An Optimize Formulation to Synthesis of size Controlled Hydrophobic Starch Acetate Nanoparticles using Box- Behnken Design

Open Access

Year : 2022 | Volume : | Issue : 1 | Page : 33-52
By

    Gaurang Rami

  1. Tanvi Nayak

  2. Jabali J. Vora

  1. Research Scholar, Department of Chemistry, Hemchandracharya North Gujarat University, Gujarat, India
  2. Assistant Professor, Shree Sarvajanik PG Science College, Gujarat, India
  3. Professor, Department of Chemistry, Hemchandracharya North Gujarat University, Gujarat, India

Abstract

The best way to improve the overall performance of native starch is by chemical modification. In recent years, hydrophobically modified starch has attracted considerable attention for the design and manufacture of novel nanoparticulate drug delivery carriers. The purpose of this research was to synthesize hydrophobic starch nanoparticles (NPs) and to optimize process factors through the use of response surface methodology (RSM). The corn starch acetate (CSA) NPs was synthesized using an ultrasonic emulsification solvent evaporation process. The Box-Behnken design (BBD) was used to investigate the effect of process factors on particle size and polydispersity index (PDI) including polymer concentration (A), sonication energy (B) and sonication time (C). For the correlation of the dependent and independent variables, we used mathematical equations and response surface graphs. The predicted minimized particle size (155 nm; 0.132 PDI) under the optimum conditions of the process variables (5mg/ml (A), 100kcal (B) and 30min (C)) were very close to the experimental value (161nm and 0.136 PDI) determined in the batch experiment. XRD analysis revealed that the A-type pattern of corn starch (CS) was completely replaced by the V-type pattern of CSA. The CSA and CSA NPs more thermally stable than the CS were confirmed by TGA analysis. From FE-SEM analysis, the polygonal shape of the CS was changed into a beehive-like structure with uniform porosity and the CSA NPs were seen as uniformly distributed spherically shaped NPs. In pharmaceutical formulation concerns, BBD is an effective design because it permits exploration and selection of the optimal composition with the least number of experiments to achieve a specific goal.

Keywords: Box Behnken design, Corn starch acetate, Nanoparticles, Optimization, Ultrasonication.

[This article belongs to Journal of Polymer and Composites(jopc)]

How to cite this article: Gaurang Rami, Tanvi Nayak, Jabali J. Vora An Optimize Formulation to Synthesis of size Controlled Hydrophobic Starch Acetate Nanoparticles using Box- Behnken Design jopc 2022; 10:33-52
How to cite this URL: Gaurang Rami, Tanvi Nayak, Jabali J. Vora An Optimize Formulation to Synthesis of size Controlled Hydrophobic Starch Acetate Nanoparticles using Box- Behnken Design jopc 2022 {cited 2022 Apr 18};10:33-52. Available from: https://journals.stmjournals.com/jopc/article=2022/view=90161

