Tropical Medicine and Leishmaniasis: Unraveling the Complexities of a Neglected Tropical Disease

Year : 2024 | Volume :01 | Issue : 02 | Page : 29-39
By

Shruti Morankar

Abstract

Protozoan parasites of the genus Leishmania are the cause of the vector-borne disease leishmaniasis, which poses a serious threat to global public health in tropical and subtropical areas. Despite being common and having a significant effect on human health, leishmaniasis is still a neglected tropical disease, with little funding available for investigation and prevention. This article examines the relationship between leishmaniasis and tropical medicine, emphasizing the particular difficulties this intricate illness presents and the continuous efforts to treat it. With its emphasis on illnesses common in tropical areas, tropical medicine offers an essential foundation for comprehending the pathophysiology, epidemiology, and treatment of leishmaniasis. Even with these developments, leishmaniasis detection and treatment still face difficulties, especially in areas with low resources where the illness is most prevalent. Disease control is still hampered by a lack of access to reliable diagnostic instruments and efficient therapies, which emphasizes the necessity of ongoing funding for research and development. In conclusion, there is a rare chance to address the intricacies of this neglected tropical illness thanks to the convergence of research on leishmaniasis and tropical medicine. Through the utilization of interdisciplinary techniques and cooperative endeavours, we can progress our comprehension of leishmaniasis and formulate inventive approaches for managing and eradicating the disease, consequently enhancing the welfare and health of impacted communities.

Keywords: Protozoan , leishmania, tropical medicine, epidemiology, neglected tropical illness, vector-borne diseases

[This article belongs to International Journal of Tropical Medicines(ijtm)]

How to cite this article: Shruti Morankar. Tropical Medicine and Leishmaniasis: Unraveling the Complexities of a Neglected Tropical Disease. International Journal of Tropical Medicines. 2024; 01(02):29-39.
How to cite this URL: Shruti Morankar. Tropical Medicine and Leishmaniasis: Unraveling the Complexities of a Neglected Tropical Disease. International Journal of Tropical Medicines. 2024; 01(02):29-39. Available from: https://journals.stmjournals.com/ijtm/article=2024/view=145135


