Tarang Gupta
Sumer Singh
- Research Scholar Department of Life Science, Singhania University, Pacheri Bari, Jhunjhunu Rajasthan India
- Additional Professor Department of Life Science, Singhania University, Pacheri Bari, Jhunjhunu Rajasthan India
Abstract
Introduction: Preeclampsia (PE) is a major obstetric problem contributing considerably to maternal and prenatal morbidity and mortality worldwide. Preeclampsia varies in incidence in India from 5% to 15%. The role of this hematological parameter in clinical assessment, differential diagnosis, and prognosis evaluation of PE remains unclear. Thus, the purpose of the current review was to investigate the RDW in preeclampsia, analyze its importance for early diagnosis, severity assessment, and prognosis, and establish the RDW cutoff value. Methods: A total of 71 studies were initially retrieved from databases. A total of 38 studies were examined after duplicates were eliminated. Out of those, fourteen papers were eventually included in the qualitative and quantitative analysis after meeting the inclusion criteria. The specifics of the chosen publications from hospital settings across the globe between 2013 and 2023.Results: The review included fourteen papers that met the inclusion criteria. Each of the fourteen studies had excellent quality. Four (29%) of the eligible studies were carried out in Turkey and four (29%) from India, respectively. Each of China, Nigeria, Sudan, Japan, Iraq, and Indonesia conducted one study (7%).There were 1809 controls and 1024 cases (preeclampsia) out of a total of 2833 individuals. There were 16 to 136 cases (PE) for every research, while there were 20 to 911 controls. Three studies gave the variance and median, which were converted to the mean (SD) using the recommended procedure. When comparing women with preeclampsia to controls, the mean (SD) of the RDW level was considerably higher [15.73 (2.23) % vs. 14.03 (1.68) %, P < 0.001]. 1.7 was the mean difference. Consequently, the model of continuous random effect was applied. Nine studies compared the RDW level in mild (N = 317) and severe (N = 305) instances of preeclampsia. Conclusion: The association between RDW and preeclampsia, particularly its diagnostic significance in severe cases, is compelling, it's important to note that RDW should not be used in isolation for diagnosis or risk stratification.
Keywords: Preeclampsia Patients, Red Cell, PubMed, MEDLINE, Google Scholar
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Research & Reviews : A Journal of Life Sciences
| Volume | |
| Received | March 6, 2024 |
| Accepted | March 27, 2024 |
| Published | March 30, 2024 |