Revolutionizing Drug Delivery: Recent Advances in Pharmaceutical Dosage Forms

Year : 2024 | Volume :13 | Issue : 01 | Page : 77-89
By

Srinatha N

Zaid Khan

  1. Researcher Aditya Bangalore Institute of Pharmacy Education and Research Karnataka India
  2. Researcher Aditya Bangalore Institute of Pharmacy Education and Research Karnataka India

Abstract

Recent advances in pharmaceutical dosage forms revolutionize drug delivery, prioritizing targeted therapy and patient well-being. Enhanced drug carriers address complex medical challenges, from high-grade gliomas to ocular drug delivery, maximizing therapeutic efficacy while minimizing adverse effects. Traditional dosage forms like tablets and capsules undergo meticulous formulation and manufacturing processes, integrating Quality by Design principles for consistent product quality. Liquid formulations encounter stability challenges, necessitating rigorous stability testing and pH monitoring. Topical formulations, including creams, ointments, and patches, optimize drug absorption and retention, while advanced systems like nanotechnology-based delivery offer precise targeting and reduced toxicity. Biodegradable systems and personalized drug delivery represent groundbreaking advancements facilitated by the convergence of 3D printing and pharmacogenomics. This synergy allows for the customization of treatments to suit the unique biological profiles of individual patients, thereby significantly enhancing treatment outcomes and patient adherence. Regulatory oversight and comprehensive safety assessments play pivotal roles in ensuring the effectiveness and safety of these innovative drug delivery technologies, instilling confidence in both healthcare providers and patients alike. Moreover, the economic ramifications of such advancements are profound, with potential cost savings and improved resource allocation. Looking ahead, emerging trends like immune checkpoint therapy and lipid-based nano-drug delivery promise to further revolutionize personalized medicine, offering new avenues for precise and targeted therapeutic interventions. Together, these developments herald a promising era characterized by unparalleled precision, efficacy, and patient-centric care in the field of drug delivery.

Keywords: Pharmaceutical dosage forms, Drug delivery, Targeted therapy, Nanotechnology-based delivery, Personalized drug delivery, Immune checkpoint therapy.

[This article belongs to Research & Reviews : Journal of Medical Science and Technology(rrjomst)]

How to cite this article: Srinatha N, Zaid Khan. Revolutionizing Drug Delivery: Recent Advances in Pharmaceutical Dosage Forms. Research & Reviews : Journal of Medical Science and Technology. 2024; 13(01):77-89.
How to cite this URL: Srinatha N, Zaid Khan. Revolutionizing Drug Delivery: Recent Advances in Pharmaceutical Dosage Forms. Research & Reviews : Journal of Medical Science and Technology. 2024; 13(01):77-89. Available from: https://journals.stmjournals.com/rrjomst/article=2024/view=143355


