The Relationship Between HbA1c and Inflammatory Markers in Acute Ischemic Stroke with and without Diabetes Mellitus

Year : 2024 | Volume :13 | Issue : 01 | Page : 57-66
By

Leena C.O

Mahendra Kumar Varma

Mathew John

Harisuthan T

  1. PhD Scholar Nims college of Paramedical technology, Nims University Rajasthan India
  2. Principal NIMS University Rajasthan India
  3. Scientist C Jubilee Mission Medical College and Research Institute Kerala India
  4. Assistant Professor Jubilee Mission Medical College and Research Institute Kerala India

Abstract

Background: Diabetes mellitus (DM) is a prominent risk factor for acute ischemic stroke (AIS), contributing significantly to morbidity and mortality worldwide. Although inflammatory markers like neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and C-reactive protein (CRP) are recognized as playing a role in the development of acute ischemic stroke (AIS), their association with diabetes mellitus (DM) in individuals affected by AIS remains uncertain. This study seeks to investigate the differences in inflammatory markers between AIS patients with and without DM, and to conduct a comparative analysis of these markers between the two groups. Methodology: The blood was collected from the participants for biochemical and hematological analysis such as CRP, HbA1c and Complete blood count for the quantitation of NLR and PLR. Results: Comparisons between AIS patients with and without diabetes patients revealed statistically significant differences in CRP levels (p <0.001), HbA1c (p < 0.001) but not in NLR (p = 0.811) or PLR (p = 0.630). The correlation analysis revealed a significant relationship between CRP and HbA1c; no significant correlation was observed between NLR and HbA1c and PLR and HbA1c in either group. Conclusion: The findings suggest that AIS patients with DM tend to have higher CRP levels than those without DM. This indicated that CRP could be an influencing inflammatory marker in DM that triggers the occurrence of AIS. The positive correlation between CRP and HbA1c in AIS with and without DM revealed that both DM and AIS shared common risk factors leading to the pathophysiology.

Keywords: HbA1c, Acute Ischemic stroke, Diabetes Mellitus, Hyperglycemia, C-reactive protein (CRP).

[This article belongs to Research & Reviews : Journal of Medical Science and Technology(rrjomst)]

How to cite this article: Leena C.O, Mahendra Kumar Varma, Mathew John, Harisuthan T. The Relationship Between HbA1c and Inflammatory Markers in Acute Ischemic Stroke with and without Diabetes Mellitus. Research & Reviews : Journal of Medical Science and Technology. 2024; 13(01):57-66.
How to cite this URL: Leena C.O, Mahendra Kumar Varma, Mathew John, Harisuthan T. The Relationship Between HbA1c and Inflammatory Markers in Acute Ischemic Stroke with and without Diabetes Mellitus. Research & Reviews : Journal of Medical Science and Technology. 2024; 13(01):57-66. Available from: https://journals.stmjournals.com/rrjomst/article=2024/view=143014


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Regular Issue Subscription Review Article
Volume 13
Issue 01
Received March 14, 2024
Accepted March 18, 2024
Published April 12, 2024
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