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Chhatrapalsinh R. Parmar, Pratiksha N. Patil, Riddhi S.Bhavsar, Rohitkumar D.Shah, Riya A.Rajput
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- Student, Student, Student, Student, Student, Ahinsa Institute of Pharmacy, Ahinsa Institute of Pharmacy, Ahinsa Institute of Pharmacy, Ahinsa Institute of Pharmacy, Ahinsa Institute of Pharmacy, Maharashtra, Maharashtra, Maharashtra, Maharashtra, Maharashtra, India, India, India, India, India
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Abstract
nOne of the most prevalent metabolic disorders is osteoporosis (OP), which primarily affects postmenopausal women and the elderly. It is often associated with gradual loss of bone density, ongoing destruction of bone microstructure and increased risk of osteoporosis. Pharmacotherapy is the primary approach for treating and preventing osteoporosis. But persistent medication therapy invariably results in drug responses and particular adverse effects. Therefore, scientists continue to search for new monomeric compounds from natural plants. Curcumin (CUR), a drug candidate for the treatment of osteoporosis, is a natural phenolic compound with various pharmacological and biological activities such as antioxidant, antiapoptotic, and anti-inflammatory. This connection has been studied for the maintenance of bone health in various models of osteoporosis. We go over preclinical and clinical research on curcumin’s ability to prevent and treat osteoporosis. These results suggest that, if rigorous clinical and clinical studies are conducted, curcumin could be used as a supplement and other medications to heal bones by targeting the standard layers of the osteoporosis process. In addition to providing information for future study and development of curcumin, this article discusses the mechanism of action and therapeutic potential of curcumin in preventing and treating osteoporosis. Contents: The medication curcumin has a wide range of chemical and biological effects.
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Keywords: Osteoporosis (OP), Osteoblast, Osteoclast, Molecular Mechanism, Curcumin (CUR).
n[if 424 equals=”Regular Issue”][This article belongs to Research & Reviews: A Journal of Drug Design & Discovery(rrjoddd)]
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Research & Reviews: A Journal of Drug Design & Discovery
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| Volume | 11 | |
| [if 424 equals=”Regular Issue”]Issue[/if 424][if 424 equals=”Special Issue”]Special Issue[/if 424] [if 424 equals=”Conference”][/if 424] | 01 | |
| Received | March 12, 2024 | |
| Accepted | April 5, 2024 | |
| Published | April 15, 2024 |
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