References

  1. Hauck, Margarethe, et al. “Localized drug delivery systems in high‐grade glioma therapy—from construction to application.” Advanced Therapeutics 5.8 (2022): 2200013.
  2. Sapowadia, Avin, et al. “Biomaterial Drug Delivery Systems for Prominent Ocular Diseases.” Pharmaceutics 15.7 (2023): 1959.
  3. Goel, Vasudha, et al. “Adverse events and complications associated with intrathecal drug delivery systems: insights from the manufacturer and user facility device experience (MAUDE) database.” Neuromodulation: Technology at the Neural Interface 24.7 (2021): 1181-1189.
  4. Kubelt, Carolin, et al. “Establishment of a Rodent Glioblastoma Partial Resection Model for Chemotherapy by Local Drug Carriers—Sharing Experience.” Biomedicines 11.6 (2023): 1518.
  5. Burdina, Olga B., and Olga G. Olekhnovich. “DENOMINATION OF DOSAGE FORMS IN RUSSIA: DEVELOPMENT OF THE TERMS.” Perm University Herald. Russian & Foreign Philology/Vestnik Permskogo Universiteta. Rossijskaa i Zarubeznaa Filolgia 13.1 (2021).
  6. Janczura, Magdalena, Szymon Sip, and Judyta Cielecka-Piontek. “The development of innovative dosage forms of the fixed-dose combination of active pharmaceutical ingredients.” Pharmaceutics 14.4 (2022): 834.
  7. Kawish, Syed M., et al. “Additive Manufacturing and Printing Approaches for the Development of Pharmaceutical Dosage Forms with Improved Biopharmaceutical Attributes.” Current Drug Metabolism 23.8 (2022): 616-629.
  8. Ozalp, Yildiz, et al. “Design and Development of Oxyclozanide Chewable Tablet Formulation Employing Quality by Design Approach.” Indian Journal of Pharmaceutical Education & Research 57 (2023).
  9. Waman, Ravi, et al. “QbD Approach in Formulation Design and Evaluation of Metformin HCl Tablet.”
  10. Mehetre, Gautam D., Rameshwar S. Cheke, and Vinayak N. Shrikhande. “Formulation and in-vitro evaluation of enteric coated tablet incorporating rabeprazole.” Journal of Drug Delivery and Therapeutics 10.2-s (2020): 50-57.
  11. Demir, Ersin, and Hulya Silah. “Development of a new analytical method for determination of veterinary drug oxyclozanide by electrochemical sensor and its application to pharmaceutical formulation.” Chemosensors 8.2 (2020): 25.
  12. Shete, Nikhil Arun, et al. “Optimization of Process Parameters for Formulation of Fluvastatin Tablet by Using Dry Granulation Method.” Journal of Drug Delivery and Therapeutics5-s (2020): 97-107.
  13. Kaur, Gurpreet, D. B. Sridhar, and Manoj Gera. “Optimization of Roll Compaction/Dry Granulation (Rcdg) Process for Poorly Flowable Antiviral Formulation.” Am J Pharmtech Res 2 (2012): 2249-3387.
  14. 14, Hwang, Richard, and Robert M. Noack. “Application of design of experiments to pharmaceutical formulation development.” International Journal of Experimental Design and Process Optimisation 2.1 (2011): 58-65.
  15. Kalmer, Ramin Ramezani, et al. “Industrial Manufacture of Enteric Hard Capsules Using Novel Formulations Based on Hypromellose Phthalate/Gelatin and Investigation of Pantoprazole Release.” ACS omega 8.12 (2023): 11293-11303.
  16. Reddy, M. Sunitha, and Anusha Kunduru. “FORMULATION AND IN-VITRO EVALUATION OF GLIBENCLAMIDE DRY EMULSION IN VEGETARIAN CAPSULES.” INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 4.11 (2017): 3869-3873.
  17. Nie, Lei, et al. “Optimization of a coupling process for insulin degludec according to a Quality by Design (QbD) paradigm.” AAPS PharmSciTech 19 (2018): 2185-2194.
  18. Reddy, M., and M. Banu. FORMULATION AND IN-VITRO EVALUATION OF FENOFIBRATE DRY EMULSION IN HARD VEGETARIAN CAPSULES. 2018, semanticscholar.org/paper/FORMULATION-AND-IN-VITRO-EVALUATION-OF-FENOFIBRATE-Reddy-Banu/a448d104f0117b81bc2e66fe9d71906f392505bd.
  19. Reddy, Madadi Sunitha, and Sai Tanmayee. “FORMULATION AND IN-VITRO EVALUATION OF DRY EMULSION OF MEFENAMIC ACID IN HARD VEGETARIAN CAPSULES.” INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH 9.9 (2018): 3985-3992.
