The Dental Pulp: Vital Core of Tooth Functionality

Year : 2024 | Volume : | : | Page : –
By

Sadhvi Gupta

Charu Gandhi

Hari Narayan

Abstract

Dental pulp, an intricately specialized mesenchymal tissue, possesses limited regenerative capabilities attributable to the unique anatomical arrangement and the post-mitotic nature of odontoblastic cells. The process of complete pulp amputation, subsequent disinfection of the pulp space, and the insertion of synthetic materials results in the substantial loss of dentin, leading to enduring consequences such as a non-vital and structurally weakened tooth.Nevertheless, a beacon of hope emerges in the form of regenerative endodontics, a burgeoning field within modern tissue engineering. This innovative approach has shown considerable promise by harnessing the potential of stem cells in conjunction with scaffolds and responsive molecules. In stark contrast to traditional methods that often result in irreversible damage, regenerative endodontics seeks to stimulate the inherent regenerative capacity of dental pulp, fostering the restoration of both form and function.Through strategic interventions that prioritize the preservation of tooth vitality, regenerative endodontics aims to revolutionize dental care by promoting the regeneration of damaged tissues. This forward-looking paradigm offers a transformative shift from mere restorative practices to regenerative strategies, envisioning a future where compromised teeth can be revitalized through the orchestrated collaboration of biological components. As research in this field advances, the prospect of regenerative endodontics becoming a mainstream therapeutic approach holds the promise of enhancing the longevity and quality of dental treatments

Keywords: Regeneration; Histology of pulp; Vascular supply of pulp; Dental pulp stem cells; Angiogenesis; Scaffolds.

How to cite this article: Sadhvi Gupta, Charu Gandhi, Hari Narayan. The Dental Pulp: Vital Core of Tooth Functionality. Research & Reviews: A Journal of Dentistry. 2024; ():-.
How to cite this URL: Sadhvi Gupta, Charu Gandhi, Hari Narayan. The Dental Pulp: Vital Core of Tooth Functionality. Research & Reviews: A Journal of Dentistry. 2024; ():-. Available from: https://journals.stmjournals.com/rrjod/article=2024/view=137061


References

  1. Trowbridge, H.O. and Kim, S., 1998. Pulp development, structure and function. Pathways of the Pulp. St. Louis: Mosby, 1998386424.
  2. Morse, D.R., 1991. Age-related changes of the dental pulp complex and their relationship to systemic aging. Oral surgery, oral medicine, oral pathology, 72(6), pp.721-745.
  3. Garg, N. and Garg, A., 2010. Textbook of endodontics. Boydell & Brewer Ltd.
  4. Ricucci, D. and Siqueira Jr, J.F., 2010. Fate of the tissue in lateral canals and apical ramifications in response to pathologic conditions and treatment procedures. Journal of endodontics, 36(1), pp.1-15.
  5. Tziafas, D. and Kodonas, K., 2010. Differentiation potential of dental papilla, dental pulp, and apical papilla progenitor cells. Journal of endodontics, 36(5), pp.781-789.
  6. Li, Y., Jacox, L.A., Little, S.H. and Ko, C.C., 2018. Orthodontic tooth movement: The biology and clinical implications. The Kaohsiung journal of medical sciences, 34(4), pp.207-214.
  7. Balic, A., Aguila, H.L., Caimano, M.J., Francone, V.P. and Mina, M., 2010. Characterization of stem and progenitor cells in the dental pulp of erupted and unerupted murine molars. Bone, 46(6), pp.1639-1651.
  8. Sloan, A.J. and Waddington, R.J., 2009. Dental pulp stem cells: what, where, how?. International Journal of Paediatric Dentistry, 19(1), pp.61-70.
  9. Tjäderhane, L., Carrilho, M.R., Breschi, L., Tay, F.R. and Pashley, D.H., 2009. Dentin basic structure and composition—an overview. Endodontic topics, 20(1), pp.3-29.
  10. Ella, B., Sédarat, C., Da Costa Noble, R., Normand, E., Lauverjat, Y., Siberchicot, F., Caix, P. and Zwetyenga, N., 2008. Vascular connections of the lateral wall of the sinus: surgical effect in sinus augmentation. International Journal of Oral & Maxillofacial Implants, 23(6).
  11. Wadu, S.G., Penhall, B. and Townsend, G.C., 1997. Morphological variability of the human inferior alveolar nerve. Clinical Anatomy: The Official Journal of the American Association of Clinical Anatomists and the British Association of Clinical Anatomists, 10(2), pp.82-87.
  12. Jacobsen, P., 2009. Restorative dentistry: an integrated approach. John Wiley & Sons.
  13. Yang, J., Yuan, G. and Chen, Z., 2016. Pulp regeneration: current approaches and future challenges. Frontiers in physiology, 7, p.58.
  14. Yang, J.W., Zhang, Y.F., Wan, C.Y., Sun, Z.Y., Nie, S., Jian, S.J., Zhang, L., Song, G.T. and Chen, Z., 2015. Autophagy in SDF-1α-mediated DPSC migration and pulp regeneration. Biomaterials, 44, pp.11-23.
  15. Zehnder, M., 2006. Root canal irrigants. Journal of endodontics, 32(5), pp.389-398.
  16. Morse, D.R., 1991. Age-related changes of the dental pulp complex and their relationship to systemic aging. Oral surgery, oral medicine, oral pathology, 72(6), pp.721-745.
  17. Peng C, Zhao Y, Wang W, Yang Y, Qin M, Ge L. Histologic Findings of a Human Immature Revascularized/Regenerated Tooth with Symptomatic Irreversible Pulpitis. J Endod. 2017 Jun;43(6):905-909.
  18. Mainkar A, Kim SG. Diagnostic Accuracy of 5 Dental Pulp Tests: A Systematic Review and Meta-analysis. J Endod. 2018 May;44(5):694-702.
  19. Nissan R, Trope M, Zhang CD, Chance B. Dual wavelength spectrophotometry as a diagnostic test of the pulp chamber contents. Oral Surg Oral Med Oral Pathol. 1992 Oct;74(4):508-14.

 


Ahead of Print Subscription Review Article
Volume
Received February 6, 2024
Accepted February 9, 2024
Published March 30, 2024