Mechanism of Action of Essential Oils and their Major Components

Open Access

Year : 2023 | Volume : | : | Page : –
By

Naga Parameswari Mangalagiri

Kavitha Velagapudi

Shravan Kumar Panditi

Naveena Lavanya Latha Jeevigunta

  1. Research Scholar Department of Biotechnology, Krishna University, Machilipatnam, Krishna Andhra Pradesh India
  2. Research Scholar Department of Biotechnology, KrUniversity, Machilipatnam, Krishna Andhra Pradesh India
  3. Research Scholar Department of Biotechnology, KrishnUniversity, Machilipatnam, Krishna Andhra Pradesh India
  4. Assistant Professor & Head (i/C) Department of Biosciences and Biotechnology, Krishna University, Machilipatnam, Krishna Andhra Pradesh India

Abstract

The essential oil of lemongrass, palm rosa and eucalyptus were found to be good antimicrobial agents. To a large extent the results suggest their potential use as chemotherapeutic agents, food preserving agents, and disinfectants. However before considering these compounds as chemotherapeutic agents against human/animal diseases, it is important to study their cytotoxic and mutagenic effects. Studies were then carried to investigate the probable mechanism by which these compounds act against Gram negative (E. coli) and Gram-positive (Staphylococcus aureus) bacteria. The leakage of potassium ions from the cell suspension of bacteria and change in absorption maxima in presence of the test compounds was monitored. The results indicate that, in presence of crude essential oils the leakage of bacterial cellular material was higher than that showed in presence of the individual major components of essential oils, which is due their ability to disrupt the permeability barrier of microbial membrane structures, although the presence of additional mechanisms or targets cannot be ruled out.

Keywords: Plant essential oils, anti bacterial, anti fungal, potassium leakage, absorption maxima

How to cite this article: Naga Parameswari Mangalagiri, Kavitha Velagapudi, Shravan Kumar Panditi, Naveena Lavanya Latha Jeevigunta. Mechanism of Action of Essential Oils and their Major Components. Research & Reviews : Journal of Botany. 2023; ():-.
How to cite this URL: Naga Parameswari Mangalagiri, Kavitha Velagapudi, Shravan Kumar Panditi, Naveena Lavanya Latha Jeevigunta. Mechanism of Action of Essential Oils and their Major Components. Research & Reviews : Journal of Botany. 2023; ():-. Available from: https://journals.stmjournals.com/rrjob/article=2023/view=92109

