Protective Effects of Phellinus linteus Polysaccharides Against Radiation-Induced Hematopoietic Damage in Bone Marrow of Mice

Year : 2024 | Volume :14 | Issue : 01 | Page : 12-17
By

    Hye-Song Kim

  1. Mok-Ran Jon

  2. Won-Song Paek

  1. Researcher, Pyongyang University of Medical Sciences, Pyongyang, Korea
  2. Researcher, Pyongyang University of Medical Sciences, Pyongyang, Korea
  3. Researcher, Pyongyang University of Medical Sciences, Pyongyang, Korea

Abstract

Chemotherapy and radiation therapy, which are standard methods of treatment for various cancers, often result in suppression of hematopoiesis accompanied by reduction in the number of hematopoietic stem cells and their progeny. We investigated a clinically potential use of Phellinus linteus polysaccharide in the treatment of various cytopenias induced by radiotherapy. Mice were administered Phellinus linteus polysaccharide orally at a dosage of 100 mg/kg once daily for + consecutive days, either prior to (pre-treatment) or following gamma-irradiation (therapy). Those receiving pre-treatment exhibited reduced sensitivity to radiation. After 10 days following irradiation, there was a decline in the levels of red blood cells, white blood cells, and platelets. Nonetheless, the count in the group pre-treated with Phellinus linteus polysaccharide was elevated in comparison to the control group. All blood cells increased significantly as compared to control (P<0.05) after 20 days of irradiation. The number of bone marrow cells and spleen in mice treated with Phellinus linteus polysaccharide had significantly increased after radiation as compared to control (P0.05). The results of the present experimental study showed that Phellinus linteus polysaccharide can accelerate restoration of radiation-induced hematopoietic damage in bone marrow and spleen of mice. Additional research is required before considering its application in safeguarding humans against ionizing radiation, particularly in the context of treating cancer patients undergoing chemotherapy and radiotherapy.

Keywords: chemotherapy, radiation therapy, hematopoietic stem cells, Phellinus linteus polysaccharide, Gamma-irradiation, red blood cells, cancer treatment

[This article belongs to Research & Reviews: A Journal of Medicine(rrjom)]

How to cite this article: Hye-Song Kim, Mok-Ran Jon, Won-Song Paek.Protective Effects of Phellinus linteus Polysaccharides Against Radiation-Induced Hematopoietic Damage in Bone Marrow of Mice.Research & Reviews: A Journal of Medicine.2024; 14(01):12-17.
How to cite this URL: Hye-Song Kim, Mok-Ran Jon, Won-Song Paek , Protective Effects of Phellinus linteus Polysaccharides Against Radiation-Induced Hematopoietic Damage in Bone Marrow of Mice rrjom 2024 {cited 2024 Apr 18};14:12-17. Available from: https://journals.stmjournals.com/rrjom/article=2024/view=143621


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Regular Issue Subscription Original Research
Volume 14
Issue 01
Received May 15, 2023
Accepted February 14, 2024
Published April 18, 2024
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