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References

1. Granqvist, C. G., R. A. Buhrman, J. Wyns, et.al. Far-infrared absorption in ultrafine Al particles. Physical Review Letters. 1976; 37(10): 625.
2. Buzea, Cristina, Ivan I. Pacheco, Kevin Robbie. Nanomaterials and nanoparticles: sources and toxicity. Biointerphases. 2007; 2(4): MR17-MR71.
3. Mahapatro, Anil, Dinesh K. Singh. Biodegradable nanoparticles are excellent vehicle for site directed in-vivo delivery of drugs and vaccines. Journal of nanobiotechnology. 2011; 9(1):55.
4. Yang, Jinlong, Yinjuan Huang, Chunmei Gao, et.al. Fabrication and evaluation of the novel reduction-sensitive starch nanoparticles for controlled drug release. Colloids and Surfaces B: Biointerfaces. 2014; 115: 368-376.
5. Kim, Hee-Young, Sung Soo Park, Seung-Taik Lim. Preparation, characterization and utilization of starch nanoparticles. Colloids and Surfaces B: Biointerfaces. 2015; 126: 607-620.
6. Zhang, Aiping, Zhe Zhang, Fenghua Shi, et.al. Disulfide crosslinked PEGylated starch micelles as efficient intracellular drug delivery platforms. Soft Matter. 2013; 9(7): 2224-2233.
7. Grossman, Richard F., Domasius Nwabunma. Biopolymer nanocomposites: processing, properties, and applications. Vol. 8. John Wiley & Sons; 2013.
8. Chin Suk Fun, Suh Cem Pang, Soon Hiang Tay. Size controlled synthesis of starch nanoparticles by a simple nanoprecipitation method. Carbohydrate Polymers. 2011; 86(4): 1817-1819.
9. Prado, Héctor J., María C. Matulewicz, Pablo R. Bonelli, et.al. Preparation and characterization of a novel starch-based interpolyelectrolyte complex as matrix for controlled drug release. Carbohydrate research. 2009; 344(11): 1325-1331.
10. Han, Fei, Chunmei Gao, Mingzhu Liu. Fabrication and characterization of size-controlled starch-based nanoparticles as hydrophobic drug carriers. Journal of nanoscience and nanotechnology. 2013; 13(10): 6996-7007.
11. Seker, Mahmut, Milford A. Hanna. Cross-linking starch at various moisture contents by phosphate substitution in an extruder. Carbohydrate Polymers. 2005; 59(4): 541-544.
12. Navarchian, Amir H., Amir Sharafi,Roha K. Kermanshahi. Biodegradation study of starch-graft-acrylonitrile copolymer. Journal of Polymers and the Environment. 2013; 21(1): 233-244.
13. Zhou, Jiang, Lili Ren, Jin Tong, et.al. Effect of surface esterification with octenyl succinic anhydride on hydrophilicity of corn starch films. Journal of applied polymer science. 2009; 114(2): 940-947.
14. Wang, Lu-Feng, Si-Yi Pan, et.al. Synthesis and properties of carboxymethyl kudzu root starch. Carbohydrate Polymers. 2010; 80(1): 174-179.
15. N. L. Vanier, E. Da Rosa Zavareze, V. Z. Pinto, et.al. Physicochemical, crystallinity, pasting and morphological properties of bean starch oxidised by different concentrations of sodium hypochlorite. Food Chem. 2012; 131(4): 1255-1262.
16. Chang, Yung-Ho, Jheng-Hua Lin, Cheng-yi Lii. Effect of ethanol concentration on the physicochemical properties of waxy corn starch treated by hydrochloric acid. Carbohydrate Polymers. 2004; 57(1) 89-96.
17. Zhou Y, Meng S, Chen D, et.al. Structure characterization and hypoglycemic effects of dual modified resistant starch from indica rice starch. Carbohydrate polymers. 2014; 103: 81-86.
18. Sweedman MC, Tizzotti MJ, Schäfer C, et.al. Structure and physicochemical properties of octenyl succinic anhydride modified starches: A review. Carbohydrate polymers. 2013; 92(1): 905-920.
19. Singh N, Chawla D, Singh J. Influence of acetic anhydride on physicochemical, morphological and thermal properties of corn and potato starch. Food Chemistry. 2004; 86(4): 601-608.
20. Santayanon R, Wootthikanokkhan J. Modification of cassava starch by using propionic anhydride and properties of the starch-blended polyester polyurethane. Carbohydrate Polymers. 2003; 51(1): 17-24.
21. Winkler H, Vorwerg W, Wetzel H. Synthesis and properties of fatty acid starch esters. Carbohydrate polymers. 2013 ;98(1): 208-216.
22. Najafi SH, Baghaie M, Ashori A. Preparation and characterization of acetylated starch nanoparticles as drug carrier: Ciprofloxacin as a model. International journal of biological macromolecules. 2016; 87:48-54.
23. Paulos G, Mrestani Y, Heyroth F, et.al. Fabrication of acetylated dioscorea starch nanoparticles: Optimization of formulation and process variables. Journal of Drug Delivery Science and Technology. 2016; 31: 83-92.
24. Santander-Ortega MJ, Stauner T, Loretz B, et.al. Nanoparticles made from novel starch derivatives for transdermal drug delivery. Journal of controlled release. 2010 ;141(1):85-92.
25. Chin, Suk Fun, Ain NB Romainor, Suh Cem Pang, et.al. pH‐responsive starch‐citrate nanoparticles for controlled release of paracetamol. Starch‐Stärke. 2019; 71( 9-10): 1800336.
