Preparing Chitosan Hybrid Nanocomposites by Novel Additives for Wound Healing

Year : 2023 | Volume : 11 | Issue : 02 | Page : 9-23

    Ishraq Abboodi Fadhil

  1. Lecturer, University of Al-Qadisiyah/College of The Education, , Iraq


Biomaterials made from chitosan have been discovered to be particularly unique marine polysaccharides (or polycarbohydrates) with a wide range of physico-chemical and biological characteristics suitable for biomedicine field. Due to net positive charge of chitosan, it is essentially capable of chemically binding with negatively charged surfaces A biodegradable blend of chitosan nanoparticles (CHT), poly vinyl alcohol (PVA) and polyethylene glycol (PEG) hybridized with metal
oxides nanopowders were prepared and used for wound healing application. The exploited oxides were titanium dioxide (TiO2), zinc oxide (ZnO), and magnesium oxide (MgO). Scanning electron microscopy (SEM), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), and in vivo study by applying the final gels on the injured skins were used to characterize the morphology, thermal, and biological properties of hybrids. The in vivo animal tests were employed to confirm the biocompatibility of the nanocomposites as wound healers. The hybrid’s ability for wound healing has been improved by combining PVA, PEG, and CHT along with the proper concentrations of TiO2, ZnO, and MgO. The aim of this work was to create an attractive product for wound healing could be used for human health care. Consequently, dual/triple-hybrid systems have been adopted by integrating TiO2/MgO, TiO2/ZnO, MgO/ZnO, and TiO2/MgO/ZnO nanocomposites. Eventually, the wound contraction was accelerated by treating the injured skin with a ternary-hybrid system within a period of less than a week with no toxicity up to concentration of 100 μg/mL on WRL-68 cell line. All the parameters observed (presence of necrotic tissue, clotting and crust, re-epithelialization and granulation tissue growth) were affected; suggesting that chitosan and the metals oxides nanoparticles have a substantial efficiency in tissue regeneration. This is an indication to collagen maturation progress. Based on the results, the previously mentioned hybrid will be a promising
nontoxic biomaterial for wound treatment application. The in vivo model revealed that the novel composite of CHT/PVA/PEG blend hybridized with the three different types of the suggested metals oxides have superior curing effect as compared to Fucidin ointment.

Keywords: Chitosan blend, hybrid, nanocomposites, wound healing, biocompatibility, biodegradability

This article belongs to Special Issue Conference Material Science and Nanotechnology

How to cite this article: Ishraq Abboodi Fadhil Preparing Chitosan Hybrid Nanocomposites by Novel Additives for Wound Healing jopc 2023; 11:9-23
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Conference Open Access Original Research
Volume 11
Issue 02
Received December 8, 2022
Accepted January 31, 2023
Published June 19, 2023