  20. Glass, Beverley D., and Alison Haywood. “Stability considerations in liquid dosage forms extemporaneously prepared from commercially available products.” J Pharm Pharm Sci 9.3 (2006): 398-426.
  21. Haywood, Alison, and Beverley Dawn Glass. “Liquid dosage forms extemporaneously prepared from commercially available products–considering new evidence on stability.” Journal of Pharmacy & Pharmaceutical Sciences 16.3 (2013): 441-455.
  22. Lam, Masha SH. “Extemporaneous compounding of oral liquid dosage formulations and alternative drug delivery methods for anticancer drugs.” Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 31.2 (2011): 164-192.
  23. Jîtcă, Carmen-Maria, et al. “Stability of Oral Liquid Dosage Forms in Pediatric Cardiology: A Prerequisite for Patient’s Safety—A Narrative Review.” Pharmaceutics 15.4 (2023): 1306.
  24. Silva, Márcio Robert Mattos da, et al. “Preparation of extemporaneous oral liquid in the hospital pharmacy.” Brazilian Journal of Pharmaceutical Sciences 56 (2020).
  25. Gillium, Charlotte, et al. “Stability of Extemporaneously Prepared Acetazolamide Oral Suspensions at Two Temperatures.” The Journal of Pediatric Pharmacology and Therapeutics 25.8 (2020): 723-729.
  26. Friciu, Mihaela, et al. “Stability of diazoxide in extemporaneously compounded oral suspensions.” PLoS One 11.10 (2016): e0164577.
  27. Friciu, Mihaela, V. Gaëlle Roullin, and Grégoire Leclair. “Stability of gabapentin in extemporaneously compounded oral suspensions.” PLoS One 12.4 (2017): e0175208.
  28. Casneuf, J., et al. “Oral Thrush in Children Treated with Miconazole Gel Die Behandlung der oralen Candidose bei Kindern mit Miconazol‐Gel.” Mycoses 23.2 (1980): 75-78.
  29. Li, Peng, et al. “Development of Bioadhesive Transdermal Patches of Bupivacaine for the Enhancement of Anaesthetic Effect: Study in Rat Model.” Journal of Biomaterials and Tissue Engineering 12.11 (2022): 2201-2207.
  30. MITTAL, R., and R. BEE. “A REVIEW: MICROEMULSION-BASED POLYMER MATRIX TRANSDERMAL PATCH FOR THE TREATMENT OF INFLAMMATION.” Journal of Pharmaceutical Negative Results (2022): 580-591.
  31. Parhi, Rabinarayan, et al. “Novel penetration enhancers for skin applications: a review.” Current Drug Delivery 9.2 (2012): 219-230.
  32. de Paula, Eneida, et al. “Drug delivery systems for local anesthetics.” Recent patents on drug delivery & formulation 4.1 (2010): 23-34.
  33. Xu, Yi. “Nanomaterials used in cancer treatment based on drug delivery system.” Third International Conference on Biological Engineering and Medical Science (ICBioMed2023). Vol. 12924. SPIE, 2024.
  34. Jahangirian, Hossein, et al. “A review of drug delivery systems based on nanotechnology and green chemistry: green nanomedicine.” International journal of nanomedicine (2017): 2957-2978.
  35. Ma, Zhe, et al. “Traditional Chinese medicine-combination therapies utilizing nanotechnology-based targeted delivery systems: a new strategy for antitumor treatment.” International journal of nanomedicine (2019): 2029-2053.
  36. Rawal, Meghana, Amit Singh, and Mansoor M. Amiji. “Quality-by-design concepts to improve nanotechnology-based drug development.” Pharmaceutical research 36 (2019): 1-20.
  37. Pozharov, Vitaly P., and Tamara Minko. “Nanotechnology-Based RNA Vaccines: Fundamentals, Advantages and Challenges.” Pharmaceutics 15.1 (2023): 194.
  38. Pothupitiya, Jinal U., Christy Zheng, and W. Mark Saltzman. “Synthetic biodegradable polyesters for implantable controlled-release devices.” Expert Opinion on Drug Delivery 19.10 (2022): 1351-1364.
  39. Żółtowska, K., et al. “Development of biodegradable polyesters with various microstructures for highly controlled release of epirubicin and cyclophosphamide.” European Journal of Pharmaceutical Sciences 96 (2017): 440-448.
  40. MITTAL, R., and R. BEE. “A REVIEW: MICROEMULSION-BASED POLYMER MATRIX TRANSDERMAL PATCH FOR THE TREATMENT OF INFLAMMATION.” Journal of Pharmaceutical Negative Results (2022): 580-591.
