377–86pp
  33. Gupta SK, Mohanty I, et al. Cardioprotection from ischemia and reperfusion injury by Withania somnifera: a hemodynamic, biochemical and histopathological assessment. Mol Cell Biochem 2004; 260(1-2): 39 47pp
  34. Rajadurai M, Stanely Mainzen Prince P. Preventive effect of naringin on lipid peroxides and antioxidants in isoproterenol-induced cardiotoxicity in Wistar rats: biochemical and histopathological evidences. Toxicology 2006; 228(2-3): 259–68pp
  35. Nirmala C, Puvanakrishnan R. Protective role of curcumin against isoproterenol induced myocardial infarction in rats. Mol Cell Biochem 1996; 159(2): 85–93pp
  36. Devika PT, Stanely Mainzen Prince P. Protective effect of (-)- epigallocatechin-gallate (EGCG) on lipid peroxide metabolism in isoproterenol induced myocardial infarction in male Wistar rats: a histopathological study. Biomed Pharmacother 2008; 62(10): 701–8pp
  37. Nepal S, Sharma AK, et al. Abresham ameliorates dyslipidemia, hepatic steatosis and hypertension in high-fat diet fed rats by repressing oxidative stress, TNF-α and normalizing NO production. Exp Toxicol Pathol 2012; 64(7-8): 705-12pp
  38. Nazmi AS, Ahmad SJ, et al. Protective effects of ‘Khamira Abresham Hakim Arshad Wala’ a Unani formulation against doxorubicin –induced cardiotoxicity and nephrotoxicity. Toxicol Mech Methods 2011; 21(1): 41-47pp
  39. Abdel-Wahhab MA, Aly SE. Antioxidant property of Nigella sativa (black cumin) and Syzygium aromaticum (clove) in rats during aflatoxicosis. J Appl Toxicol 2005; 25(3): 218–23pp
  40. Sengul M, Yildiz H, et al. Total phenolic content, antioxidant and antimicrobial activities of some medicinal plants. Pak J Pharm Sci 2009; 22(1): 102–6pp
  41. Subashini R, Yogeeta S, Gnanapragasam A, et al. Protective effect of Nardostachys jatamansi on oxidative injury and cellular abnormalities during doxorubicin-induced cardiac damage in rats. J Pharm Pharmacol 2006; 58(2): 257–62pp
  42. Lyle N, Bhattacharyya D, Sur TK, et al. Stress modulating antioxidant effect of Nardostachys jatamansi. Indian J Biochem Biophys 2009; 46(1): 93–98pp
  43. Abdelwahed A, Bouhlel I, Skandrani I. Study of antimutagenic and antioxidant activities of gallic acid and 1,2,3,4,6-pentagalloylglucose from Pistacia lentiscus. Confirmation by microarray expression profiling. Chem Biol Interact 2007; 165(1): 1–13pp
  44. Davidson MH, Maki KC, et al. Effects of consumption of pomegranate juice on carotid intima-media thickness in men and women at moderate risk for coronary heart disease. Am J Cardiol 2009; 104(7): 936–42pp
  45. Kishore RK, Sudhakar D, Parthasarathy PR. Embryo protective effect of pomegranate (Punica granatum L.) fruit extract in adriamycin-induced oxidative stress. Indian J Biochem Biophys 2009; 46(1): 106–111pp
  46. Dash R, Acharya C, Bindu PC, et al. Antioxidant potential of silk protein sericin against hydrogen peroxide-induced oxidative stress in skin fibroblasts. BMB Rep 2008; 41(3): 236–41.
  47. Singal PK, Deally CM, Weinberg LE. Subcellular effects of adriamycin in the heart: a concise review. J Mol Cell Cardiol 1987; 19(8): 817–28pp
  48. Yin X, Wu H, Chen Y, et al. Induction of antioxidants by adriamycin in mouse heart. Biochem Pharmacol 1998; 56(1): 87–93pp
  49. Chularojmontri L, Wattanapitayakul SK, et al. Antioxidative and cardioprotective effects of Phyllanthus urinaria L. on doxorubicin-induced cardiotoxicity. Biol Pharm Bull 2005; 28(7): 1165–71pp
  50. Wattanapitayakul SK, Chularojmontri L, et al. Screening of antioxidants from medicinal plants for cardioprotective effect against doxorubicin toxicity. Basic Clin Pharmacol Toxicol 2005; 96(1): 80–87pp
  51. Elberry AA, Abdel-Naim AB, et al. Cranberry (Vaccinium macrocarpon) protects against doxorubicin-induced cardiotoxicity in rats. Food Chem Toxicol 2010; 48(5): 1178–84pp

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[if 424 not_equal=””][else]Ahead of Print[/if 424] Subscription Review Article

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Volume
[if 424 equals=”Regular Issue”]Issue[/if 424][if 424 equals=”Special Issue”]Special Issue[/if 424] [if 424 equals=”Conference”][/if 424]
Received August 17, 2023
Accepted October 25, 2023
Published

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