Exploring the properties and extraction of neem leaves

Year : 2024 | Volume :01 | Issue : 02 | Page : 32-39
By

Shrinkhala Rai

  1. Student, Department of Biotechnology, College-Goel institute of Technology and Management, Lucknow, Uttar Pradesh, India

Abstract

Neem (Azadirachta indica) is a versatile medicinal plant, for its diverse therapeutic properties. This abstract provides a comprehensive overview of recent research focusing on phytochemical analysis, biochemical characterization, and antimicrobial susceptibility testing of Neem extracts. Utilizing the different from of chemical used in it, phytochemical analysis identified a plethora of secondary metabolites within Neem, including alkaloids, flavonoids, terpenoids, steroids, saponin, tannins, quinone, and phenolic compounds, indicative of its complex chemical composition. These bioactive constituents contribute significantly to Neem’s pharmacological effects, highlighting its potential as a valuable natural remedy in healthcare.
Biochemical analysis further elucidated Neem’s enzymatic activities, particularly its antioxidant potential. Various enzymes involved in antioxidant pathways were identified, emphasizing Neem’s ability to combat oxidative stress-related disorders and promote overall health and well-being through its antioxidant properties.
Antimicrobial susceptibility testing demonstrated the potent efficacy of Neem extracts against a broad spectrum of pathogens, including bacteria, fungi, and parasites. Neem’s antimicrobial activity can be attributed to its diverse bioactive constituents, which exhibit inhibitory effects on microbial growth and proliferation. These findings underscore Neem’s potential as a natural alternative for antimicrobial therapy, offering promising avenues for the treatment and prevention of infectious diseases.
In conclusion, this abstract underscore the importance of Neem in modern pharmacology, highlighting its phytochemical diversity, biochemical attributes, and potent antimicrobial properties. The results emphasize the need for further research and exploration of Neem’s therapeutic potential in healthcare and pharmaceutical industries, paving the way for the development of novel Neem-based therapeutics.

Keywords: Neem, Azadirachta indica, phytochemical analysis, biochemical characterization, antimicrobial susceptibility testing, medicinal plant, natural remedies, therapeutic potential, pharmacology.

[This article belongs to International Journal of Toxins and Toxics(ijtt)]

How to cite this article: Shrinkhala Rai. Exploring the properties and extraction of neem leaves. International Journal of Toxins and Toxics. 2024; 01(02):32-39.
How to cite this URL: Shrinkhala Rai. Exploring the properties and extraction of neem leaves. International Journal of Toxins and Toxics. 2024; 01(02):32-39. Available from: https://journals.stmjournals.com/ijtt/article=2024/view=134055

Browse Figures

References

  1. Arumugam, A., Agullo, P., Boopalan, T., Nandy, S., Lopez, R., Gutierrez, C., … Rajkumar, L. (2014). Neem leaf extract inhibits mammary carcinogenesis by altering cell proliferation, apoptosis, and angiogenesis. Cancer Biology and Therapy, 15(1), 26–34. https://doi.org/10.4161/cbt.26604
  2. Sitasiwi, A. J., Isdadiyanto, S., & Mardiati, S. M. (2018). Effect of ethanolic Neem (Azadirachta indica) leaf extract as an herb contraceptive on Hepato-somatic Index of the male mice (Mus musculus). Journal of Physics: Conference Series, 1025, Conference 1. https://doi.org/10.1088/1742-6596/1025/1/012043.
  3. Auta, T., & Hassan, A. T. (2016). Reproductive toxicity of aqueous wood-ash extract of Azadirachta indica (neem) on male albino mice. Asian Pacific Journal.
  4. Benisheikh AA, Muhammad FM, Kelluri H, Aliyu ZM, Mallam UB, Jibrin MW. Phytochemical extraction and antimicrobial studies on crude leaf extract of Azadirachta indica (Neem) in semi-arid region of Borno State, Nigeria. International Journal of Research and Review. 2019;6(12):516-22.
  5. Siddiqui AA, Ali M (1997). Practical pharmaceutical chemistry. 1st ed.; CBS publishers and Distributors, New Delhi, PP. 126-31.
  6. Omóbòwálé, T. O., Oyagbemi, A. A., Adejumobi, O. A., Orherhe, E. V., Amid, A. S., Adedapo, A. A., … Yakubu, M. A. (2016). Preconditioning with Azadirachta indica ameliorates cardiorenal dysfunction through reduction in oxidative stress and extracellular signal regulated protein kinase signalling. Journal of Ayurveda and Integrative Medicine, 7(4), 209–217. https://doi.org/10.1016/j.jaim.2016.08.006.
  7. Bauer AW, Kirby WM, Sherris JC, Turck M. Antibiotic susceptibility testing by a standardized single disk method. American journal of clinical pathology. 1966 Apr 1;45(4_ts):493-6.
  8. Harborne JB. Textbook of Phytochemical Methods. A Guide to Modern Techniques of Plant Analysis (5th ed.). London: Chapman and Hall Ltd. 1998.
  9. Kumar S, Vandana UK, Agrwal D, Hansa J. Analgesic, Anti-inflammatory and Anti-pyretic Effects of Azadirachta indica(Neem) Leaf Extract in albino rats. International Journal Scientific Research. 2015;4: 713–721.
  10. Alzohairy, M. A. (2016). Therapeutics role of Azadirachta indica (Neem) and their active constituents in diseases prevention and treatment. Evidence-based Complementary and Alternative Medicine, 2016, 7382506. https://doi.org/10.1155/2016/7382506
  11. Wayne PA. Clinical and Laboratory Standards Institute (CLSI); 2010. Performance standards for antimicrobial susceptibility testing. 2010;20:1-5.
Regular Issue Subscription Original Research
Volume 01
Issue 02
Received February 18, 2024
Accepted February 22, 2024
Published March 2, 2024
Views: 81