Simultaneous Determination And Stability Indicating Method For Telmisartan, Metoprolol Succinate And Cilnidipine In Tablet Dosage Form.

Year : 2024 | Volume :11 | Issue : 01 | Page : –
By

Dr. Bhaveshkumar Patel

  1. Associate Professor K.B. Institute of Pharmaceutical Education and Research Gujarat India

Abstract

There are several medicinal agents are available for antihypertensive activity. Telmisartan, Metoprolol and Cilnidipine are among them. Quantitative and qualitative analysis play a pivot role to safeguard patients. Here, estimation of these drugs was performed by using chromatographic technique RP-HPLC. It was conducted with Phosphate buffer (pH 3.5 ± 0.01): Methanol (50:50 v/v) mobile phase. The system was operated at 1ml/min. Drug volume to system was 20µl. The column as a stationary Phase was C18, Hypersil BDS with 250mm*4.6mm dimension. In experimental section, linearity and range was kept between 20 to 60 µg/ml for Telmisartan, 5 to 15 µg/ml for Cilnidipine and 25 to 75 µg/ml for Metoprolol. The drugs were eluted at 3.4, 4.1 and 11.5 min. for Telmisartan, Metoprolol and Cilnidipine, respectively. Accuracy study was found to be 98.32 to 101.57 % for all three drugs. % RSD value of repeatability study was less than 2 %. The determination of drugs were carried out at 215 nm. The method was also applied to pharmaceutical dosage form. The proposed study was validated by ICH guideline. The proposed study also extended for degradation protocol for all the drugs. The drugs were exposed to various conditions include acidic, basic, oxidation and thermal and photolytic. The force degradation had shown more degradation in oxidative condition, 35.98 % for Telmisartan while 29.07 % and 36.67 % in basic condition for Metoprolol succinate and Cilnidipine, respectively. Very least degradation had been observed in photolytic condition. It was 13.11 %, 14.39 % and 15.25% for Telmisartan, Metoprolol and Cilnidipine, respectively. The validated procedure would have application regarding stability indicating, impurity separation, qualitative and quantitative estimation of Telmisartan, Metoprolol and Cilnidipine in solid dosage form.

Keywords: Telmisartan, Metoprolol, Cilnidipine, HPLC, Validation, Degradation.

[This article belongs to Research & Reviews: A Journal of Drug Design & Discovery(rrjoddd)]

How to cite this article: Dr. Bhaveshkumar Patel. Simultaneous Determination And Stability Indicating Method For Telmisartan, Metoprolol Succinate And Cilnidipine In Tablet Dosage Form.. Research & Reviews: A Journal of Drug Design & Discovery. 2024; 11(01):-.
How to cite this URL: Dr. Bhaveshkumar Patel. Simultaneous Determination And Stability Indicating Method For Telmisartan, Metoprolol Succinate And Cilnidipine In Tablet Dosage Form.. Research & Reviews: A Journal of Drug Design & Discovery. 2024; 11(01):-. Available from: https://journals.stmjournals.com/rrjoddd/article=2024/view=143456





Browse Figures

References

1) Indian Pharmacopoeia , Government of Indian ministry of health and family welfare, Indian Paramacopoeia Commision,Ghaziabad, Volume 3, 2010, pp: 2186,2187.
2). United States Pharmacopoeia 2016-National formulary [USP39 NF 34] Volume II. Rockville, M.D: United States Pharmacopoeial Convention; pp: 6035.
3). British Pharmacopoeia 2014, Volume II, London ,British Pharmacopoeia Commission; pp : 977.
4) Rathod S, Patil P, Waghmare S, Chaudhari P. UV- Spectrophotometric method for Estimation of Telmisartan in Bulk and Tablet Dosage Form. International journal of Pharmaceutical Sciences and Research. 2012; 3(10):3936-3939p.
5) Jadhav A, Tarkase K, Deshpande A. Quantitative Determination of Metoprolol succinate in bulk and tablet Dosage form through comparative study of UV and derivative
Spectroscop. Der Pharmacia Letter. 2012;4(3):763-767p.
6) Jadhav R, Bharad J. Analytical Method Development and Validation of Spectroscopic Method for Estimation of Metoprolol Succinate.Der Pharmacia Lettre. 2017; 9(6): 285-297p.
7) Patel P, Marolia B, Shah S, Shah D. Second Order derivative Spectrophotometric Method for simultaneous Estimation of Telmisartan and Metoprolol in Tablet Dosage Form. International Research Journal of Pharmacy.2012; 3(5): 259-262p.
8) Thapaswini B, Reddy T, Rao U, Ramya S, A Validated RP-HPLC Method for Estimation of Telmisartan and Metoprolol in its Bulk and Pharmaceutical Dosage Forms. International Journal of Biomedical Investigation.2015; 4(8): 2373-2382 p.
9). Alagar M, Spoorthy N, Banji D, Rao K. Simultaneous Estimation of Metoprolol Succinate and Telmisarta in tablet dosage form by RP-HPLC. Journal of Pharmacy Research. 2012; 5(8): ISSN: 4585-4587.
10) Kalshetti M, Kankure S. Development and validation of rp-hplc method for simultaneous estimation of metoprolol, telmisartan and clinidipine in tablet. IJPSR. 2021; 12 (3): 1651-1657p.
11) Jain N, Sharma B, Jain R, Jain D. RP-HPLC Method Development and Validation for Quantitative Estimation of Metoprolol Succinate and Telmisartan in Bulk Drug and Their Dosage Forms. JPBMS. 2012; 24 (24): 102-106p.

12) Rao T, Keerthana H. Simultaneous estimation of cilnidipine and telmisartan by rp-hplc in pharmaceutical dosage form. IJMPR; 2023; 7(11): 27-35p.

13) Desai D, Vashi N, HPTLC Method Development and Validation of Cilnidipine and Metoprolol Succinate in Combined Dosage Form. Pharm Methods. 2016; 7(1): 28-34p.
14) Butle S, Deshpande P. Development and validation of stability-indicating hptlc method for simultaneous determination of telmisartan and cilnidipine in combined tablet dosage form.IJPSDR. 2015; 7(6): 478-483p.


Regular Issue Subscription Original Research
Volume 11
Issue 01
Received April 1, 2024
Accepted April 5, 2024
Published April 15, 2024