Open Access
Esraa S. Mahdi
- Master Student Department of Chemistry, College of Sciences, Al-Nahrain University Baghdad Iraq
Abstract
Mixed-ligand complexes of Co(II) and Cr(III) ions were synthesized from the reaction of metals chloride salts with α-amino acid (H2L1) as a primary ligand and 1,10-phenanthroline (L2) as secondary ligand. The ligand 2-(benzo[d]thiazol-2-ylamino)-2-(2-hydroxynaphthalen-1-yl) acetic acid (H2L1) has been synthesized from the condensation reaction of inobenzothiazol with 2-hydroxy-1-naphthaldehyde in the presence of HCN as three components–one pot reaction. H2L1 considered as a tridentate chelater of ONO-coordination binding type toward the metals, while L2 considered as bidentate chelater of NNcoordination binding type toward the metals. The suggested formula for the mononuclear complexes were [Co(L1) (L2) H2O] and [Cr (L1) (L2) Cl], and the formula of the binuclear complexes are: Na2 [Co2 (L1)2 (L2)2 (L3)], and [Cr2 (L1)2 (L2)2 (L3)] where H2L3 = 1,3-diaminopropan which is considered as a bridging ligand or spacer linkage between metals of mononuclear complexes. The obtained compounds were characterized by different spectroscopic techniques like FTIR, 1H-NMR, 13C-NMR,
UV-Vis, TGA, melting point and conductance measurement, and the geometry was found to be a distorted octahedral. In vitro antibacterial activity of the ligands, salts, and metal complexes was tested against two pathogenic bacteria: Pseudomonas (gram negative) and Escherichia coli (gram positive), using the well diffusion method.
Keywords: Mixed-ligand complexes of Co(II) and Cr(III) ions were synthesized from the reaction of metals chloride salts with α-amino acid (H2L1) as a primary ligand and 1,10-phenanthroline (L2) as secondary ligand. The ligand 2-(benzo[d]thiazol-2-ylamino)-2-(2-hydroxynaphthalen-1-yl) acetic acid (H2L1) has been synthesized from the condensation reaction of inobenzothiazol with 2-hydroxy-1-naphthaldehyde in the presence of HCN as three components–one pot reaction.
This article belongs to Special Issue Conference Material Science and Nanotechnology
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References
1. Werner A. Coordination Compounds. Department of Chemistry, University of Siena, Via Aldo Moro 2, I-53100 Siena, Italy; 2010.
2. Qin W, Long S, Panunzio M, Biondi S. Schiff bases: a short survey on an evergreen chemistry tool. Molecules. 2013; 18 (10): 12264–12289.
3. Kostova I, Saso L. Advances in research of Schiff-base metal complexes as potent antioxidants. Curr Med Chem. 2013; 20 (36): 4609–4632.
4. Arunadevi A, Raman N. Biological response of Schiff base metal complexes incorporating amino acids – a short review. J Coord Chem. 2020; 73 (15): 2095–2116.
5. Patil SA, Naik VH, Kulkarni AD, Badami PS. Spectroscopic, DNA cleavage and antimicrobial studies of Co (II), Ni (II) and Cu (II) complexes of sulfur donor Schiff bases. J Sulfur Chem. 2010; 31 (2): 109–121.
6. Prachayasittikul V, Prachayasittikul S, Ruchirawat S, Prachayasittikul V. 8-Hydroxyquinolines: a review of their metal chelating properties and medicinal applications. Drug Des Dev Ther. 2013; 7: 1157–1178.
7. Bencini A, Lippolis V. 1,10-Phenanthroline: a versatile building block for the construction of ligands for various purposes. Coord Chem Rev. 2010; 254 (17–18): 2096–2180.
8. Monzon LM. Electrochemical characterisation of bis(1,10-phenanthroline) gadolinium (III) trichloride formed in situ. J Electroanal Chem. 2010; 648 (1): 47–53.
9. Coyle B, Kavanagh K, McCann M, Devereux M, Geraghty M. Mode of anti-fungal activity of 1,10-phenanthroline and its Cu (II), Mn (II) and Ag (I) complexes. Biometals. 2003; 16 (2): 321–329.
10. Qizhuang H, Jing Y, Hui M, Hexing L. Studies on the spectra and antibacterial properties of rare earth dinuclear complexes with L-phenylalanine and o-phenanthroline. Mater Lett. 2006; 60 (3): 317-320.
11. Hodnett EM. Schiff bases of salicylaldehyde and their cobalt (II) derivatives as antitumor agents. Proc Oklahoma Acad Sci. 1966; 46: 107–111.
12. Vincent JB. Recent developments in the biochemistry of chromium (III). Biol Trace Elem Res. 2004; 99 (1): 1–16.
13. Farrell N. Transition Metal Complexes as Drugs and Chemotherapeutic Agents (Vol. 11). New York: Springer Science and Business Media; 2012.
14. Tamiru G, Abebe A, Abebe M, Liyew M. Synthesis, structural investigation and biological application of new mono-and binuclear cobalt (II) mixed-ligand complexes containing 1,10-phenanthroline, acetamide and ethylenediamine. Ethiopian J Sci Technol. 2019; 12 (1): 69–91.
15. Morrison RT, Boyd RN. Organic Chemistry. 6th edition. London, UK: Prentice Hall International; 1992.
16. Yadav LDS. Organic Spectroscopy. New York: Springer Science and Business Media; 2013.
17. Popov LD, Levchenkov SI, Shcherbakov IN, Aleksandrov GG, Raspopova EA, Tupolova YP, Lukov VV. Tetranuclear copper (II) complex with the µ4-1,6-hexadicarboxylate linker: crystal structure and magnetic properties. Russ J Coord Chem. 2017; 43 (9): 559–564.
18. Popov LD, Tupolova YP, Levchenkov SI, Tsaturyan AA, Lukov VV, Borodkin SA, Shcherbakov IN, Burlov AS, Zubenko AA, Pankov IV. Physico-chemical study of the complex formation between 2-(tosylamino) benzaldehydebishydrazones and transition metal ions. Russ J Gen Chem. 2015; 85 (8): 1902-1909.
19. Sliverstein RM, Bassler G, Morill TC. Spectrometric Identification of Organic Compounds. 4th edition. New York: Wiley; 1981.
20. Kalsi PS. Spectroscopy of Organic Compounds. New Delhi, India: New Age International; 2007.
21. Kırgız MS, de Sousa Galdino AG, Kinuthia J, Khitab A, Ul Hassan MI, Khatib J, El Naggar H, Thomas C, Mirza J, Kenai S, Nguyen YA, Nehdi M, Syarif M, Asteyat A, Gobinath R, Soliman A, Tagbor TA, Kumbhalkar MA, Bheel N, Tiwary C. Synthesis, physico-mechanical properties, material processing, and math models of novel superior materials doped flake of carbon and colloid flake of carbon. J Mater Res Technol. 2021; 15 (November–December): 4993–5009. doi: 10.1016/j.jmrt.2021.10.089
Journal of Polymer and Composites
| Volume | 11 |
| Special Issue | 02 |
| Received | December 8, 2022 |
| Accepted | January 31, 2023 |
| Published | January 1, 2023 |