A Case Report of Advanced Periampullary Carcinoma: Palliative Chemotherapy Following Whipple’s Surgery

Year : 2024 | Volume :13 | Issue : 01 | Page : 1-6
By

Zaid Khan

Ramya CV

Mekkanti Manasa Rekha

Abstract

This case report delves into the complex management of a 60-year-old female patient diagnosed with Stage 4 periampullary carcinoma, encompassing the pancreatic head. Presenting with difficulty in eating, diagnostic investigations, including ERCP, confirmed the diagnosis, leading to Whipple’s surgery. Postoperatively, liver metastasis was identified, prompting palliative intervention through stenting and the initiation of a GEMOX chemotherapy regimen. The patient responded favorably to the initial chemotherapy cycle, leading to a planned four-cycle course. Notable laboratory abnormalities included elevated liver enzymes. The multidisciplinary approach involved medical oncology, surgery, and supportive care teams, focusing on symptom amelioration and optimizing the patient’s overall quality of life. Despite generally low survival rates for periampullary carcinoma, the positive response to palliative chemotherapy was evident during follow-up, emphasizing the evolving nature of treatment strategies. This case underscores the imperative of expeditious diagnosis and tailored interventions, highlighting the crucial role of palliative chemotherapy in improving patient outcomes. Regular surveillance, symptom management, and comprehensive supportive care collectively contributed to an enhanced quality of life for the patient throughout the chemotherapy follow-up period. The report contributes to academic understanding, emphasizing the multidisciplinary approach’s significance in addressing the complexities of periampullary carcinoma management. Discussion highlights the significance of a multidisciplinary approach in addressing periampullary carcinoma complexities. The case underscores the need for expeditious diagnosis and tailored treatment strategies. Despite generally low overall survival rates for periampullary carcinoma, the positive response to palliative chemotherapy and its impact on the patient’s quality of life were evident during follow-up appointments. The report contributes to the academic understanding of periampullary carcinoma management, emphasizing the crucial role of palliative chemotherapy in enhancing patient outcomes

Keywords: Periampullary carcinoma, Whipple’s surgery, Palliative chemotherapy, Liver metastasis, Endoscopic Retrograde Cholangiopancreatography (ERCP).

[This article belongs to Research & Reviews: Journal of Oncology and Hematology(rrjooh)]

How to cite this article: Zaid Khan, Ramya CV, Mekkanti Manasa Rekha. A Case Report of Advanced Periampullary Carcinoma: Palliative Chemotherapy Following Whipple’s Surgery. Research & Reviews: Journal of Oncology and Hematology. 2024; 13(01):1-6.
How to cite this URL: Zaid Khan, Ramya CV, Mekkanti Manasa Rekha. A Case Report of Advanced Periampullary Carcinoma: Palliative Chemotherapy Following Whipple’s Surgery. Research & Reviews: Journal of Oncology and Hematology. 2024; 13(01):1-6. Available from: https://journals.stmjournals.com/rrjooh/article=2024/view=132433


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Regular Issue Subscription Review Article
Volume 13
Issue 01
Received January 19, 2024
Accepted January 25, 2024
Published February 5, 2024
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