References

  1. Desjeux, P., 2004. Leishmaniasis: current situation and new perspectives. Comparative immunology, microbiology and infectious diseases, 27(5), pp.305-318.
  2. Murray, H.W., Berman, J.D., Davies, C.R. and Saravia, N.G., 2005. Advances in leishmaniasis. The Lancet, 366(9496), pp.1561-1577.
  3. Reithinger, R., Dujardin, J.C., Louzir, H., Pirmez, C., Alexander, B. and Brooker, S., 2007. Cutaneous leishmaniasis. The Lancet infectious diseases, 7(9), pp.581-596.
  4. Torres-Guerrero, E., Quintanilla-Cedillo, M.R., Ruiz-Esmenjaud, J. and Arenas, R., 2017. Leishmaniasis: a review. F1000Research, 6.
  5. Steverding, D., 2017. The history of leishmaniasis. Parasites & vectors, 10, pp.1-10.
  6. Sharma, U. and Singh, S., 2009. Immunobiology of leishmaniasis.
  7. Liew, F.Y. and O’donnell, C.A., 1993. Immunology of leishmaniasis. Advances in parasitology, 32, pp.161-259.
  8. Alvar, J., Vélez, I.D., Bern, C., Herrero, M., Desjeux, P., Cano, J., Jannin, J., Boer, M.D. and WHO Leishmaniasis Control Team, 2012. Leishmaniasis worldwide and global estimates of its incidence. PloS one, 7(5), p.e35671.
  9. Pradhan, S., Schwartz, R.A., Patil, A., Grabbe, S. and Goldust, M., 2022. Treatment options for leishmaniasis. Clinical and experimental dermatology, 47(3), pp.516-521.
  10. Pirmez, C., Yamamura, M., Uyemura, K., Paes-Oliveira, M., Conceicao-Silva, F. and Modlin, R., 1993. Cytokine patterns in the pathogenesis of human leishmaniasis. The Journal of clinical investigation, 91(4), pp.1390-1395.
  11. Lysenko, A.J., 1971. Distribution of leishmaniasis in the Old World. Bulletin of the World Health Organization, 44(4), p.515.
  12. Pearson, R.D., Wheeler, D.A., Harrison, L.H. and Kay, H.D., 1983. The immunobiology of leishmaniasis. Reviews of infectious diseases, 5(5), pp.907-927.
  13. Maia, C., Rolão, N., Nunes, M., Gonçalves, L. and Campino, L., 2007. Infectivity of five different types of macrophages by Leishmania infantum. Acta tropica, 103(2), pp.150-155.
  14. Oryan, A. and Akbari, M., 2016. Worldwide risk factors in leishmaniasis. Asian Pacific journal of tropical medicine, 9(10), pp.925-932.
  15. Davies, C.R., Llanos-Cuentas, E.A., Sharp, S.J., Canales, J., Leon, E., Alvarez, E., Roncal, N. and Dye, C., 1997. Cutaneous leishmaniasis in the Peruvian Andes: factors associated with variability in clinical symptoms, response to treatment, and parasite isolation rate. Clinical infectious diseases, 25(2), pp.302-310.
  16. Ghazanfar, M. and Malik, M.F., 2016. Sandfly and leishmaniasis: a review. Journal of Ecosystem & Ecography, 6(3), p.434.
  17. Mann, S., Frasca, K., Scherrer, S., Henao-Martínez, A.F., Newman, S., Ramanan, P. and Suarez, J.A., 2021. A review of leishmaniasis: current knowledge and future directions. Current tropical medicine reports, 8, pp.121-132.
  18. Sakkas, H., Gartzonika, C. and Levidiotou, S., 2016. Laboratory diagnosis of human visceral leishmaniasis. Journal of vector borne diseases, 53(1), pp.8-16.
  19. Savoia, D., 2015. Recent updates and perspectives on leishmaniasis. The Journal of Infection in Developing Countries, 9(06), pp.588-596.
  20. Alvar, J., Canavate, C., Molina, R., Moreno, J. and Nieto, J., 2004. Canine leishmaniasis. Advances in parasitology, 57(3), pp.1-88.
  21. Brandão-Filho, S.P., Campbell-Lendrum, D., Brito, M.E., Shaw, J.J. and Davies, C.R., 1999. Epidemiological surveys confirm an increasing burden of cutaneous leishmaniasis in north-east Brazil. Transactions of the Royal Society of Tropical Medicine and Hygiene, 93(5), pp.488-494.
  22. Wilson, M.E. and Streit, J.A., 1996. Visceral leishmaniasis. Gastroenterology Clinics, 25(3), pp.535-551.
  23. Eshetu, E. and Bassa, A.A.T., 2016. The Public Health significance of Leishmaniasis: an overview. Journal of Natural Sciences Research, 6(5), pp.48-57.
  24. Pastorino, A.C., Jacob, C.M., Oselka, G.W. and Carneiro-Sampaio, M.M., 2002. Visceral leishmaniasis: clinical and laboratorial aspects. J Pediatr (Rio J), 78(2), pp.120-7.
  25. Oryan, A. and Akbari, M., 2016. Worldwide risk factors in leishmaniasis. Asian Pacific journal of tropical medicine, 9(10), pp.925-932.
  26. Desjeux, P., 2001. The increase in risk factors for leishmaniasis worldwide. Transactions of the royal society of tropical medicine and hygiene, 95(3), pp.239-243.
  27. World Health Organization, 2002. Urbanization: an increasing risk factor for leishmaniasis. Weekly Epidemiological Record= Relevé épidémiologique hebdomadaire, 77(44), pp.365-370.
  28. Valero, N.N.H. and Uriarte, M., 2020. Environmental and socioeconomic risk factors associated with visceral and cutaneous leishmaniasis: a systematic review. Parasitology research, 119(2), pp.365-384.
  29. Cortes, S., Vaz, Y., Neves, R., Maia, C., Cardoso, L. and Campino, L., 2012. Risk factors for canine leishmaniasis in an endemic Mediterranean region. Veterinary parasitology, 189(2-4), pp.189-196.
  30. Bashaye, S., Nombela, N., Argaw, D., Mulugeta, A., Herrero, M., Nieto, J., Chicharro, C., Cañavate, C., Aparicio, P., Vélez, I.D. and Alvar, J., 2009. Risk factors for visceral leishmaniasis in a new epidemic site in Amhara Region, Ethiopia. American Journal of Tropical Medicine and Hygiene, 81(1), p.34.
Regular Issue Subscription Review Article
Volume 01
Issue 02
Received April 8, 2024
Accepted April 18, 2024
Published May 4, 2024
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