Section Cutting in Histopathology: An Update

Year : 2024 | Volume :14 | Issue : 01 | Page : 29-34

Hamza Abdul Rahman

Ajit Pal Singh

  1. Student Sharda School of Allied Health Sciences Uttar Pradesh India
  2. Assistant Professor Sharda School of Allied Health Sciences Uttar Pradesh India


Histopathology is the microscopic examination of tissues to diagnose and study diseases, more significantly the diagnosis of cancer. It plays a pivotal role in modern medicine, serving as the gold standard for definitive diagnosis in a wide range of conditions. Through meticulous analysis of tissue morphology (structure) and cellular characteristics, histopathology provides crucial information for disease classification, staging, and guiding patient management. In the world of histopathology, where microscopic details hold the key to diagnosing diseases, section cutting plays an unassuming yet critical role. Imagine a pathologist trying to decipher a complex puzzle from a bulky, opaque object. Section cutting transforms that object into a series of transparent, ultra-thin slices, revealing the intricate cellular architecture and hidden abnormalities within the tissue. This seemingly simple process is vital because it allows for optimal visualization. Sections with a precise thickness (typically 3–10 µm) enable light to penetrate the tissue effectively, revealing cellular and structural features under a microscope. Thicker sections would obscure vital information. Additionally, sectioning ensures a representative sampling of the entire tissue, capturing any uneven disease distribution. This is crucial as some areas may harbor the key to diagnosis. Furthermore, thin sections facilitate staining, which highlights different cellular components for clear and interpretable images. Finally, high-quality sections can be preserved for advanced techniques like immunohistochemistry. In essence, section cutting acts as the gateway to unlocking the secrets within a tissue sample. Without it, pathologists would be left with a limited view, potentially leading to missed diagnoses or inaccurate interpretations. Therefore, section cutting remains an irreplaceable cornerstone of histopathological examination.

Keywords: Microtome, analysis, diagnosis, cellular, sections

[This article belongs to Research & Reviews: A Journal of Health Professions(rrjohp)]

How to cite this article: Hamza Abdul Rahman, Ajit Pal Singh. Section Cutting in Histopathology: An Update. Research & Reviews: A Journal of Health Professions. 2024; 14(01):29-34.
How to cite this URL: Hamza Abdul Rahman, Ajit Pal Singh. Section Cutting in Histopathology: An Update. Research & Reviews: A Journal of Health Professions. 2024; 14(01):29-34. Available from:


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Regular Issue Subscription Review Article
Volume 14
Issue 01
Received March 11, 2024
Accepted March 18, 2024
Published April 23, 2024