  41. Alexander, Amit, et al. “Approaches for breaking the barriers of drug permeation through transdermal drug delivery.” Journal of Controlled Release 164.1 (2012): 26-40.
  42. De Santis, Michele, and Ilaria Cacciotti. “Wireless implantable and biodegradable sensors for postsurgery monitoring: Current status and future perspectives.” Nanotechnology 31.25 (2020): 252001.
  43. Park, Jongsung, et al. “A wireless pressure sensor integrated with a biodegradable polymer stent for biomedical applications.” Sensors 16.6 (2016): 809.
  44. Misra, Shashi Kiran, and Kamla Pathak. “Targeted drug delivery approaches for the management of tumors.” Tumor Discovery 2.3 (2023): 1356.
  45. Singh, Amrita, et al. “Ligand-mediated Targeted Drug Delivery Approaches against Hepatocellular Carcinoma.” Current Cancer Drug Targets 23.11 (2023): 879-888.
  46. Meng, Jianing, Vivek Agrahari, and Ibrahima Youm. “Advances in targeted drug delivery approaches for the central nervous system tumors: the inspiration of nanobiotechnology.” Journal of Neuroimmune Pharmacology 12 (2017): 84-98.
  47. Khan, Tanzeel, et al. “Mitochondrial Dysfunction: Pathophysiology and Mitochondria-Targeted Drug Delivery Approaches.” Pharmaceutics 14.12 (2022): 2657.
  48. Shah, Viral, and Pratiksha Kochar. “Brain cancer: implication to disease, therapeutic strategies and tumor targeted drug delivery approaches.” Recent patents on anti-cancer drug discovery 13.1 (2018): 70-85.
  49. Willemen, Niels GA, et al. “From oral formulations to drug-eluting implants: Using 3D and 4D printing to develop drug delivery systems and personalized medicine.” Bio-Design and Manufacturing (2022): 1-22.
  50. Basa, Bálint, et al. “The Application of 3D Printing in the Formulation of Personalized Drug Delivery Systems.” Acta Pharmaceutica Hungarica 91.3-4 (2021): 179-180.
  51. Zhang, Jiaxiang, et al. “Pharmaceutical additive manufacturing: a novel tool for complex and personalized drug delivery systems.” AAPS PharmSciTech 19 (2018): 3388-3402.
  52. Raijada, Dhara, et al. “Integration of personalized drug delivery systems into digital health.” Advanced drug delivery reviews 176 (2021): 113857.
  53. Govender, Rydvikha, et al. “Therapy for the individual: Towards patient integration into the manufacturing and provision of pharmaceuticals.” European Journal of Pharmaceutics and Biopharmaceutics 149 (2020): 58-76.
  54. Csóka, Ildikó, et al. “Regulatory considerations, challenges and risk-based approach in nanomedicine development.” Current Medicinal Chemistry 28.36 (2021): 7461-7476.
  55. Mühlebach, Stefan. “Regulatory challenges of nanomedicines and their follow-on versions: a generic or similar approach?.” Advanced drug delivery reviews 131 (2018): 122-131.
  56. Taha, Maie S., et al. “Critical quality attributes in the development of therapeutic nanomedicines toward clinical translation.” Drug Delivery and Translational Research 10 (2020): 766-790.
  57. Mhetre, Rani M., et al. “Liposome: An advanced pharmaceutical carrier in novel drug delivery system.” International Journal of Science and Research Archive 10.2 (2023): 874-894.
  58. Chien, Yie W. “Novel drug delivery systems.” Drugs and the pharmaceutical sciences 50 (1992).
  59. Dhoundiyal, Shivang, Aditya Sharma, and Md Aftab Alam. “Fiber Technology in Drug Delivery and Pharmaceuticals.” Current Drug Delivery (2024).
  60. Mehta, Prina, et al. “Recent applications of electrical, centrifugal, and pressurised emerging technologies for fibrous structure engineering in drug delivery, regenerative medicine and theranostics.” Advanced drug delivery reviews 175 (2021): 113823.
  61. Rizeq, Balsam R., et al. “Synthesis, bioapplications, and toxicity evaluation of chitosan-based nanoparticles.” International journal of molecular sciences 20.22 (2019): 5776.
  62. Ishihara, Jun. “Abstract IA011: Engineered IL-12 delivery to the tumor matrix to achieve enhanced efficacy and safety in multiple advanced tumors.” Molecular Cancer Therapeutics 22.12_Supplement (2023): IA011-IA011.
