Advancements in Method Development and Validation for Levocetirizine: A Comprehensive Review

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Year : April 12, 2024 at 4:21 pm | [if 1553 equals=””] Volume :11 [else] Volume :11[/if 1553] | [if 424 equals=”Regular Issue”]Issue[/if 424][if 424 equals=”Special Issue”]Special Issue[/if 424] [if 424 equals=”Conference”][/if 424] : 01 | Page : 15-27

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    Patil Divyashree Kantilal, Amit Kumar R Dhankani, Mansi A Dhankani, S.P. Pawar

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  1. Student, Assistant Professor, Assistant Professor, Principal, P.S.G.V.P., Mandal’s College of Pharmacy Shahada,, P.S.G.V.P., Mandal’s College of Pharmacy Shahada,, P.S.G.V.P., Mandal’s College of Pharmacy Shahada,, P.S.G.V.P., Mandal’s College of Pharmacy Shahada,, Maharashtra, Maharastra, Maharastra, Maharastra, India, India, India, India
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Abstract

nThis review article delves into the intricate realm of concurrent estimation of multiple compounds, with a specific emphasis on Levocetirizine and its related substances. It looks into how to improve analytical process specificity by using reverse phase high-performance liquid chromatography (RP-HPLC) in conjunction with UV detection. The study meticulously explores the intricacies of method development and validation, offering invaluable insights into the realms of precision and accuracy within pharmaceutical analysis. Throughout the discourse, the review sheds light on the nuanced methodologies employed, illustrating their efficacy in concurrently estimating multiple compounds. The emphasis on Levocetirizine and its related substances underscores the relevance and applicability of these findings within pharmaceutical contexts. By scrutinizing the method development and validation processes, the review not only highlights the technical nuances involved but also provides a comprehensive understanding of the underlying principles governing precision and accuracy in analytical procedures. The significance of the findings reverberates within the realm of pharmaceutical analysis, as they underscore the pivotal role of advanced RP-HPLC techniques. Through meticulous experimentation and analysis, the review elucidates the potential of these techniques to enhance specificity, thereby augmenting the reliability and robustness of pharmaceutical analyses. Furthermore, the insights gleaned from the study offer a roadmap for researchers and practitioners seeking to navigate the complexities of concurrent compound estimation. In essence, this review article serves as a cornerstone in the field of pharmaceutical analysis, offering a comprehensive exploration of RPHPLC methodologies for concurrent compound estimation. Its conclusions not only make a substantial contribution to the corpus of current knowledge, but they also highlight how important accuracy and precision are in pharmacological analyses. As such, it provides a seminal reference point for further research and development endeavors within this burgeoning field.

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Keywords: RP-HPLC, Pharmaceutical analysis, Levocetirizine, UV detection, Method development.

n[if 424 equals=”Regular Issue”][This article belongs to Research & Reviews: A Journal of Drug Formulation, Development and Production(rrjodfdp)]

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[/if 424][if 424 equals=”Special Issue”][This article belongs to Special Issue under section in Research & Reviews: A Journal of Drug Formulation, Development and Production(rrjodfdp)][/if 424][if 424 equals=”Conference”]This article belongs to Conference [/if 424]

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How to cite this article: Patil Divyashree Kantilal, Amit Kumar R Dhankani, Mansi A Dhankani, S.P. Pawar Advancements in Method Development and Validation for Levocetirizine: A Comprehensive Review rrjodfdp April 12, 2024; 11:15-27

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How to cite this URL: Patil Divyashree Kantilal, Amit Kumar R Dhankani, Mansi A Dhankani, S.P. Pawar Advancements in Method Development and Validation for Levocetirizine: A Comprehensive Review rrjodfdp April 12, 2024 {cited April 12, 2024};11:15-27. Available from: https://journals.stmjournals.com/rrjodfdp/article=April 12, 2024/view=0