26. Xu, Yue, Wanqiang Ding, Ji Liu, et.al. Preparation and characterization of organic-soluble acetylated starch nanocrystals. Carbohydrate Polymers. 2010; 80(4): 1078-1084.
27. Shi AM, Li D, Wang LJ, et.al. Preparation of starch-based nanoparticles through high-pressure homogenization and miniemulsion cross-linking: Influence of various process parameters on particle size and stability. Carbohydrate Polymers. 2011;83(4):1604-1610.
28. Liu D, Wu Q, Chen H, et.al. Transitional properties of starch colloid with particle size reduction from micro-to nanometer. Journal of Colloid and Interface Science. 2009 Nov 1;339(1):117-124.
29. Song D, Thio YS, Deng Y. Starch nanoparticle formation via reactive extrusion and related mechanism study. Carbohydrate polymers. 2011 Apr 22;85(1):208-214.
30. Lamanna M, Morales NJ, García NL, et.al. Development and characterization of starch nanoparticles by gamma radiation: Potential application as starch matrix filler. Carbohydrate polymers. 2013 ;97(1):90-97.
31. Patel CM, Chakraborty M, Murthy ZV. Fast and scalable preparation of starch nanoparticles by stirred media milling. Advanced Powder Technology. 2016;27(4):1287-1294.
32. Haaj SB, Magnin A, Pétrier C, et.al. Starch nanoparticles formation via high power ultrasonication. Carbohydrate polymers. 2013 Feb 15;92(2):1625-1632.
33. Chang Y, Yan X, Wang Q, et.al. High efficiency and low cost preparation of size controlled starch nanoparticles through ultrasonic treatment and precipitation. Food chemistry. 2017; 227: 369-375.
34. Mujtaba A, Ali M, Kohli K. Statistical optimization and characterization of pH-independent extended-release drug delivery of cefpodoxime proxetil using Box–Behnken design. Chemical engineering research and design. 2014;92(1):156-165.
35. Issa, M.A.; Abidin, Z.Z.; Sobri, S.; et.al. Fabrication, characterization and response surface method optimization for quantum efficiency of fluorescent nitrogen-doped carbon dots obtained from carboxymethylcellulose of oil palms empty fruit bunch. Chin. J. Chem. Eng. 2020; 28: 584–592.
36. Chopra, S.; Motwani, S.K.; Iqbal, Z.; et.al. Optimisation of polyherbal gels for vaginal drug delivery by Box-Behnken statistical design. Eur. J. Pharm. Biopharm. 2007; 67: 120–131
37. Lepeniotis, Stefanos, Bernice I. Feuer. Synthesis of starch acetate: Statistical designed experiments to optimize the reaction conditions. Chemometrics and Intelligent Laboratory Systems. 1997; 36(2): 229-243.
38. Venugopal V, Kumar KJ, Muralidharan S, et.al. Optimization and in-vivo evaluation of isradipine nanoparticles using Box-Behnken design surface response methodology. OpenNano. 2016; 1:1-5.
39. Hoa, Le Thi Mai, Nguyen Tai Chi, Le Huu Nguyen, et.al Preparation and characterisation of nanoparticles containing ketoprofen and acrylic polymers prepared by emulsion solvent evaporation method. Journal of Experimental Nanoscience. 2012; 7(2): 189-197.
40. Najafi, Seyed Heydar Mahmoudi, Maryam Baghaie, et.al. Preparation and characterization of acetylated starch nanoparticles as drug carrier: Ciprofloxacin as a model. International journal of biological macromolecules. 2016; 87: 48-54.
41. Wang, Xu, WenYuan Gao, LiMing Zhang, et.al. Study on the morphology, crystalline structure and thermal properties of yam starch acetates with different degrees of substitution. Science in China Series B: Chemistry. 2008; 51(9): 859-865.
42. Han, Fei, Mingzhu Liu, Honghong Gong, et.al. Synthesis, characterization and functional properties of low substituted acetylated corn starch. International Journal of Biological Macromolecules. 2012; 50(4): 1026-1034.
43. Han, Fei, Chunmei Gao, Mingzhu Liu. Fabrication and characterization of size-controlled starch-based nanoparticles as hydrophobic drug carriers. Journal of nanoscience and nanotechnology. 2013; 13(10): 6996-7007.
44. Minakawa, Alyne FK, Paula CS, et.al. Simple ultrasound method to obtain starch micro-and nanoparticles from cassava, corn and yam starches. Food chemistry. 2019; 283: 11-18.
45. Chang, Yanjiao, Xiaoxia Yan, Qian Wang, et.al. High efficiency and low cost preparation of size controlled starch nanoparticles through ultrasonic treatment and precipitation. Food chemistry. 2017; 227 :369-375.
46. Ding, Yongbo, Jiong Zheng, Xuejuan Xia, et.al. Box–Behnken design for the optimization of nanoscale retrograded starch formation by high-power ultrasonication. LWT-Food Science and Technology. 2016; 67: 206-213.
47. Mainardes, Rubiana M., Raul C. Evangelista. PLGA nanoparticles containing praziquantel: effect of formulation variables on size distribution. International journal of pharmaceutics. 2005; 290(1-2): 137-144.
48. Mathematica. Design Expert Software Version 8.0.7.1. [online]. Available from http://www.statease.com/soft-ftp, (accessed on 15.08.21).


Regular Issue Open Access Article
Volume 10
Issue 1
Received October 6, 2021
Accepted March 12, 2022
Published April 18, 2022