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- Lecturer, Rajiv Gandhi university of health science & Indian nursing council, Karnataka, India
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Abstract
nMarchiafava-Bignami syndrome (MBS) is a rare neurological disorder characterized by demyelination and necrosis of the corpus callosum, which is the main bundle of nerve fibers connecting the two hemispheres of the brain. MBS primarily affects individuals with chronic alcoholism, although cases unrelated to alcohol consumption have also been reported. The corpus callosum is affected in almost a pathognomonic way. The clinical presentation is based on neurological impairment, motor abnormalities, seizures, behavioral changes, and, in severe cases, coma. The diagnosis of MBS involves a combination of clinical assessment, neurological examinations, neuroimaging studies (such as magnetic resonance imaging), and, in some cases, biopsy can be done to assess necrosis, degeneration and gliosis. Management of MBS focuses on addressing underlying causes, providing supportive care, and managing symptoms. This includes alcohol cessation, nutritional support, seizure management, symptomatic treatment, rehabilitation therapies, and psychosocial support. However, the prognosis for MBS is generally poor, with a high mortality rate. Collaboration with the healthcare team and ensuring continuity of care are essential for providing comprehensive and coordinated nursing care for individuals with MBS.
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Keywords: Corpus callosum, hemisphere, demyelination, gliosis, syndrome
n[if 424 equals=”Regular Issue”][This article belongs to Research & Reviews: A Journal of Neuroscience(rrjons)]
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| Volume | 14 | |
| [if 424 equals=”Regular Issue”]Issue[/if 424][if 424 equals=”Special Issue”]Special Issue[/if 424] [if 424 equals=”Conference”][/if 424] | 01 | |
| Received | February 19, 2024 | |
| Accepted | February 22, 2024 | |
| Published | April 19, 2024 |
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