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References

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1.Pathuri R, Muthukumaran M, Krishnamoorthy B, Nishat A. A review on analytical method development and validation of pharmaceutical technology. Journal of Current Pharma Research. 2013;3(2):855..
2.Shivhare, Himani, and Preeti Chincholikar. “analytical chemistry: Overview (Techniques & Applications).” Journal of Pharmaceutical Negative Results (2022): 1364–1373..
3.Panchal, D. M. K., Patel, D., Patel, K., Dalwadi, M., & Upadhyay, U. A review on “high performance thin layer chromatography”. World Journal of Pharmaceutical Research Vol 11, Issue 15, 2022.PP:282–297.
4.Vidushi Y, Meenakshi B, Bharkatiya M. A review on HPLC method development and validation. Res J Life Sci, Bioinform, Pharm Chem Sci. 2017;2(6):178.
5.Rina R, Baile M, Jain AA. Review: Analytical Method Development and Validation. Syst. Rev. Pharm. 2021 Jun 11;12(11):3601–5.
6.Shetgar SS, Ramadevi D, Rao BM, Basavaiah K. RP-UPLC method development and validation for quantitative estimation of levocetirizine in levocetirizine dihydrochloride tablets. IJPSR. 2022;13(2):987–95.
7.Suyash Gupta et al. Method Development and Validation of an RP- HPLC Method for Determination of Levocetirizine, Ijppr.Human, 2022; Vol. 26 (1): PP;147–182.
8.M Prasada Rao*, Analytical Method Development and Validation of Levocetirizine Hydrochloride and Montelukast Sodium in Combined Tablet Dosage Form by RP-HPLC Research, Journal of Pharmaceutical, Biological and Chemical Sciences, (2014)5(6) Page No. 1010–1021.
9.Shetgar SS, Ramadevi D, Rao BM, Basavaiah K., RP-UPLC method development and validation for quantitative estimation of levocetirizine in levocetirizine dihydrochloride tablets. IJPSR. 2022;13(2):987–95.,
10.Biagi M, Vegni AM, Pergoloni S, Butala PM, Little TD. Trace-orthogonal PPM-space time block coding under rate constraints for visible light communication. Journal of lightwave technology. 2014 Dec 31;33(2):481–94.,
11.Kumar S, Gautam D, Talwan P. Method development and validation for the simultaneous estimation of in atorvastatin and fenofibrate bulk and pharmaceutical dosage form by using RP-HPLC method. International Journal of Research in Pharmacy and Chemistry. 2020;10(1).
12.Ali S, Gupta M. Method development and validation for the simultaneous estimation of montelukast sodium and levocetirizine hydrochloride tablet using RP-HPLC. Journal of Pharmaceutical Sciences and Research. 2019 Aug 1;11(8):2998–3000.
13.K. Venila Rani, et al. method development and validation for the simultaneous estimation montelukast and levocetirizine pharmaceutical dosage form by using RP-HPLC, Int J Pharm 2015; 5(2): PP:631–636.
14.Basu A, Basak K, Chakraborty M, Rawat IS. Simultaneous RP-HPLC estimation of Levocetirizine Hydrochloride and Montelukast Sodium in tablet dosage form. International Journal of PharmTech Research. 2011 Jan;3(1):405–10.

15.Sonawane JK, Patil DA, Jadhav BS, Jadhav SL, Patil PB. Stability Indicating RP-HPLC method development and validation for simultaneous quantification of antihistaminic & anti-asthmatic drug in bulk and tablet dosage form. Journal of Pharmaceutical and Biological Sciences. 2020;8(1):12.
16.Reddy KR, Anila P, Rao GS, Ram PS, Jyothi KN, Bhavani KG. Green synthesis, morphological and spectral properties of CdS nanoparticles. Indian Journal of Research in Pharmacy and Biotechnology. 2016 Nov 1;4(6):271.

17.Khatri S, Dhanoriya C, Jain DK. Zika virus (ZIKV) disease: past, present and future. Journal of Drug Delivery and Therapeutics. 2018 Dec 15;8(6–s):320–7.
18.Wichitnithad W, Jithavech P, Sanphanya K, Vicheantawatchai P, Rojsitthisak P. Determination of Levocetirizine in Human Plasma by LC–MS-MS: Validation and Application in a Pharmacokinetic Study. Journal of chromatographic science. 2015 Nov 1;53(10):1663–72.
19.Rajarajana M, Senbagam R, Vijayakumar R, Manikandan V, Balaji S, Vanangamudi G, Thirunarayanan G. Synthesis, spectral studies and antimicrobial activities of some substituted (E)-1-benzylidene-2-(4-bromophenyl) hydrazines. World Scientific News. 2015(3):155–71.
20.Noha S. Rashed*, Ola M. Abdallah and Noha S. Said Analytical Chemistry Department, Faculty of Pharmacy (Girls), Al -Azhar University, Cairo, Egypt., Vol 4, Issue 05, 2015, World Journal of Pharmacy and Pharmaceutical Sciences.
21.Parmar K, Baldania S, Shah D, Chhalotiya U, Parmar N. Development and validation of first-order derivative spectrophotometry for simultaneous determination of levocetirizine dihydrochloride and phenylephrine hydrochloride in pharmaceutical dosage form. International Journal of Spectroscopy. 2013;2013.
22.Chaitanya Prasad MK, Vidyasagar G, Sambasiva Rao KRS, Madhusudhanareddy Induri and Ramanjeneyulu S Journal of Applied Pharmaceutical Science 01 (10); 2011: 95–97
23.Rathore AS, Sathiyanarayanan L, Mahadik KR. Development of validated HPLC and HPTLC methods for simultaneous determination of levocetirizine dihydrochloride and montelukast sodium in bulk drug and pharmaceutical dosage form. Pharmaceutica Analytica Acta. 2010;1(1):1–6.

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[if 424 not_equal=””]Regular Issue[else]Published[/if 424] Subscription Original Research

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Volume 11
[if 424 equals=”Regular Issue”]Issue[/if 424][if 424 equals=”Special Issue”]Special Issue[/if 424] [if 424 equals=”Conference”][/if 424] 01
Received March 14, 2024
Accepted March 27, 2024
Published April 12, 2024

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