Full Text PDF Download

References

1. Rotimi Larayetan, Zacchaeus S. Ololade, Oluranti O. Ogunmola, Ayodele Ladokun, “”Phytochemical Constituents, Antioxidant, Cytotoxicity, Antimicrobial, Antitrypanosomal, and Antimalarial Potentials of the Crude Extracts of Callistemon citrinus””, Evidence-Based Complementary and Alternative Medicine, vol. 2019, 14 pages, 2019. https://doi.org/ 10.1155/2019/5410923
2. Recio, M.C., and Rios, J.L. 1989. A review of some antimicrobial compounds isolated from medicinal plants reported in the literature 1978-1988. Phytopathology research. 3: 117-124.
3. Takahashi Y, Nakashima T. Actinomycetes, an Inexhaustible Source of Naturally Occurring Antibiotics. Antibiotics. 2018; 7(2):45. https://doi.org/10.3390/antibiotics7020045
4. Egorov, A. M., Ulyashova, M. M., & Rubtsova, M. Y. (2018). Bacterial Enzymes and Antibiotic Resistance. Actanaturae, 10(4), 33–48.
5. Ameryckx A, Thabault L, Pochet L, Leimanis S, Poupaert JH, Wouters J, Joris B, Van Bambeke F, Frédérick R. 1-(2-Hydroxybenzoyl)-thiosemicarbazides are promising antimicrobial agents targeting d alanine-d-alanine ligase in bacterio. Eur J Med Chem. 2018 Nov 5;159:324-338. doi: 10.1016/j.ejmech.2018.09.067. Epub 2018 Sep 28. PMID: 30300845.
6. Rai, M., Pandit, R., Gaikwad, S., & Kövics, G. (2016). Antimicrobial peptides as natural biopreservative to enhance the shelf-life of food. Journal of food science and technology, 53(9), 3381–3394. https://doi.org/10.1007/s13197-016-2318-5
7. Singh V. P. (2018). Recent approaches in food bio-preservation – a review. Open veterinary journal, 8(1), 104–111. https://doi.org/10.4314 /ovj.v8i1.16
8. Booth, I.R. 1985. Regulation of cytoplasmic pH in bacteria. Microbiol. Rev. 49: 359-378.
9. Poolman, B., Driessen, A.J.M., and Konings, W.N. 1987. Regulation of solute transport in streptococci by external and internal pH values. Microbiological Reviews. 51: 498-508.
10. Alberts B, Johnson A, Lewis J, et al. Molecular Biology of the Cell. 4th edition. New York: Garland Science; 2002. Membrane Proteins. Available from: https://www.ncbi.nlm.nih.gov/books/NBK26878/
11. Davidson, P.M., and Branen, A.L. 1981. Antimicrobial activity of non-halogenated phenolic compounds. J. Food Prot. 44: 623-632.
12. L. De León , L. Moujir. Activity and mechanism of the action of zeylasterone against Bacillus subtilis. Journal of Applied Microbiology, Volume 104, Issue 5May 2008, Pages 1266-1274
13. Liu, D., Ragothama, K.G., Hasegawa, P.M., and Bressan, R.A. 1988. Osmotin over expression in potato delays development of disease symptoms. Proc. Natl. Acad. Sci. USA. 91: 1888.
14. Jingyi Liu, Changling Du, Henry T. Beaman and Mary Beth B. Monroe Characterization of Phenolic Acid Antimicrobial and Antioxidant Structure–Property Relationships. Pharmaceutics 2020, 12, 419; doi:10.3390/pharmaceutics12050419
15. Hugo, W.B., and Bloomfield, S.F. 1971a. Studies on the mode of action of the phenolic antibacterial agent fentichlor against Staphylococcus aureusand Escherichia coli. II. The effects of fentichlor on the bacterial membrane and the cytoplasmic constituents of the cell. J. Appl. Bacteriol. 34(3):569-578.
16. Hugo, W.B., and Bloomfield, S.F. 1971b. Studies on the mode of action of the phenolic antibacterial agent fentichlor against Staphylococcus aureusand Escherichia coli. III. The effect of fentichlor on the metabolic activities of Staphylococcus aureusand Escherichia coli. J. Appl. Bacteriol. 34(3): 579-591.
17. Paul Lee, Joyce D. Linderman, Sheila Smith, Robert J. Brychta, Juan Wang, Christopher Idelson, Rachel M. Perron, Charlotte D. Werner, Giao Q. Phan, Udai S. Kammula, Electron Kebebew, Karel Pacak, Kong Y. Chen, Francesco S. Celi, Irisin and FGF21 Are Cold-Induced Endocrine Activators of Brown Fat Function in Humans, Cell Metabolism, Volume 19, Issue 2, 2014, Pages 302-309, ISSN 1550-4131
18. Chouhan, S., Sharma, K., & Guleria, S. (2017). Antimicrobial Activity of Some Essential Oils- Present Status and Future Perspectives. Medicines (Basel, Switzerland), 4(3), 58. https://doi.org/10.3390/medicines4030058
19. Salmond, C.V., Kroll, R.G., and Booth, I.R. 1984. The effect of food preservatives on pH homeostasis in Escherichia coli. J. Gen. Microbiol. 130:2845-2850.
20. Knobloch, K., Pauli, A., Iberl, B., Weis, N., and Weigand, H. 1988. Antibacterial activity and antifungal properties of essential oil components. Journal of Essential oils Research.1:119-128.
21. Bruno C. Marreiros, Filipa Calisto, Paulo J. Castro, Afonso M. Duarte, Filipa V. Sena, Andreia F. Silva, Filipe M. Sousa, Miguel Teixeira, Patrícia N. Refojo, Manuela M. Pereira, Exploring membrane respiratory chains, Biochimica et Biophysica Acta (BBA) – ioenergetics, Volume 1857, Issue 8, 2016, Pages 1039-1067, ISSN 0005-2728.
