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Hamza Abdul Rahman, Ajit Pal Singh
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- Student, Assistant Professor, Sharda School of Allied Health Sciences, Sharda School of Allied Health Sciences, Uttar Pradesh, Uttar Pradesh, India, India
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Abstract
nHistopathology is the microscopic examination of tissues to diagnose and study diseases, more significantly the diagnosis of cancer. It plays a pivotal role in modern medicine, serving as the gold standard for definitive diagnosis in a wide range of conditions. Through meticulous analysis of tissue morphology (structure) and cellular characteristics, histopathology provides crucial information for disease classification, staging, and guiding patient management. In the world of histopathology, where microscopic details hold the key to diagnosing diseases, section cutting plays an unassuming yet critical role. Imagine a pathologist trying to decipher a complex puzzle from a bulky, opaque object. Section cutting transforms that object into a series of transparent, ultra-thin slices, revealing the intricate cellular architecture and hidden abnormalities within the tissue. This seemingly simple process is vital because it allows for optimal visualization. Sections with a precise thickness (typically 3–10 µm) enable light to penetrate the tissue effectively, revealing cellular and structural features under a microscope. Thicker sections would obscure vital information. Additionally, sectioning ensures a representative sampling of the entire tissue, capturing any uneven disease distribution. This is crucial as some areas may harbor the key to diagnosis. Furthermore, thin sections facilitate staining, which highlights different cellular components for clear and interpretable images. Finally, high-quality sections can be preserved for advanced techniques like immunohistochemistry. In essence, section cutting acts as the gateway to unlocking the secrets within a tissue sample. Without it, pathologists would be left with a limited view, potentially leading to missed diagnoses or inaccurate interpretations. Therefore, section cutting remains an irreplaceable cornerstone of histopathological examination.
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Keywords: Microtome, analysis, diagnosis, cellular, sections
n[if 424 equals=”Regular Issue”][This article belongs to Research & Reviews: A Journal of Health Professions(rrjohp)]
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References
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- Singh AP, Saxena RA, Saxena A study on the working of blood bank. J Med Health Res. 2022 Jan 10; 7(1): 1–5.
- Singh Ajit Importance of papanicolaou staining in gynecologic cytology. EPRA Int J Multidiscip Res (IJMR). 2022; 8(9): 216–219.
- Litjens G, Sánchez CI, Timofeeva N, Hermsen M, Nagtegaal I, Kovacs I, Hulsbergen-Van De Kaa C, Bult P, Van Ginneken B, Van Der Laak Deep learning as a tool for increased accuracy and efficiency of histopathological diagnosis. Sci Rep. 2016 May 23; 6(1): 26286.
- Ismail SM, Colclough AB, Dinnen JS, Eakins D, Evans DM, Gradwell E, O’Sullivan JP, Summerell JM, Newcombe Observer variation in histopathological diagnosis and grading of cervical intraepithelial neoplasia. Br Med J. 1989 Mar 18; 298(6675): 707–10.
- Van den Bent Interobserver variation of the histopathological diagnosis in clinical trials on glioma: a clinician’s perspective. Acta Neuropathol. 2010 Sep; 120(3): 297–304.
- Singh AP, Saxena R, Saxena Plasma apheresis procedure. EPRA Int J Multidiscip Res (IJMR). 2022 Jul 20; 8(7): 205–18.
- Singh AP, Mouton RJ, Sharma MK, Ihotu-Owoicho When will this pandemic end? A review. J Basic Appl Res Int. 2021 Dec 29; 27(10): 42–45.
- Singh AP, Batra J, Saxena R, Saxena S, Kumar Alarming rise in professional Blood donors and its repercussions. Cardiometry. 2022 Dec; 1(25): 1394–6.
- Batra J, Singh AP, Saxena R, Saxena S, Goyal Blood components and its usage: a clinical insight from diagnostic lens. J Pharm Negat Results. 2022 Oct 12; 13(6): 1747–50.
- Obiajulu CV, Ochanya OE, Singh Adverse reaction after blood donation in blood bank. Int J Pure Med Res. 2022 Oct 1; 7(10):.
- Singh AP, Batra J, Khan SS, Saxena R, Saxena Diagnosis and treatment of Wilson disease: An update. Cardiometry. 2022 Dec; 1(25): 1397–400.
- Singh AP, Saxena R, Saxena S, Batra An Update on Emergency Contraceptives. International Journal of Food and Nutritional Sciences (IJFANS). 2012; 11(2): 65–70.
- Singh Ajit, Heldaus Jerome, Msaki Hemodialysis Complications: A Clinical Insight. Int J All Res Educ Sci Methods. 2023; 11(3): 640–647. 10.56025/IJARESM.2023.11323640.
- Singh Ajit, Saxena Rahul, Saxena An elaborated study on bio-medical waste and its successful administration. Int J Recent Sci Res. 2022; 13(8): 2121–2126. 10.24327/ijrsr.2022.1308.0436.
- Singh Ajit, Batra Jyoti, Saxena Rahul, Saxena Susceptibility to Cervical Cancer: An Overview. Int J Food Sci Nutr. 2022; 11(2): 731–739.
- Singh AP, Saxena RA, Saxena Hemoglobin estimation by using copper sulphate method. Asian J Curr Res. 2022 Jul 13; 7(1): 13–5.
- Singh AP, Saxena RA, Saxena Protocols for blood collection in a blood bank. J Med Health Res. 2022 Sep; 7(2): 16–21.
- Singh AP, Saxena R, Saxena Cytopathology: An Important Aspect of Medical Diagnosis. Res Rev: J Oncol Hematol. 2023; 12(3): 13–18
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Research & Reviews: A Journal of Health Professions
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| Volume | 14 | |
| [if 424 equals=”Regular Issue”]Issue[/if 424][if 424 equals=”Special Issue”]Special Issue[/if 424] [if 424 equals=”Conference”][/if 424] | 01 | |
| Received | March 11, 2024 | |
| Accepted | March 18, 2024 | |
| Published | April 23, 2024 |
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