  63. Liu, D., et al. “Biocompatibility of porous silicon for biomedical applications.” Porous silicon for biomedical applications. Woodhead Publishing, 2014. 129-181.
  64. Gonzalez, José Antonio, et al. “First-in-human administration of CEB-01, a novel drug delivery implant matrix, in patients with recurrent or locally advanced retroperitoneal soft tissue sarcoma (RPS) after surgery: Preliminary safety and pharmacokinetics report.” (2021): 11554-11554.
  65. Mosallam, Shaimaa, Rofida Albash, and Manar Adel Abdelbari. “Advanced vesicular systems for antifungal drug delivery.” AAPS PharmSciTech 23.6 (2022): 206.
  66. Nirale, Prabhuti, et al. “Liquid Filled Hard Shell Capsules: Current Drug Delivery Influencing Pharmaceutical Technology.” Current Drug Delivery 19.2 (2022): 238-249.
  67. Ma, Jia-Hua, et al. “A review on liquid-filled hard gelatin capsules.” Zhongguo Zhong yao za zhi= Zhongguo Zhongyao Zazhi= China Journal of Chinese Materia Medica 33.5 (2008): 602-605.
  68. Pearson, Steven. “Early experience with health technology assessment of gene therapies in the United States: pricing and paying for cures.” Seminar Briefing. No. 002112. Office of Health Economics, 2019.
  69. Iskrov, Georgi, Georgi Vasilev, and Rumen Stefanov. “What could gene therapies learn from orphan drugs’ post-regulatory approval access in the EU?.” Expert Opinion on Orphan Drugs 7.9 (2019): 407-414.
  70. Friedman, Jed. Evidence for combating malaria. No. 75728. The World Bank, 2010.
  71. Ronquest, Naoko A., et al. “Quantifying the Value of Introducing an Oral Drug Delivery Option for Edaravone: A Review of Analyses Evaluating the Economic Impact of Oral versus Intravenous Formulations.” ClinicoEconomics and Outcomes Research (2022): 499-511.
  72. Balogun, Obe Destiny, et al. “Innovations in drug delivery systems: A review of the pharmacist’s role in enhancing efficacy and patient compliance.” (2023).
  73. Wang, Zhenzhen, and Yan Yang. “Application of 3D printing in implantable medical devices.” BioMed Research International 2021 (2021).
  74. Sun, Qian, et al. “Immune checkpoint therapy for solid tumours: clinical dilemmas and future trends.” Signal Transduction and Targeted Therapy 8.1 (2023): 320.
  75. Singh, Siddharth, and Rajendra Awasthi. “Breakthroughs and bottlenecks of psoriasis therapy: Emerging trends and advances in lipid based nano-drug delivery platforms for dermal and transdermal drug delivery.” Journal of Drug Delivery Science and Technology (2023): 104548.
  76. Patil, Tulshidas S., et al. “Recent Advancements in Topical Anti-Psoriatic Nanostructured Lipid Carrier-Based Drug Delivery.” International Journal of Molecular Sciences 24.3 (2023): 2978.
  77. Hamidi, Esma, et al. “An overview on current trends and future outlook of hydrogels in drug delivery.” Sigma: Journal of Engineering & Natural Sciences/Mühendislik ve Fen Bilimleri Dergisi 41.5 (2023).
  78. Vashist, Arti, et al. “Recent advances in hydrogel based drug delivery systems for the human body.” Journal of Materials Chemistry B 2.2 (2014): 147-166.
  79. Mumtaz, Nazish, et al. “Nanomaterials for Targeted Drug Delivery through Skin to Treat Various Diseases: Recent Trends and Future Perspective.” Journal of Chemistry 2023 (2023).
  80. Zeb, Alam, et al. “Potential of nanoparticulate carriers for improved drug delivery via skin.” Journal of pharmaceutical investigation 49 (2019): 485-517.
  81. Basak, Ankita, et al. “Current trends and future perspectives of natural polymer loaded nanoparticle based drug delivery system for the management of inflammatory bowel disease.” Journal of Applied Pharmaceutical Research 11.4 (2023): 01-09.
  82. Mertins, Omar, Patrick D. Mathews, and Angelina Angelova. “Advances in the design of ph-sensitive cubosome liquid crystalline nanocarriers for drug delivery applications.” Nanomaterials 10.5 (2020): 963.
Regular Issue Subscription Review Article
Volume 13
Issue 01
Received March 6, 2024
Accepted March 10, 2024
Published April 15, 2024
Views: 44