22. Han, Y., Sun, Z., & Chen, W. (2019). Antimicrobial Susceptibility and Antibacterial Mechanism of Limonene against Listeria monocytogenes. Molecules (Basel, Switzerland), 25(1), 33. https://doi.org/10.3390/molecules25010033.
23. Ultee, Annemieke & Wells-Bennik, Marjon & Moezelaar, Roy. (2002). The Phenolic Hydroxyl Group of Carvacrol Is Essential for Action against the Food-Borne Pathogen Bacillus cereus.
Applied and environmental microbiology. 68. 1561-8. 10.1128/AEM.68.4.1561-1568.2002.
24. Cristani, Mariateresa & D’Arrigo, Manuela & Mandalari, Giuseppina & Castelli, Francesco & Sarpietro, mariagrazia & Micieli, Dorotea & Venuti, Vincenza & Bisignano, Giuseppe & Saija, Antonella & Trombetta, Domenico. (2007). Interaction of Four Monoterpenes Contained in Essential Oils with Model Membranes: Implications for Their Antibacterial Activity. Journal of agricultural and food chemistry. 55. 6300-8. 10.1021/jf070094x.
25. Nazzaro, F., Fratianni, F., De Martino, L., Coppola, R., & De Feo, V. (2013). Effect of essential oils on pathogenic bacteria. Pharmaceuticals (Basel, Switzerland), 6 (12), 1451–1474. https://doi.org/10.3390 /ph6121451
26. Sikkema, J., de Bont, J.A.M., and Poolman, B. 1995. Mechanisms of membrane toxicity of hydrocarbons. Microbiological Reviews. 59:201-222.
27. Cox, S.D., Mann, C.M., Markham, J.L., Bell, H.C., Gustafson, J.E., Warmington, J.R., and Wyllie, S.G. 2000. The mode of antimicrobial action of the essential oil of Melaleucaalternifolia (Tea tree oil). Journal of Applied Microbiology. 88: 170-175.
28. Zeinab Breijyeh, Buthaina Jubeh and Rafik Karaman Resistance of Gram-Negative Bacteria to Current Antibacterial Agents and Approaches to Resolve It. Molecules 2020, 25, 1340; doi:10.3390/molecules25061340.
29. Heipieper, H.J., Diefenbach, R., and Keweloh, H. 1992. Conversion of cis unsaturated fatty acids to trans, a possible mechanism for the protection of phenol-degrading Pseudomonas putidaP8 from substrate toxicity. Appl. Environ. Microbiol. 58: 1847- 1852.
30. Naga Parameswari Mangalagiri, Shravan Kumar Panditi, Naveena Lavanya Latha Jeevigunta. Antimicrobial activity of essential plant oils and their major components, Heliyon, Volume 7, Issue 4, 2021, e06835, ISSN 2405-8440, https://doi.org/10.1016/j.heliyon.2021.e06835.
31. Yanping Wu, JinrongBai, Kai Zhong, Yina Huang, Huayi Qi, Yan Jiang and Hong Gao Antibacterial Activity and Membrane-Disruptive Mechanism of 3-p-trans-Coumaroyl-2- hydroxyquinic Acid, a Novel Phenolic Compound from Pine Needles of Cedrusdeodara, against Staphylococcus aureus Molecules 2016, 21, 1084; doi:10.3390/molecules21081084.
32. Lopez Romero, Julio & Ríos, Humberto& Borges, Anabela & Simões, Manuel. (2015). Antibacterial Effects and Mode of Action of Selected Essential Oils Components against Escherichia coli and Staphylococcus aureus. Evidence-based Complementary and Alternative Medicine. 2015. 10.1155/2015/795435.
33. Carson, C.F., Mee, B.J., and Riley, T.V. 2002. Mechanism of action of Melaleucaalternifolia (Tea tree oil) on Staphylococcus aureus determined by time-kill, lysis leakage and salt tolerance assays and Electron Microscopy. Antimicrob. Agent Chemothe. 46: 1914-1920.
34. Tagousop, C.N., Tamokou, JdD., Ekom, S.E. et al. Antimicrobial activities of flavonoid glycosides from Graptophyllumgrandulosum and their mechanism of antibacterial action. BMC Complement Altern Med 18, 252 (2018). https://doi.org/10.1186/s12906-018-2321-7.
35. Shabana Bowsiya, Dr. Naveen Kumar Antibacterial Activity of Tea Tree Oil against Clinical Isolates of Staphylococcus aureus Int. J. Pharm. Sci. Rev. Res., 60(2), January – February 2020; Article No. 17, Pages: 102-106.
36. Uribe, S., Ramorez, J., and Pena, A. 1985. Effects of β -pinene on yeast membrane functions. J. Bacteriol. 161: 1195-1200.
37. Perumal, S., Mahmud, R., & Ismail, S. (2017). Mechanism of Action of Isolated Caffeic Acid and Epicatechin 3-gallate from Euphorbia hirta against Pseudomonas aeruginosa. Pharmacognosy magazine, 13 (Suppl 2), S311–S315. https://doi.org/10.4103 /pm.pm_309_15.
38. Breijyeh, Z., Jubeh, B., & Karaman, R. (2020). Resistance of Gram-Negative Bacteria to Current Antibacterial Agents and Approaches to Resolve It. Molecules (Basel, Switzerland), 25(6), 1340. https://doi.org/10.3390/molecules25061340.
39. Mercedes Verdeguer, Adela M. Sánchez-Moreiras and Fabrizio Araniti. Phytotoxic Eects and Mechanism of Action of Essential Oils and Terpenoids. Plants 2020, 9, 1571; doi:10.3390/plants9111571.
40. Othman Leen, Sleiman Ahmad, Abdel-Massih Roula M. Antimicrobial Activity of Polyphenols and Alkaloids in Middle Eastern Plants. Frontiers in Microbiology, 10, 2019, 911 DOI=10.3389/fmicb.2019.00911 ISSN=1664-302X.


Open Access Article
Volume
Received September 16, 2021
Accepted October 29, 2021
Published January 29, 2023