Synthesis, Characterization and Anti-Bacterial Activity of Mono and Binuclear_ed

Open Access

Year : 2023 | Volume : 11 | Special Issue : 02 | Page : 107-120
By

    Esraa S. Mahdi

  1. Master Student, Department of Chemistry, College of Sciences, Al-Nahrain University, Baghdad, Iraq

Abstract

Mixed-ligand complexes of Co(II) and Cr(III) ions were synthesized from the reaction of metals chloride salts with α-amino acid (H2L1) as a primary ligand and 1,10-phenanthroline (L2) as secondary ligand. The ligand 2-(benzo[d]thiazol-2-ylamino)-2-(2-hydroxynaphthalen-1-yl) acetic acid (H2L1) has been synthesized from the condensation reaction of inobenzothiazol with 2-hydroxy-1-naphthaldehyde in the presence of HCN as three components–one pot reaction. H2L1 considered as a tridentate chelater of ONO-coordination binding type toward the metals, while L2 considered as bidentate chelater of NNcoordination binding type toward the metals. The suggested formula for the mononuclear complexes were [Co(L1) (L2) H2O] and [Cr (L1) (L2) Cl], and the formula of the binuclear complexes are: Na2 [Co2 (L1)2 (L2)2 (L3)], and [Cr2 (L1)2 (L2)2 (L3)] where H2L3 = 1,3-diaminopropan which is considered as a bridging ligand or spacer linkage between metals of mononuclear complexes. The obtained compounds were characterized by different spectroscopic techniques like FTIR, 1H-NMR, 13C-NMR,
UV-Vis, TGA, melting point and conductance measurement, and the geometry was found to be a distorted octahedral. In vitro antibacterial activity of the ligands, salts, and metal complexes was tested against two pathogenic bacteria: Pseudomonas (gram negative) and Escherichia coli (gram positive), using the well diffusion method.

Keywords: Mixed-ligand complexes of Co(II) and Cr(III) ions were synthesized from the reaction of metals chloride salts with α-amino acid (H2L1) as a primary ligand and 1,10-phenanthroline (L2) as secondary ligand. The ligand 2-(benzo[d]thiazol-2-ylamino)-2-(2-hydroxynaphthalen-1-yl) acetic acid (H2L1) has been synthesized from the condensation reaction of inobenzothiazol with 2-hydroxy-1-naphthaldehyde in the presence of HCN as three components–one pot reaction.

This article belongs to Special Issue Conference Material Science and Nanotechnology

How to cite this article: Esraa S. Mahdi Synthesis, Characterization and Anti-Bacterial Activity of Mono and Binuclear_ed jopc 2023; 11:107-120
How to cite this URL: Esraa S. Mahdi Synthesis, Characterization and Anti-Bacterial Activity of Mono and Binuclear_ed jopc 2023 {cited 2023 Apr 18};11:107-120. Available from: https://journals.stmjournals.com/jopc/article=2023/view=111892

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Conference Open Access Article
Volume 11
Special Issue 02
Received December 8, 2022
Accepted January 31, 2023
Published April 18, 2023